What is Transcobalamin?
Vitamin B12 Binding Capacity Unsaturated (Transcobalamin), binds and transports vitamin B12 in the circulation. Increased concentrations are associated with patients with myeloproliferative disorders. Decreased concentrations are seen in individuals with Megaloblastic anemia or Transcobalamin deficiency.
Why is Transcobalamin done?
- If you have symptoms of gastro intestinal disease like difficolty gaining weight, repeated diarrhea and/or vomiting, dizziness
- If you have signs or symtoms indicative of vitamin B12 deficinecy anemia like pale skin, dizziness, oral olcers, forgetfolness, confusion, rapid heart beat, poor appetite
- If you have symptoms like tingling numbness in hands/feet, muscle twitching
- If you have symptoms of liver disease or history of alcoholism
Interpreting Transcobalamin results
- High levels of transcobalamine are rare and occur due to excessive nutritional supplements or injections
- Low levels of transcobalamine usually indicate megaloblastic anemia due to vitamin B12 deficiency which can be due to poor intake in diet, poor absorption from gut like Celiac disease