Aceclofenac + Paracetamol + Tizanidine is a combination of three medicines: Paracetamol, Aceclofenac, and Tizanidine. Paracetamol is an antipyretic (fever reducer) and Aceclofenac is a non-steroidal antiinflammatory drug (NSAID). They work by blocking the release of certain chemical messengers in the brain that cause fever and pain respectively. Tizanidine is a muscle relaxant. It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and to improve pain and movement of muscles.