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Vitamin D (25-OH)

1150805
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4.2
NABL, ISO
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Overview
Interpretations
FAQ's
Vitamin D (25-OH)

Overview of Vitamin D (25-OH)

What is Vitamin D (25-OH)?

Vitamin D helps our body absorb calcium and phosphorus, and maintain strong bones and teeth. Vitamin D (25-OH) test measures the level of Vitamin D (25-OH) in the blood which is a useful indicator of osteoporosis (bone weakness), rickets (bone malformation), and osteomalacia.

Sample Type

The sample type collected for Vitamin D (25-OH) is: Blood

Preparation for Vitamin D (25-OH)

  • No special preparation required

Why Get Tested for Vitamin D (25-OH)?

To determine vitamin D deficiency when calcium level is low or a person has symptoms of vitamin D deficiency such as bone malformation in children (rickets) and bone weakness, softness, or fracture in adults (osteomalacia).

·       Before starting therapy for osteoporosis.

·       To monitor the adequacy of treatment in patients who are receiving Vitamin D supplements, calcium, phosphorus, and/or magnesium supplements.

·       Diagnose/monitor problems with the parathyroid gland functioning since the parathyroid hormone (PTH) is essential for vitamin D activation.

·       Monitor the health status of individuals with diseases that interfere with fat absorption, such as cystic fibrosis and Crohn’s disease and in patients who have undergone gastric bypass surgery.



Understand more about Vitamin D (25-OH)

Two forms of vitamin D can be measured in the blood, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. The 25-hydroxyvitamin D is the major form found in the blood and is the relatively inactive precursor to the active hormone, 1,25-dihydroxyvitamin D. Because of its long half-life and higher concentration, 25-hydroxyvitamin D is commonly measured to assess and monitor vitamin D status in individuals.

The 25-hydroxyvitamin D test is done to determine the level of Vitamin D in your blood, whether it is low or higher than normal. A low blood level of 25-hydroxyvitamin D can be seen if a person is not getting enough exposure to sunlight or enough dietary vitamin D to meet his or her body's demand or if there is a problem with its absorption from the intestines (cystic fibrosis, Crohn’s disease, who have undergone gastric bypass surgery). Sometimes, drugs used to treat seizure (Phenytoin) can cause Vitamin D deficiency by interfering with transformation to 25-hydroxyvitamin D in the liver. Severe liver and kidney diseases can also cause vitamin D deficiency. A high level of 25-hydroxyvitamin D usually reflects excess supplementation of the vitamin.


What Results of Vitamin D (25-OH) mean?

Interpretations

Low vitamin D level than normal reference range indicating vitamin D deficiency can be because of less sun exposure, dietary deficiency or due to decreased absorption from the intestine.

High vitamin D level than normal reference range indicates vitamin D intoxication and is usually due to excess supplementation of the vitamin.

Range:

The normal range of vitamin D is measured as nanograms per milliliter (ng/mL) or nmol/L and can vary from lab to lab.

Level

Reference range (ng/mL)

Severe deficiency

<10 ng/mL

Mild to moderate deficiency

10-24

Optimal

25-80

Potential intoxication

>80

Note:

·       The assay measures both vitamin D2 (Ergocalciferol) and vitamin D3 (Cholecalciferol) metabolites of vitamin D.

·       There can be seasonal variation in 25 (OH) vitamin D level, with values being 40-50% lower in winter than in summer. It is also influenced by sunlight, latitude, skin pigmentation, sunscreen use, and hepatic function.

·       25 (OH) vitamin D levels can vary with age

·       25 (OH) vitamin D level is increased during pregnancy.


Patient Concerns about Vitamin D (25-OH)

Frequently Asked Questions about Vitamin D (25-OH)

Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle attached is used to withdraw blood sample from a blood vessel in your arm generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood and hence makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample once collected is then sent to the laboratory.
Q. Is there any preparation required before the test?
Inform the doctor about any medications you may be taking. No other specific preparations are usually required before this test.
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General Diagnostics Pvt Ltd is a medical technology company and provider of high-end Preventive Screening and Diagnostic tests with a special focus on metabolomics. General Diagnostics Pvt Ltd is also a Technology Solution Provider to laboratories world-wide offering services based on high end chromatographic instruments. Since its inception about a decade ago, General Diagnostics Pvt Ltd has been continually evolving, transforming and thriving in this ever changing field through its innovations, operational efficiency, and creation of breakthrough solutions. General Diagnostics Pvt Ltd has to its credit the world's most comprehensive genetic metabolic screening test, in addition to several other preventive tests which help address health conditions like diabetes, weight problems, food intolerances, allergies and dysbiosis.

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