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Thyroid Stimulating Hormone

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Overview
Interpreting Results
FAQ's
Thyroid Stimulating Hormone

Overview of TSH

What is TSH?

Thyroid Stimulating Hormone (TSH) is a hormone secreted into the blood by Pituitary gland. TSH signals thyroid gland (a small, butterfly-shaped gland located in front of the neck) to release the thyroid hormones into the blood. The Thyroid Stimulating Hormone (TSH) Test measures the levels of TSH in the blood.

Why is TSH done?

  • To diagnose any suspected thyroid diseases (Hypothyroidism or Hyperthyroidism)

  • To monitor the effect of treatment in patients with thyroid diseases, e.g. in case of hypothyroid patients receiving various thyroid hormone preparations: Low values are found in states of high doses

  • To screen for any thyroid diseases during pregnancy

  • To screen for any thyroid diseases in newborns




What does TSH Measure?

Thyroid Stimulating Hormone (TSH) test measures the amount of TSH in your blood which helps to find out if the thyroid gland is working normally or not. Low TSH levels indicate hyperthyroidism and high TSH levels indicate hypothyroidism.

In case of hyperthyroidism, the thyroid gland produces very high amounts of thyroid hormones (T3 and T4) and you may experience symptoms of weight loss, rapid heartbeat, tremors, sweating, anxiety, increased sensitivity towards heat, etc. In case of Hypothyroidism, there is a decrease in the production of thyroid hormones (T3 and T4) which may cause weight gain, fatigue, slow heart rate, increased sensitivity towards cold, depression, dry and thin hair, etc.

There is a feedback system in the body to maintain stable amounts of the thyroid hormones (T3 and T4) in the blood. TSH signals the thyroid gland to make and release the thyroid hormones (T3 & T4) into the blood when the level of thyroid hormones is low and can also signal the thyroid gland to lower the production of thyroid hormones when the level of thyroid hormones is very high. So, when the thyroid hormone (T3 and T4) levels decrease, the pituitary gland is stimulated to release TSH and this high TSH level, in turn, stimulates thyroid gland to release more thyroid hormone (T3 & T4) from the thyroid gland and the vice-versa happens when the thyroid hormone levels are very high.




Preparation for TSH

  • No special preparation required

Sample Type for TSH

The sample type collected for Thyroid Stimulating Hormone is: Blood

Interpreting TSH results

Interpretations

The TSH normal range may vary from lab to lab. 

The TSH normal range for different age groups is given below:

Patients (Age)                                            TSH Normal Range

Premature Infants (28-36 Weeks)

 1st Week of Life

0.20-27.90 mIU/L

Term Infants (>37 Weeks)

 Serum or Cord Blood

1.00-39.00 mIU/L

 1-2 Days

3.20-34.60 mIU/L

 3-4 Days

0.70-15.40 mIU/L

 5 Days-4 Weeks

1.70-9.10 mIU/L

 1-11 Months

0.80-8.20 mIU/L

 1-19 Years

0.50-4.30 mIU/L

 ≥20 Years

0.40-4.50 mIU/L

Pregnancy

 First Trimester

0.26-2.66 mIU/L

 Second Trimester

0.55-2.73 mIU/L

 Third Trimester

0.43-2.91 mIU/L


  • If your TSH level is increased, it usually indicates that you have hypothyroidism. Hashimoto’s thyroiditis is the most common cause of primary hypothyroidism. 
  • If your TSH level is decreased, it usually indicates hyperthyroidism. Graves' disease, multinodular goiter, toxic nodule are some of the common causes of hyperthyroidism. 

Note: TSH normal range levels show circadian variation (fluctuates during the 24-hour cycle), reaching peak levels between 2-4 am and are at a low between 6-10 pm.




