Ceftriaxone + Sulbactam

Written By Dr. Sakshi Jain

Reviewed By Dr. Rajeev Sharma

Last updated 25 Nov 2025 | 09:37 AM (UTC)

Ceftriaxone + Sulbactam Uses

Ceftriaxone+Sulbactam is used in the treatment of bacterial infections.

Available generics for Ceftriaxone + Sulbactam

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Biocef-S 375 Injection

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How Ceftriaxone + Sulbactam works

Ceftriaxone + Sulbactam is a combination of two medicines: Ceftriaxone and Sulbactam. Ceftriaxone is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Ceftriaxone against bacteria.

Common side effects of Ceftriaxone + Sulbactam

Increased white blood cell count (eosinophils), Decreased white blood cell count (lymphocytes), Low blood platelets, Rash, Diarrhea, Increased liver enzymes, Injection site reactions (pain, swelling, redness)

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Medicine brands for Ceftriaxone + Sulbactam

Monocef-SB

Aristo Pharmaceuticals Pvt Ltd

₹79 to ₹213

3 variant(s)

Traxol S

Cachet Pharmaceuticals Pvt Ltd

₹36 to ₹215

4 variant(s)

Oframax Forte

Sun Pharmaceutical Industries Ltd

₹187 to ₹187

1 variant(s)

Milibact

Glenmark Pharmaceuticals Ltd

₹55 to ₹199

3 variant(s)

Odicef S

Galpha Laboratories Ltd

₹22 to ₹120

4 variant(s)

Powercef XP

Dr Reddy's Laboratories Ltd

₹98 to ₹98

1 variant(s)

Xone SB

Alkem Laboratories Ltd

₹41 to ₹225

3 variant(s)

Monotax SB

Zydus Healthcare Limited

₹184 to ₹184

1 variant(s)

Powercef S

Dr Reddy's Laboratories Ltd

₹172 to ₹172

1 variant(s)

Xtum

Shreya Life Sciences Pvt Ltd

₹47 to ₹352

6 variant(s)

Expert advice for Ceftriaxone + Sulbactam

You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect. Taking probiotics along with Ceftriaxone + Sulbactam may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Take it with food and plenty of fluids to avoid an upset stomach.
Stop taking Ceftriaxone + Sulbactam and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Frequently asked questions for Ceftriaxone + Sulbactam

Q. Can the use of Ceftriaxone+Sulbactam cause allergic reaction?

Yes, Ceftriaxone+Sulbactam can cause an allergic reaction and is considered to be harmful for patients with known allergy to a group of antibiotic called cephalosporins. Seek emergency medical help if you have any sign of an allergic reaction like hives; difficulty in breathing; swelling of your face, lips, tongue, or throat.

Q. Can the use of Ceftriaxone+Sulbactam cause diarrhea?

Yes, the use of Ceftriaxone+Sulbactam can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.

Q. How long does Ceftriaxone+Sulbactam takes to work?

Usually, Ceftriaxone+Sulbactam starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

Q. What if I don't get better after using Ceftriaxone+Sulbactam?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

Q. Can I stop taking Ceftriaxone+Sulbactam when I feel better?

No, do not stop taking Ceftriaxone+Sulbactam and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.