Test Detail
Interpreting Results
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Content created by
Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Rheumatoid Factor - Quantitative

(RF Quant.)
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This test is for
Male, Female
Test Preparation
  1. No special preparation required


What is Rheumatoid Factor - Quantitative?

Rheumatoid factor (RF) test determines the presence of rheumatoid antibodies in the body. These are the autoantibodies produced by body's own immune system that attack the healthy tissues. Presence of high level of RF antibodies might indicate the presence of serious autoimmune disorders such as rheumatoid arthritis, lupus erythematosus, chronic infections like tuberculosis and leukemia.

Symptoms like joints pain, fatigue, weight loss, fever, weakness, lumps formation may be suggestive of RF antibodies and testing is usually advised in such cases. Some other tests are also recommended in conjunction with RF test to reach a definitive diagnosis.

Why is RF Quant. done?

    • To diagnose rheumatic diseases such as Rheumatoid arthritis

    • To diagnose autoimmune diseases such as Sjogren’s syndrome or Lupus Erythematosus

    • To diagnose chronic infections


    What does RF Quant. Measure?

    Rheumatoid factor (RF) attacks healthy body tissues as it mistakes them for foreign body tissues. It is not found in healthy persons. The presence of RF means that the body has an autoimmune disease such as Rheumatoid arthritis. Symptoms of Rheumatoid arthritis include stiffness of joints especially in morning, pain in joints, underlying skin nodules, loss of bone and swelling of joints.   

    Interpreting RF Quant. results


    High levels of Rheumatoid factor test indicates the high level of rheumatoid factor in the blood which is associated with Rheumatoid arthritis.

    There are other conditions where RF test is positive that include:

    • Sjogren’s syndrome

    • Systemic Lupus erythematosus

    • Inflammatory lung diseases

    • Chronic infections

    • Cancer

    • Mixed connective tissue diseases

    Answers to Patient Concerns & Frequently Asked Questions (FAQs) about RF Quant.

    Frequently Asked Questions about Rheumatoid Factor - Quantitative

    Q. When does the doctor advise Rheumatoid factor test - Quantitative?
    The doctor advises the RF test - Quantitative when signs and symptoms of Rheumatoid arthritis like the stiffness of joints especially in the morning, pain and swelling in joints, underlying skin nodules are noted in the patient. If the X-ray of the patient shows swelling in the joint capsules along with the loss of cartilage and bone, RF test is advised.
    Q. What other tests are advised apart from rheumatoid factor test - Quantitative?
    Apart from Rheumatoid Factor (RF), Anti CCP Antibody test, Antinuclear antibody test, Complete Blood Count, and X-ray are advised. If a patient has positive Anti CCP antibody test as well as RF test it indicates that the patient has rheumatoid arthritis. If the patient has a positive Anti CCP antibody test but a negative RF test, it means that the patient is likely to develop Rheumatoid arthritis in the future. If Anti CCP antibody test is negative but RF test is positive, it can indicate that the patient should be analyzed for other inflammatory conditions as well.
    Q. Is there any risk associated with this test?
    There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
    Q. Is there any special preparation required for the test?
    No, there is no special preparation required for the test.
    Q. What is Rheumatoid arthritis?
    Rheumatoid arthritis is a systemic autoimmune disease which is chronic (from a long time). It causes inflammation, stiffness, pain and disastrous changes in joints of the body. It can occur at any age but the usual age is after 40 years. As compared to men, women are more affected. It can progress slow or fast. But, if untreated can cause disability of the joints.
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    Vivek Shukla
    Very nice experience. Highly recommended.
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    Awesome experience. Pathology test was never so easy.

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