Answers to Patient Concerns & Frequently Asked Questions (FAQs) about TSH

Frequently Asked Questions about Thyroid Stimulating Hormone

Q. What is Hyperthyroidism?
Hyperthyroidism is a condition in which the thyroid gland is overactive. This leads to an increased production of thyroid hormones by the thyroid gland. Causes of Hyperthyroidism include Graves’ disease, multinodular goiter, thyroid nodules, toxic adenoma, inflammation of the thyroid, overconsumption of iodine, and excess of synthetic thyroid hormone. Diagnosis of this condition can help relieve the symptoms and prevent long-term complications.
Q. What are the symptoms of Hyperthyroidism?
Symptoms of Hyperthyroidism include: Rapid heartbeat (tachycardia) — commonly more than 100 beats/minute — irregular heartbeat (arrhythmia) or pounding of your heart (palpitations), sudden weight loss, nervousness, anxiety, irritability, tremor (usually a fine trembling in your hands and fingers), changes in menstrual patterns, increased sensitivity towards heat, changes in bowel patterns (especially more frequent bowel movements), an enlarged thyroid gland (goiter) which may appear as a swelling at the base of your neck, increased appetite, sweating, fatigue, muscle weakness, sleep disturbances, skin thinning, fine and brittle hair.
Q. What is Hypothyroidism?
Hypothyroidism, also called underactive thyroid or low thyroid is a condition in which the thyroid gland does not produce enough thyroid hormones. It can be commonly caused by low intake of iodine in diet or Hashimoto's thyroiditis (an autoimmune disease). Other less common causes include previous treatment with radioactive iodine, injury to the pituitary gland which secretes TSH, intake of certain medicines, previous thyroid surgery or improper functioning of thyroid gland since birth.
Q. What are the symptoms of Hypothyroidism?
Symptoms of Hypothyroidism include: Tiredness (fatigue), constipation, feeling cold, dry skin, weight gain, muscle weakness, decreased sweating, depression, slower heart rate, increased blood cholesterol levels, pain and stiffness in your joints, impaired memory, problems of infertility or menstrual changes, muscle stiffness, aches, and tenderness, hoarseness, puffy face, dry and thin hair.
Q. Are there any special precautions that need to be taken before the test?
Inform the doctor if you are taking any medicine or herbal product since some medicines like birth control pills, estrogen, Lithium, Prednisone, Amiodarone, etc. might interfere with the test results. A recent X-ray with iodine dye (contrast) or test using radioactive materials may also affect the results. Moreover, TSH levels show circadian variation (fluctuates during the 24 hour cycle) hence, sample for TSH test should be given at the same time in follow up cases.
Q. What additional tests your doctor may ask for in case the TSH levels are not in the normal range?
If the TSH levels are not in the normal range, your doctor may ask for the following tests to establish the diagnosis of a suspected disease: T4 thyroid hormone test, T3 thyroid hormone test, Thyroid Hormone Binding Globulin (THBG) test, and Thyroid profile.
Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle is used to withdraw blood sample from a blood vessel in your arm generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood. This makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample once collected is then sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
Q. How can hyperthyroidism affect a pregnant woman and her baby?
An untreated hyperthyroidism during pregnancy can lead to miscarriage, premature birth, low birth weight of the baby, preeclampsia (a very high rise in blood pressure in late pregnancy), thyroid storm (a sudden, severe worsening of symptoms of hyperthyroidism) and congestive heart failure.
Q. How can hypothyroidism affect a pregnant woman and her baby?
An untreated hypothyroidism during pregnancy can cause preeclampsia (a very high rise in blood pressure in late pregnancy), anemia, miscarriage, low birthweight, stillbirth (death or loss of a baby before or during delivery) and rarely, congestive heart failure. These problems are noticed mostly as a result of severe hypothyroidism. The mother’s thyroid hormones play an important role in the development of baby’s brain and nervous system, untreated hypothyroidism, especially during the first trimester can cause low IQ and other problems with normal development.
Q. What are the causes of high TSH in a newborn?
Congenital hypothyroidism is an important cause of elevated thyroid-stimulating hormone (TSH) in newborns. Other causes of an elevated TSH level include transient hypothyroidism due to neonatal illness, premature birth, excess or deficiency of iodine. In case the mother has some underlying thyroid disease or is under medication which affects thyroid hormone levels, TSH levels could increase.
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Gen-X Diagnostics is a unit of ARA Healthcare Pvt. Ltd. founded by leading applied research scientist Dr. Rama Mukherjee. Gen-X specializes in the field of molecular diagnostics, focusing on the development of genetic, biological and molecular diagnostic services. It is one of the first of its kind R&D Company focusing on development of genetic, biological and molecular diagnostic services with an intention to assisting its global partners in shortening the cycle and lowering the cost of drug discovery and development by providing cost effective and efficient co-development and outlicencing solution. Gen X Diagnostics is a unique leading Molecular Diagnostics in India offering a wide range of tests for infectious diseases, transplantation medicine, prenatal diagnostics, cancer, genetic disorder, metabolic and hormonal disorders. Gen-X Diagnostics has started its diagnostics operation from Dec 2007. We do reflect a commitment to improving the lives through the delivery of innovative diagnosis and therapeutic products that enable and provide optimal care.

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