BCR-ABL1 Quantitative International Scale [IS] near me in Ghaziabad

The BCR-ABL1 Quantitative International Scale [IS] test is a molecular diagnostic test that detects and measures the level of BCR-ABL1 fusion gene transcripts in blood samples using Polymerase Chain Reaction (PCR) technology.

This fusion gene forms when parts of the BCR (Breakpoint Cluster Region) gene from chromosome 22 and the ABL (Abelson) gene from chromosome 9 join together. The resulting Philadelphia chromosome is commonly found in patients with Chronic Myeloid Leukemia (CML) and some cases of Acute Lymphoblastic Leukemia (ALL).

The IS (International Scale) provides a standardized way to report BCR-ABL1 transcript levels, ensuring consistency across laboratories. The results are given as a percentage: lower IS values reflect a better treatment response. For example, a major molecular response (MMR) is achieved when the IS score is 0.1% or below, indicating strong disease control.

Doctors use this test to diagnose, monitor treatment progress, and detect relapse in individuals with CML. Regular monitoring helps assess the effectiveness of targeted therapies such as tyrosine kinase inhibitors (TKIs) and guides necessary treatment adjustments for optimal outcomes.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted along with the bone marrow sample.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.