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Dr. Shreya Gupta
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Double Marker Test- First Trimester in Navi Mumbai

Also known as Dual Marker Test, Maternal Serum Screening (MSS) - First Trimester
You need to provide
Blood
This test is for
Female
Test Preparation
  1. Provide information like maternal date of birth (dd/mm/yy), last date of the menstrual cycle, ultrasound status, number of fetuses (Single/Twins), diabetic status, body weight in Kg, and previous history of IVF, smoking, and Trisomy 21 pregnancy at the time of sample collection for filling out a maternal serum screen requisition form, which is mandatory for sample collection. Also, keep the hard copy of your latest pregnancy ultrasound report (CRL, NT/NB, or Level 1) and maternal screen details (LMP, DOB, Body Weight, Diabetic status & IVF) ready at the time of the test.
  2. The test is valid between 9 to 13 weeks of gestation (ideal for combined risk assessment between 11 to 13 weeks).

Understanding Double Marker Test- First Trimester in Navi Mumbai


What is Double Marker Test- First Trimester in Navi Mumbai?

A Double Marker Test- First Trimester is a crucial part of early prenatal assessment available at an affordable price in Navi Mumbai with Tata 1mg Labs. Prenatal care is vital for a healthy pregnancy and successful childbirth, and early screenings like Double Marker Test- First Trimester are central to identifying potential health concerns. This test is typically conducted between the 11th and 13th weeks of pregnancy and is recommended for all pregnant women.

A Double Marker Test- First Trimester primarily focuses on two biomarkers and screens the fetus for two of the most common chromosomal abnormalities: Down syndrome and Edwards' syndrome. These conditions result from extra copies of chromosomes 21 and 18, respectively, and affect the baby's physical and intellectual development. Therefore, their early detection is vital for ensuring comprehensive prenatal care and addressing potential health challenges effectively. Usually, no special preparation is required for Double Marker Test- First Trimester. You may eat and drink normally as per your daily routine.

The levels of these markers, combined with maternal age and ultrasound findings, provide a risk assessment for chromosomal abnormalities. However, remember that this is just a screening test and not a diagnostic test, meaning it does not determine whether your baby has abnormalities; instead, it tells whether the unborn baby is at risk of developing certain abnormalities. Further testing is required to confirm the diagnosis.

What does Double Marker Test- First Trimester measure?

The test is named “Double Marker” or “Dual Marker” as it primarily focuses on two biomarkers associated with chromosomal abnormalities: free beta-hCG (human chorionic gonadotropin) and PAPP-A (pregnancy-associated plasma protein-A). 

The placenta secretes free beta-hCG hormone during the pregnancy period. It helps provide nutrition to the developing fetus and can be detected in the blood 8-11 days after conception. Its levels continuously double every 48–72 hours, and peak levels can be seen during weeks 8–11 of gestation. Afterward, the HCG levels decrease and remain stable for the rest of the pregnancy. Higher than normal levels of this hormone after 11 weeks of gestation indicate the risk of Down syndrome.

PAPP-A is a protein produced by the placenta that is needed for the implantation and maintenance of a healthy placenta (afterbirth). Low levels of PAPP-A before the 14th week of pregnancy suggest an increased risk of fetal chromosomal abnormalities.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Double Marker Test- First Trimester in Navi Mumbai


Frequently Asked Questions about Double Marker Test- First Trimester in Navi Mumbai

Q. Is there any risk associated with this test?

There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.

Q. Is a Dual Marker Test especially advised for pregnant ladies above the age of 35 years?

No, this test is also advised for younger women. It helps in screening any birth abnormalities in the fetus before birth. However, after the age of 35 years, the risk of Down syndrome increases, especially in women who have a family history of any birth defects, have given birth to a child with any birth defects previously, or have a history of insulin-dependent type 1 diabetes.

Q. What is the importance of ultrasound in a Dual Marker Test?

An ultrasound is usually advised before a Dual Marker Test. Based on the results of the ultrasound, your doctor will advise a Double Marker Test- First Trimester.

Q. What are the advantages of a Dual Marker Test?

When a Dual Marker Test is done earlier in pregnancy, it helps you to go for other diagnostic tests if the results come back positive. This will allow you and the doctor to make early decisions if needed.

Q. What is Down syndrome?

It is a genetic disorder in which extra genetic material from chromosome 21 gets transferred to the fetus. This transfer affects the development of the fetus leading to abnormal development both physically and mentally. The affected baby will have a small head and short neck, obliquely positioned eyes looking in an upward direction, large tongue coming out of the mouth, flat face, wide hands with short fingers, and lack of muscle tone.

Q. What is Edwards' syndrome?

It is also known as Trisomy 18 which is caused by the development of an extra chromosome 18. Because of this, the normal pattern of development in the baby gets disturbed even before its birth. The effects caused by Trisomy 18 are very complicated compared to Down syndrome. The effects are so severe that it can cause stillbirth (death at the time of birth) of the child.

Q. What is beta hCG?

Beta hCG refers to Beta human Chorionic Gonadotropin. It is a hormone that is produced by the cells in the developing placenta during pregnancy, and its levels increase in the early phase of pregnancy. The role of this hormone is to maintain the function of the corpus luteum (the hormone-secreting structure that develops in an ovary).

Q. What is a Double Marker Test- First Trimester, and why is it performed?

A Double Marker Test- First Trimester is a prenatal screening test that assesses the risk of chromosomal abnormalities in the developing fetus. It is performed to detect potential genetic conditions such as Down syndrome and Edwards’ syndrome.

