Test Detail
Interpreting Results

Content created by

Written by
Dr. Betina Chandolia
BDS, MDS - Oral Pathology and Microbiology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
Want to know more?
Read our Editorial Policy

Creatine Kinase

Creatine Kinase
You need to provide
This test is for
Male, Female
Test Preparation
  1. No special preparation required


What is CK?

Creatine Kinase (CK) Test is also known as Total CK, Creatine Phosphokinase, and CPK Test. This test is done to detect and monitor damage to muscle. It is also done to diagnose conditions which are associated with muscle damage and to detect any possible case of heart attack.

Why is CK done?

The Creatine Kinase Test is done:

  • In case of muscle weakness and muscle aches

  • In the case of dark urine

  • To monitor for muscle injury resolution 

What does CK Measure?

The Creatine Kinase Test measures the levels of Creatine Kinase in the blood. Creatine Kinase (CK) is an enzyme which is found in the brain, heart, skeletal muscle, and other tissues. In case of muscle damage, increased amounts of CK are released into the blood. 

In the blood, normally small amount of CK is present which comes from the skeletal muscles primarily. In case of any damage to the muscle or interference with the production of muscle, energy can lead to increased levels of CK. Also, these levels may rise if there is any change with the use of muscle energy. The examples of such conditions include strenuous exercise and myositis (inflammation of muscles). 

Muscle diseases (myopathies) such as muscle dystrophy can also lead to an increase in the levels of CK. However, significantly high levels of CK are observed in Rhabdomyolysis which there is an extreme breakdown of skeletal muscle tissue. 

Interpreting CK results


    The levels for Creatine Kinase in males are usually less than 171 U/L and in females are less than 145 U/L.

    Reference range may vary from lab to lab*

  • A high Creatinine Kinase (CK) generally indicates that there has been recent muscle damage but does not indicate it's exact cause and location. Serial test results that peak and then begin to drop indicate that new muscle damage has diminished while increasing or persistent elevations suggest continued damage
  • Chest pain and increased CK levels indicate that it is likely that a person has recently had a heart attack
  • Moderately increased levels may be seen after strenuous exercise, weight lifting
  • Normal Ck levels indicate that there has been no muscle damage 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about CK

Frequently Asked Questions about Creatine Kinase

Q. How is the blood sample taken?
The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.
Q. Is there any risk associated with the withdrawal of blood sample procedure?
As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.
Q. In which conditions increased Creatine Kinase levels can be seen?
The increased levels of creatine kinase can be seen in case of inherited myopathies, such as muscular dystrophy, trauma, burns, electrocution, and compression muscle injuries. Hormonal disorders such as thyroid disorders, Addison’s disease, or Cushing disease and can also increase the levels of creatine kinase in the body. These increased levels can also be the result of strenuous exercise, prolonged surgeries, seizures, viral infections, bacterial infections, parasitic infections, fungal infections, connective tissue disorders such as lupus, rheumatoid arthritis, celiac disease, renal disease, thrombosis. Along with that, the levels of creatine kinase may increase if there is any effect on the production of muscle energy or there is an increase in requirement of energy with the use any medicine.
Q. What is Rhabdomyolysis?
The rapid breakdown of muscle tissue is known as rhabdomyolysis. It occurs when there is serious physical, chemical, or biological injury to muscles. It may happen due to trauma, crushing injuries, high voltage electrical shock, serious burns, thrombosis, and toxins (e.g., heavy metals, snake venom, and carbon monoxide). Other reasons which can cause rhabdomyolysis include infections, inherited genetic and metabolic disorders affecting muscle, and muscular dystrophy. Conditions like uncontrolled diabetes, hypothyroidism, hyperthyroidism, and drug abuse can equally be a reason for developing rhabdomyolysis.
+ more

Provided by 5 Labs


Orders Delivered
Get the link to download App

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited


Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant


Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

Know More About Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.