Autoimmune Gastritis & Celiac Disease Panel, IgG by LIA near me in Tiruvallur

Autoimmune gastritis and celiac disease are immune-mediated disorders in which the body produces antibodies that attack its own gastrointestinal tissues. Autoimmune gastritis primarily affects the stomach lining, leading to destruction of parietal cells, which impairs the production of gastric acid and intrinsic factor (essential for Vitamin B12 absorption). Celiac disease shows an immune response to gluten that damages the small intestine. These conditions may coexist and often present with overlapping symptoms such as chronic abdominal discomfort, anemia, fatigue, and nutritional deficiencies.

The Autoimmune Gastritis & Celiac Disease Panel, IgG by LIA measures a panel of immunoglobulin G (IgG) antibodies that provide a comprehensive assessment of immune activity related to these disorders. Gluten in wheat is broken down into gliadin, which is modified by tissue transglutaminase (tTG) enzyme to deamidated gliadin; in susceptible individuals, antibodies to these cause inflammation and damage to the small intestine lining.

Tissue transglutaminase IgG (tTG IgG) and deamidated gliadin peptide IgG (DGP IgG) are used to evaluate celiac disease, particularly in individuals with IgA deficiency or when IgA-based testing is inconclusive. Anti-Saccharomyces cerevisiae IgG (ASCA IgG) reflects abnormal immune responses within the gastrointestinal tract. They are immune antibodies directed against components (mannan/mannophosphopeptide) of baker’s yeast and are commonly found in patients with Crohn's disease. Parietal cell antibody IgG was first identified in patients with pernicious anemia (Addison’s anemia), related to impaired vitamin B12 absorption. These antibodies may also be found in other autoimmune conditions such as Hashimoto's thyroiditis, Type 1 diabetes mellitus, and chronic atrophic gastritis type A. Intrinsic Factor (IF) antibodies are most commonly detected in pernicious anemia, chronic atrophic gastritis type A, and autoimmune thyroid disorders.

This panel is suitable for individuals with persistent gastrointestinal symptoms, unexplained iron or vitamin B12 deficiency anemia, neurological symptoms related to B12 deficiency, or suspected autoimmune gastrointestinal disease. It is also useful in individuals with a family history of autoimmune disorders or when previous IgA-based celiac tests are negative but clinical suspicion for celiac disease remains high.

Fasting (8-12 hours) is preferred for this test, or follow your doctor’s advice. Continue eating foods containing gluten if testing for diagnosis, unless your doctor advises otherwise.

Inform your doctor about all your medications, as some can affect the test results, potentially requiring dosage adjustments or temporary discontinuation. Always discuss your test results with your doctor, as ranges can vary by lab and individual health needs.