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Thyroxine Binding Globulin

6800
4.1
NABL, ISO
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Overview
Interpreting Results
FAQ's
Thyroxine Binding Globulin

Overview of TBG

What is TBG?

T3 (Triiodothyronine) and T4 (Thyroxine) hormones are produced by the thyroid gland which binds with the proteins produced by the body. However, small amounts of T3 and T4 remains ‘free’ as it does not bind with the proteins. The protein bound T3 and T4 binds to Thyroxine Binding Globulin (TBG). TBG test is done to assess the thyroid tissues. It helps in the diagnosis of other thyroid disorders such as hypothyroidism and hyperthyroidism.This test measures the levels of TBG which helps in assessing thyroid problems.

Why is TBG done?

  • To diagnose hypothyroidism (low levels of thyroid)

  • To diagnose hyperthyroidism (high levels of thyroid)

  • To monitor treatment in patients with thyroid disease


What does TBG Measure?

Thyroxine Binding Globulin (TBG) test measures the levels of TBG which helps in assessing thyroid problems.
TBG is a serum binding protein which has a high affinity to bind to T3 and T4. In the routine, the thyroid gland maintains the level of free hormone i.e. which is not bound to the TBG. This test is done to assess the thyroid tissues. It helps in diagnosing thyroid disorders such as hypothyroidism and hyperthyroidism. The rise in levels is associated with the intake of oral contraceptives or estrogen therapy. Elevated levels of TBG can be seen during pregnancy or if a person has a family history. The decrease in TBG levels is associated with the intake of androgenic steroids, heavy doses of glucocorticoids, liver disease, nephrotic syndrome, congenital TGB variants and hypoproteinemic states


 

Preparation for TBG

  • No special preparation required

Sample Type for TBG

The sample type collected for Thyroxine Binding Globulin is: Blood

Interpreting TBG results

Interpretations

High levels may indicate:

  • Liver disease

  • Acute intermittent porphyria

  • Hypothyroidism


Low levels may indicate:

  • Acromegaly

  • Acute illness

  • Hyperthyroidism

  • Malnutrition

  • Nephrotic Syndrome


Answers to Patient Concerns & Frequently Asked Questions (FAQs) about TBG

Frequently Asked Questions about Thyroxine Binding Globulin

Q. What is Hyperthyroidism?
Hyperthyroidism is a condition in which the thyroid gland is overactive which leads to an increased production of thyroid hormones. Causes of hyperthyroidism include Graves’ disease, multinodular goiter, thyroid nodules, toxic adenoma, inflammation of the thyroid gland, overconsumption of iodine, and excess of synthetic thyroid hormone. Diagnosis of this condition can help relieve the symptoms and prevent long-term complications.
Q. What is Hypothyroidism?
Hypothyroidism, also known as underactive thyroid or low thyroid is a condition in which the thyroid gland does not produce enough thyroid hormones. It can be caused due to low levels of iodine intake in the diet or Hashimoto's thyroiditis (an autoimmune disease). Other less common causes that lead to hypothyroidism include previous treatment with radioactive iodine, injury to the pituitary gland, as a side-effect of certain medicines, previous thyroid surgery or improper functioning of thyroid gland since birth.
Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle is used to withdraw blood sample from a blood vessel in your arm, generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood. This makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution. The needle is then inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample, once collected, is then sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
Q. What additional tests can be performed in case the TBG results are not in the normal range?
If the TBG test results are not in the normal range, your doctor may ask for the following tests: Thyroid profile Free Anti Thyroperoxidase Antibody
Q. Can medicines have any effect on the levels of TBG test?
Yes, certain medicines such as prednisone, phenothiazines, dilantin, depakene, depakote, drugs such as opioids and opiates or hormonal therapy such as estrogen therapy can affect the levels of TBG.
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About R B Diagnostics

RB is your one-stop medical solution provider. We are an NABL accredited pathology with a state-of-the-art radiology setup including MRI and CT Scan unit. We also have polyclinics, pharmacy, physiotherapy units, fertility clinic and diabetic clinic under our umbrella. We have partnered with Roche and BioRAD to provide 100% computerized pathology with error-free setup. Our MRI imaging and CT scan setup provides highest level of service to our patients in a relaxed, caring, and supportive environment. We are one of the only diagnostic imaging centers in PAN INDIA to use such high quality equipment at such affordable costs. And, unlike open or standing MRI devices, our imaging technology provides first-time high quality image results which requires no second opinion. RB Diagnostics have earned a strong and loyal physician referral base in this miraculously small time line. The real credit goes to our specialized staff and a dedicated management. Physicians rely on us for flexible scheduling, ultra-high quality imaging, and rapid diagnostic response by our specialty radiologists. Our staff of nationally recognized, board certified radiologists give you and your physician the confidence that only highly-trained medical professionals are reviewing your medical reports. From our caring and competent staff to our warm and inviting setting, the primary concern of our staff is always patient comfort and convenience. The MRI Center offers evening, weekend, and same-day appointments. Situated at heart of Lake Town with 50+ employees, we are ready to serve the community with next generation diagnosis. The center is designed keeping in mind the comfort of the patients. Our equipments are backed by industry experts who are committed to provide the top most possible quality blended with incomparable service.

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