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Insulin Lispro + Insulin Lispro Protamine

Information about Insulin Lispro + Insulin Lispro Protamine

Insulin Lispro + Insulin Lispro Protamine Uses

Insulin Lispro+Insulin Lispro Protamine is used in the treatment of diabetes mellitus (Type 1 & Type 2). It is indicated in patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis.

How Insulin Lispro + Insulin Lispro Protamine works

Insulin Lispro + Insulin Lispro Protamine is a combination of two insulin preparations: Insulin lispro and insulin lispro protamine. Insulin lispro has a fast onset of action while insulin lispro protamine has a prolonged duration of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells, and suppressing the production of sugar in the liver.

Common side effects of Insulin Lispro + Insulin Lispro Protamine

Hypoglycemia (low blood glucose level), Injection site allergic reaction, Lipodystrophy (skin thickening or pits at the injection site), Itching, Rash
Written By
Reviewed By
MD (Pharmacology), MBBS
Last updated:
18 Feb 2020 | 11:54 AM (UTC)
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Available Medicine for Insulin Lispro + Insulin Lispro Protamine

Humalog MixEli Lilly and Company India Pvt Ltd
745 to ₹9364 variant(s)
Eglucent MixLupin Ltd
745 to ₹9364 variant(s)

Expert advice for Insulin Lispro + Insulin Lispro Protamine

  • Take it 15 minutes before a meal or within 20 minutes after starting a meal.
  • Injection below the skin of the abdomen results in faster absorption as compared to other injection sites such as skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
  • Injection sites must be rotated to prevent hard lumps from developing at one site. 
  • Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Do not share your insulin device with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Opened vials / cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).

Frequently asked questions for Insulin Lispro + Insulin Lispro Protamine

Insulin Lispro + Insulin Lispro Protamine

Q. How do I inject the dose of my insulin?

Wash your hands before injecting. Choose a site for injection. Clean the skin as instructed. Remove outer needle cap. Stabilize the skin by spreading it or pinching up a large area. Insert the needle as instructed. Press the knob. Pull the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area. Using the outer needle cap, unscrew the needle and dispose of it safely. Use of injection sites should be rotated so that the same site is not used more than approximately once a month.

Q. How to prepare my Insulin Lispro+Insulin Lispro Protamine device before taking the injection?

The insulin device should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. If not, repeat the above procedure until contents are mixed. Do not shake vigorously as this may cause frothing which may interfere with the correct measurement of the dose. The device/cartridge should be examined frequently and not be used if clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving a frosted appearance.

Q. Must I prime my pen before using it?

Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. For priming, turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and "0" is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.

Q. What should I do if the dose knob of the pen is hard to push?

Pushing the dose knob of the pen more slowly will make it easier to inject. Your needle may be blocked. Put on a new needle and prime the pen.

Q. What are the potential side effects of Insulin Lispro+Insulin Lispro Protamine?

Low blood sugar (hypoglycemia) is the most common side effect. This may be associated with listlessness, confusion, palpitations, headache, sweating, and vomiting. Always carry a quick source of sugar such as glucose tablets, hard candy or juice to treat low blood sugar. Use of insulin is contraindicated during the episodes of hypoglycemia. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site.

Q. What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor.

Q. Which drugs can increase the insulin requirement of a patient?

Insulin requirements may be increased by medications with hyperglycemic activity (medicines that increase glucose levels) such as corticosteroids, isoniazid, certain lipid-lowering drugs (e.g., niacin), estrogens, oral contraceptives, phenothiazines, and thyroid replacement therapy.

Q. Which drugs can decrease the insulin requirement of a patient?

Insulin requirements may be decreased in the presence of drugs that increase insulin sensitivity or have hypoglycemic (glucose lowering) activity, such as oral antidiabetic agents, salicylates, sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), angiotensin-converting-enzyme inhibitors, angiotensin II receptor blocking agents, beta-adrenergic blockers, inhibitors of pancreatic function (e.g., octreotide), and alcohol. Beta-adrenergic blockers may mask the symptoms of hypoglycemia in some patients.

Q. Is it safe to use Insulin Lispro+Insulin Lispro Protamine during pregnancy and lactation (breastfeeding)?

Data on a large number of exposed pregnancies do not indicate any adverse effect of insulin lispro (main constituent of Insulin Lispro+Insulin Lispro Protamine) on pregnancy or on the health of the fetus/newborn. Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Patients with diabetes should inform their doctor, if they are pregnant or are contemplating the pregnancy. Careful monitoring of glucose control, as well as general health, is essential in pregnant patients with diabetes. Patients with diabetes who are breastfeeding may require adjustments in insulin dose, diet or both.


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