Crizanlizumab is used in the treatment of sickle cell anemia, multiple sclerosis (MS) and psoriasis.

Crizanlizumab works by binding to a protein (P-selectin) that causes the blood cells to stick together. Blocking this protein prevents blood cells from sticking with each other and to the walls of blood vessels. This improves blood supply throughout the body. This also lowers the risk of pain crisis and other severe complications of sickle cell disease, such as stroke and organ damage.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them