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Content created by
Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Circulating Immunocomplex

(CIC)
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation required

Understanding Circulating Immunocomplex


What is Circulating Immunocomplex?

The Circulating Immunocomplex test is conducted to determine the severity of the immune-complex disease. This test is advised by doctors when there is improper immune system functioning. The noncovalent union of antigen and antibody forms circulating immune complexes (CICs), a diverse collection of immunoreactions. The synthesis, immunochemistry, biology, and clearance of these soluble reactants are influenced by many factors.

The role of our immune system is to safeguard the body from bacteria and viruses by producing proteins called antibodies. Antibodies form in response to antigens, which are different proteins, unlike naturally occurring proteins. When many antigen-antibody complexes multiply in the body, it results in immune-complex reactions. Immune complexes are seen in individuals with autoimmune disorders and viral and infectious diseases.

What is Circulating Immunocomplex used for?

  1. To evaluate symptoms of autoimmune diseases, allergic diseases; viral, bacterial infections and malignancies
  2. To gauge the severity of immune complex diseases by demonstrating circulating immune complexes in the blood
  3. To monitor the response to therapy provided for immune complex diseases

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