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Dual Marker Test

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Dual Marker Test

Overview of Dual Marker Test

What is Dual Marker Test?

Dual marker test is also known as Double Marker Test. This test measures the levels of Beta Human Chorionic Gonadotropin (beta-hCG) and Pregnancy Associated Plasma Protein (PAPP-A) in blood. It is generally advised for women who are above the age of 35 years as they fall in risk of delivering a baby with Down’s syndrome. Apart from that, it is advised for younger women as well. This test helps in screening the fetus for any abnormalities before birth. It is done from 8 weeks to 14 weeks of pregnancy.

Sample Type

The sample type collected for Dual Marker Test is: Blood

Preparation for Dual Marker Test

  • Please keep the hard copy of your latest pregnancy ultrasound report ready at the time of your test..

Why Get Tested for Dual Marker Test?

  • To detect Down’s syndrome

  • To detect Trisomy 18

  • Ladies having a family history of any of these syndromes

Understand more about Dual Marker Test

This test measures the levels of beta hCG and PAPP-A in blood with the ultrasound test. Beta hCG is a hormone which is produced by the cells in the developing placenta during pregnancy. The levels of beta hCG increases in early pregnancy. The role of beta hCG in early pregnancy is to maintain the function of corpus luteum (the hormone-secreting structure that develops in an ovary). During the first three weeks production of beta hCG increases reaching to peak levels at 10th week (from the last menstrual cycle). After that, the levels of beta hCG start to fall to negligible within a few weeks after delivery.

PAPP-A is secreted by the placenta and its levels increase with duration of pregnancy. Variety of tissues express PAPP-A at very lower levels. Plaques which are not stable in coronary arteries also express PAPP-A in high levels.

Dual marker test is done along with Nuchal Translucency test to confirm the diagnosis of any genetic abnormality. 

Nuchal Translucency (NT) is a measurement of the fluid beneath the skin along the back of the baby's neck. NT is measured by ultrasonography.

What Results of Dual Marker Test mean?


All women should be screened for dual marker test in pregnancy for any pre-birth abnormalities irrespective of age. The ideal duration of this test is between 10 - 13 weeks of pregnancy. But it can be done between 9 - 13.6 weeks of pregnancy.

Patient Concerns about Dual Marker Test

Frequently Asked Questions about Dual Marker Test

Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle attached is used to withdraw blood sample from a blood vessel in your arm generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood and hence makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample once collected is then sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, as this test involves a needle prick to withdraw the blood sample, rarely, a patient may experience increased bleeding, hematoma (blood collection under the skin) formation, bruising or infection at the site of needle prick.
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Provided By



Sahyadri Speciality Labs is committed to provide the highest quality of Medical Laboratory services. There is a continual effort to ensure that the staff of the lab understands the Quality Policy & all the quality documentation, as well as follows the Quality manual and implements the Quality System Procedures all the time. By employing QMS, the lab strives to achieve the highest standard of service to provide the most reliable results, nearest to the true value and at most competitive rates. The lab is committed to good & ethical professional practices giving highest priority to client’s confidentiality and ensuring the reporting of the test values without any bias or influence. The lab implements the QMS so as to conform to ISO 15189:2007 and NABL 112 with the objective of Reducing reporting errors to the minimum, Minimizing customer complaints, Achieving maximum growth of the lab.
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