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Kidney ablation, nerve block, poisoning of ethylene glycol and methanol, premature labour.

How it works

Alcohol stimulates GABA at GABA-A receptors and inhibits the opening of NMDA receptor/channels by preventing glutamate. As an antidote, it inhibits the rapid metabolism of methanol to toxic intermediates eg, formaldehyde and formic acid due to its greater affinity to alcohol dehydrogenase. Thus, the toxicity of methanol is delayed or to an extent hindered.

Common side effects

Drowsiness, Acute gastritis, Balance disorder (loss of balance), Central pontine myelinolysis, Central nervous system depression, Degeneration of mammilary bodies, Disinhibition, Distorted speech and loss of muscle control, Fetal alcohol syndrome, Liver toxicity, Korsakoff(s) psychosis, Wernicke(s) disaese


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Content on this page was last updated on 17 May, 2016, by Dr. Varun Gupta (MD Pharmacology)