MGMT (06 - Methyl Guanine Methyl Transferase) gene promoter methylation detection assay near me in New Delhi

The MGMT (06 - Methyl Guanine Methyl Transferase) gene promoter methylation detection assay test is a test that checks if a part of the MGMT gene called the promoter is methylated (chemically changed) or not. The MGMT gene helps repair damaged DNA in cells. When its promoter is methylated, the gene may not work properly. This can affect how the body responds to certain cancer treatments, especially in brain tumors like glioblastoma. For this test, DNA is extracted from a tumor tissue sample (FFPE block) and treated with a special chemical called bisulfite, which helps identify methylation. The DNA is then tested using real-time PCR (qMSP) to detect whether the MGMT promoter is methylated. If a methylation signal is detected, the result is reported as methylated (positive). If no methylation signal is found, the result is unmethylated (negative). In additiona, a reference gene (ACTB) is also tested to confirm the quality of the sample and accuracy of the result. The results of this test provide important information about genetic changes in the tumor, which can help guide further medical evaluation and treatment planning.

Note: One representative block of the tumor is required. However, 1-4 representative blocks of tumors are acceptable.

Disclaimer: In no event shall the liability of TATA 1MG exceed the amount of actual cost of test charges incurred by the customer as stated on the invoice issued by Tata 1mg.