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Scl-70 Antibody

Scl-70 Antibody near me in Navi Mumbai

Also referred as
Scleroderma Antibody (Scl-70)
For men & women
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The Scl-70 Antibody test detects antibodies against topoisomerase I (SCL-70) in the blood. This test supports evaluation and differentiation of systemic sclerosis (scleroderma) from other connective tissue disorders. This test is widely available at an affordable price with Tata 1mg labs in Navi Mumbai.

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Understanding Scl-70 Antibody

SCL-70, also known as DNA topoisomerase I, is an enzyme found in the cell nucleus that helps unwind DNA during replication and transcription. In certain autoimmune conditions, the immune system mistakenly produces antibodies against this enzyme. The presence of SCL-70 antibodies in the blood suggests abnormal immune activity and is considered a significant marker for systemic sclerosis (scleroderma).

SCL-70 antibodies are strongly associated with diffuse cutaneous systemic sclerosis, a severe form of scleroderma that can affect the skin, lungs, kidneys, and other internal organs. However, these antibodies are not exclusive and may appear in overlap syndromes. 

This test supports the diagnosis when combined with clinical findings and other tests and assesses the risk of complications, especially interstitial lung disease. These antibodies may also appear in other autoimmune diseases like lupus or mixed connective tissue disease (MCTD), but with lower specificity.

Doctors may recommend the Scl-70 Antibody test if there are symptoms such as thickened or hardened skin, joint stiffness, Raynaud’s phenomenon, shortness of breath, or unexplained fatigue, which may suggest systemic sclerosis. Often performed alongside other antibody panels (such as ANA or ENA profiles), this test plays an important role in early detection, accurate disease classification, and guiding long-term treatment. By identifying these antibodies, doctors can monitor disease progression, anticipate potential organ involvement, and plan appropriate therapies.

Usually, no special preparation is required for this test. Eat and drink as per the daily routine. However, sharing the clinical history, current medications, and supplement use with the doctor before giving the sample is preferred, as these may influence the results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly. 

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does Scl-70 Antibody measure?

The Scl-70 Antibody test detects anti-topoisomerase I antibodies in the blood. These autoantibodies target topoisomerase I, an enzyme essential for unwinding DNA during cell replication. Their presence indicates an autoimmune reaction, where the immune system mistakenly attacks the body’s own tissues.

SCL-70 antibodies are found in about 40% of patients with progressive systemic sclerosis (PSS). A positive result suggests a higher likelihood of systemic sclerosis, particularly the diffuse cutaneous type, which is more often associated with lung and internal organ involvement. However, not all patients with systemic sclerosis test positive for SCL-70 antibodies, and in some cases, these antibodies may also appear in other connective tissue diseases. A negative result does not rule out systemic sclerosis but makes the diagnosis less likely. Results must always be interpreted in combination with symptoms, physical findings, and other laboratory and imaging studies, not standalone. 

FAQs related to Scl-70 Antibody in Navi Mumbai

The Scl-70 Antibody test is a blood test that supports systemic sclerosis evaluation by finding out antibodies against topoisomerase I, a nuclear enzyme and risk assessment, and disease monitoring.
Your doctor may order this test if you have symptoms such as skin thickening, joint stiffness, Raynaud’s phenomenon, difficulty breathing, or fatigue, which may suggest systemic sclerosis or another autoimmune connective tissue disease.
No, fasting is not required for the Scl-70 Antibody test.
Yes. The Scl-70 Antibody test is often ordered with ANA (antinuclear antibody) and ENA (extractable nuclear antigen) panels to provide a clearer picture of autoimmune activity and to differentiate between overlapping connective tissue disorders.
Rarely, these antibodies may also appear in other autoimmune connective tissue disorders, but they are most specific for systemic sclerosis.
Yes. In Navi Mumbai, you can schedule the Scl-70 Antibody test near you with Tata 1mg Labs. The test is easy to book, cost-effective, and available with a comprehensive report.
Yes, home sample collection for the Scl-70 Antibody test is readily available in Navi Mumbai. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.
If you want to schedule the Scl-70 Antibody test with Tata 1mg Labs in Navi Mumbai, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want to the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.
Tata 1mg Labs is a pocket-friendly platform for booking lab tests in Navi Mumbai. The Scl-70 Antibody test is available at an affordable price of Rs. 1579.
At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 120 hours to provide the reports of the Scl-70 Antibody test in Navi Mumbai.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Swati Gupta (Anand)
MD Lab Medicine, MBBS
Want to know moreRead our editorial policy
Last Updated5th Oct 2026

Scl-70 Antibody test price for other cities

Price inNew DelhiRs. 1680
Price inMumbaiRs. 1579
Price inBangaloreRs. 1589
Price inGurgaonRs. 1379
Price inRanchiRs. 1209

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Scl-70 Antibody