Q. How early can a Dual Market Test be conducted during pregnancy?

A Dual Marker Test is typically conducted during the first trimester of pregnancy, i.e., between weeks 9 and 13.

Q. What chromosomal abnormalities are screened by a Double Marker Test- First Trimester?

A Double Marker Test- First Trimester primarily screens for Down syndrome (Trisomy 21) and Edwards’ syndrome (Trisomy 18).

Q. Can a Double Marker Test- First Trimester identify the specific chromosomal abnormalities in the fetus?

A Double Marker Test- First Trimester is a screening test and not a diagnostic test, meaning it screens for the risk of chromosomal abnormalities and doesn’t identify the specific abnormality. Confirmatory tests are required for a definitive diagnosis.

Q. What if a Dual Marker Test is missed?

Suppose you miss the recommended Dual Marker Test time frame; in that case, your doctor may recommend alternative tests, such as a quad marker screening test (typically performed between the 15th and 21st week of pregnancy), depending on the stage of pregnancy.

Q. What is the difference between a Double Marker Test- First Trimester and an NT scan?

A Double Marker Test- First Trimester is a blood test, whereas an NT scan is an ultrasound. The doctor recommends both these tests during the first trimester to screen for the possible risk of chromosomal abnormalities in the unborn child.

Q. Should a Double Marker Test- First Trimester be done on an empty stomach?

This test is a non-fasting blood test. Unless the doctor instructs otherwise, you can eat or drink normally before the test.

Q. Can I book a Double Marker Test- First Trimester in Navi Mumbai?

Yes, you can book a Double Marker Test- First Trimester in Navi Mumbai with Tata 1mg Labs. The test can be booked easily, is affordable, and comes with an easy-to-understand report.

Q. Is home sample collection possible for a Double Marker Test- First Trimester in Navi Mumbai?

Yes, home sample collection is possible for a Double Marker Test- First Trimester in Navi Mumbai with Tata 1mg Labs. You can also choose a date and time that suits your schedule for sample collection.

Q. How can I book a Dual Marker Test with Tata 1mg Labs in Navi Mumbai?

The booking process for a Dual Marker Test with Tata 1mg Labs in Navi Mumbai is straightforward and hassle-free. Follow these steps to schedule a test online: 1). Go to the Lab Tests section on the Tata 1mg website. 2). Add your preferred test to the shopping cart. 3). Choose a time and day that works for you as long as you also take the essential prerequisites into account. 4). A confirmation notification will be sent to you with all the details once the booking is complete.

Q. What is the cost of a Double Marker Test- First Trimester in Navi Mumbai?

Tata 1mg Labs allows you to book tests at an affordable price in Navi Mumbai. A Double Marker Test- First Trimester can be booked at a pocket-friendly budget of Rs. 1729.

Q. How long does it take Tata 1mg Labs to provide the reports of a Double Marker Test- First Trimester in Navi Mumbai?

We at Tata 1mg Labs recognize the value of prompt results. We strive to deliver test results with quick turnaround times so you can receive the information promptly. The reports of a Dual Marker Test in Navi Mumbai are often provided in 72 hours.
+ more

Double Marker Test- First Trimester test price for other cities


Price inBangaloreRs. 1729
Price inGurgaonRs. 1729
Price inNew DelhiRs. 1729
Price inPuneRs. 1729
Price inMumbaiRs. 1729
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References

  1. Wald N, Densem J, Stone R, Cheng R. The use of free beta-hCG in antenatal screening for Down's syndrome. Br J Obstet Gynaecol. 1993 Jun;100(6):550-7. [Accessed 22 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/7687460/ External Link
  2. Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy-associated plasma protein A as predictors of pregnancy complications. BJOG. 2000 Oct;107(10):1265-70. [Accessed 22 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/11028579/ External Link
  3. Mirsafaie M, Moghaddam-Banaem L, Kheirollahi M. The Relationship between Screening Markers in the First Trimester of Pregnancy and Chromosome Aberrations. Int J Prev Med. 2022 Apr 27;13:81. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188895/ External Link
  4. Shah KH, Anjum A, Nair P, Bhat P, Bhat RG, Bhat S. Pregnancy-associated plasma protein A: An indicator of adverse obstetric outcomes in a South India population. Turk J Obstet Gynecol. 2020 Mar;17(1):40-45. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171539/ External Link
  5. Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. 2013 Jan;28(1):3-12. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547446/#:~:text=Decreased%20levels%20of%20PAPP%2DA,increased%20risk%20of%20Down%20syndrome. External Link
  6. Commit to Healthy Choices to Help Prevent Birth Defects [Internet]. CDC; 28 June 2023 [Accessed 22 Sept. 2023]. Available from: https://www.cdc.gov/ncbddd/birthdefects/prevention.html External Link
  7. Infections in pregnancy that may affect your baby [Internet]. CDC; 10 March 2021 [Accessed 22 Sept. 2023]. Available from: https://www.nhs.uk/pregnancy/keeping-well/infections-that-may-affect-your-baby/ External Link
  8. Institute of Medicine (US) Committee on Improving Birth Outcomes; Bale JR, Stoll BJ, Lucas AO, editors. Reducing Birth Defects: Meeting the Challenge in the Developing World. Washington (DC): National Academies Press (US); 2003. 3, Interventions to Reduce the Impact of Birth Defects. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK222083/ External Link

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