Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA near me in Bangalore Rural
Understanding Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA in Bangalore Rural
What is Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA in Bangalore Rural?
The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA is a qualitative blood test tailored to detect specific antibodies targeting cytoplasmic proteins within human neutrophils. These antibodies play a critical role in autoimmune vasculitis, a group of autoimmune disorders that causes inflammation (swelling) of the blood vessels such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). The test uses the Immunofluorescence Assay (IFA) method to detect the presence of ANCA. This test is typically suggested when patients present with symptoms suggestive of vasculitis, such as persistent fever, weight loss, fatigue, joint pain, skin rash, and organ involvement (e.g., kidney or lung). The profile includes the MPO (p-ANCA) and PR3 (c-ANCA) tests that identify specific types of ANCA associated with different vasculitis types and a less specific Atypical ANCA test for detailed diagnosis of vasculitis. Early detection using the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test facilitates prompt treatment and helps prevent complications in autoimmune vasculitis.
What does Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA measure?
Contains 3 tests
MPO (p-ANCA)
The MPO (p-ANCA) test detects antibodies in the blood that target myeloperoxidase (MPO), a protein found in certain white blood cells. These antibodies are commonly associated with autoimmune diseases like Microscopic Polyangiitis (MPA) and Churg-Strauss Syndrome, which cause inflammation in small blood vessels. A positive MPO (p-ANCA) test helps doctors diagnose these conditions, differentiate them from other similar health issues, and guide appropriate treatment for better management.
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PR3 (c-ANCA)
The PR3 (c-ANCA) test detects antibodies in the blood that target proteinase-3 (PR3), a protein found in certain white blood cells. These antibodies are commonly associated with autoimmune diseases like Granulomatosis with Polyangiitis (GPA), which causes inflammation in blood vessels and affects organs such as the kidneys, lungs, and sinuses. A positive PR3 (c-ANCA) test helps doctors diagnose these conditions, distinguish them from other similar health issues, and guide the appropriate treatment for better disease management.
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Atypical ANCA
The Atypical ANCA (Anti-Neutrophil Cytoplasmic Antibodies) test measures the presence of specific antibodies in the blood that target proteins in neutrophils, a type of white blood cell. These antibodies are often linked to autoimmune conditions such as Churg-Strauss Syndrome, Ulcerative Colitis, autoimmune hepatitis and certain types of vasculitis. Unlike the typical ANCA test, which detects antibodies against proteins like proteinase 3 (PR3) and myeloperoxidase (MPO), the atypical ANCA test looks for antibodies against other antigens. This test is primarily used in diagnosing autoimmune conditions like vasculitis, particularly those that may not show up with other ANCA testing, helping doctors identify and manage these conditions more accurately.
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