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Thyroid profile Total

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Overview
Interpretations
FAQ's
Tests Included
Thyroid profile Total

Overview of Thyroid profile Total

What is Thyroid profile Total?

The Thyroid Profile Total is a group of tests that are done together to detect or diagnose the thyroid diseases. It measures the levels of following three hormones in the blood: Thyroid Stimulating Hormone (TSH), Thyroxine (T4) - Total and TriIodothyronine (T3) - Total.

Sample Type

The sample type collected for Thyroid profile Total is: Blood

Preparation for Thyroid profile Total

  • No special preparation required

Why Get Tested for Thyroid profile Total?

  • To diagnose any suspected thyroid disease (Hypothyroidism or Hyperthyroidism)

  • To monitor treatment in patients with thyroid diseases

  • To investigate the cause of infertility



Understand more about Thyroid profile Total

The thyroid gland (a small, butterfly-shaped gland located in front of the neck) secretes the following hormones:

  • Triiodothyronine (T3)

  • Thyroxine (T4)


Thyroid Stimulating Hormone (TSH), also called Thyrotropin is a hormone secreted into the blood by a gland present in the brain (Pituitary gland) and it tells your thyroid gland to make and release the thyroid hormones (T3 & T4) into your blood. The thyroid gland uses iodine from food to make the thyroid hormones.


The thyroid hormones are essential for growth and metabolism. If the thyroid gland produces very high amounts of these hormones (T3 and T4), you may experience symptoms of weight loss, rapid heartbeat, tremors, sweating, anxiety, increased sensitivity to heat etc. and this is known as Hyperthyroidism.

Also, the decreased production of thyroid hormones (T3 and T4) results in Hypothyroidism which may cause symptoms like weight gain, fatigue, slow heart rate, increased sensitivity to cold, depression, dry and thin hair etc.


There is a feedback system in the body to maintain stable amounts of the thyroid hormones (T3 and T4) in the blood. When thyroid hormone levels decrease, the pituitary gland is stimulated to release TSH. This high TSH in turn leads to the release of more thyroid hormones (T3 & T4) from the thyroid gland and vice-versa.

T3 and T4 circulate in the blood in two forms:

1) Bound form - It is bound to proteins present in blood and this prevents it from entering body tissues. The three main proteins in the blood that the thyroid hormones are bound to are albumin, transthyretin and Thyroxine-binding globulin (TBG), also called Thyroid hormone Binding Globulin (THBG).

 

2) Free form - It enters the body tissues where it's needed

 

The total T3 or total T4 includes both bound and free forms circulating in the blood. Hence, thyroid hormones can be measured as Free T3, Total T3, Free T4 and Total T4.

 

The total T3 and total T4 levels can be affected by the amount of protein available in the blood to bind to them.


What Results of Thyroid profile Total mean?

Interpretations



T3 (Triiodothyronine), Total                 Reference Range(s)





<1 Month

Not established


1-23 Months

117-239 ng/dL



2-12 Years

105-207 ng/dL



13-20 Years

86-192 ng/dL



>20 Years

76-181 ng/dL




T4 (Thyroxine), Total

                                                 4.5-12.0 mcg/dL


Thyroid Stimulating Hormone (TSH)               Reference Range(s)

Premature Infants (28-36 Weeks)

 1st Week of Life

0.20-27.90 mIU/L

Term Infants (>37 Weeks)

 Serum or Cord Blood

1.00-39.00 mIU/L

 1-2 Days

3.20-34.60 mIU/L

 3-4 Days

0.70-15.40 mIU/L

 5 Days-4 Weeks

1.70-9.10 mIU/L

 1-11 Months

0.80-8.20 mIU/L

 1-19 Years

0.50-4.30 mIU/L

 ≥20 Years

0.40-4.50 mIU/L

Pregnancy

 First Trimester

0.26-2.66 mIU/L

 Second Trimester

0.55-2.73 mIU/L

 Third Trimester

0.43-2.91 mIU/L

    Table 1. Interpretation of the Thyroid Profile Test results

    TSH

    T4

    T3

    INTERPRETATION

    Elevated

    Normal

    Normal

    Mild (subclinical) hypothyroidism

    Elevated

    Low

    Low or normal

    Hypothyroidism

    Low

    Normal

    Normal

    Mild (subclinical) hyperthyroidism

    Low

    Elevated or normal

    High or normal

    Hyperthyroidism

    Low

    Low or normal

    Low or normal

    Nonthyroidal illness; hypothyroidism due to the disease involving the pituitary gland

    Normal

    Elevated

    Elevated

    Thyroid hormone resistance (Impaired sensitivity to thyroid hormone)

  • Low T4 and T3 along with high TSH level indicates hypothyroidism. The most common cause of hypothyroidism is Hashimoto thyroiditis 
  • High T4 and T3 along with low TSH indicate hyperthyroidism. The most common cause of hyperthyroidism is Grave’s disease
  • Normal thyroxine (T4) and T3 along with high TSH usually indicates mild or subclinical hypothyroidism 
  • Normal T3 and T4 along with low TSH indicates mild or subclinical hyperthyroidism 

Note: TSH levels show circadian variation (fluctuates during the 24-hour cycle), reaching peak levels between 2 - 4 am and are at a low between 6-10 pm.

Reference Range(s) may vary from lab to lab.


Patient Concerns about Thyroid profile Total

Frequently Asked Questions about Thyroid profile Total

Q. What is Hyperthyroidism?
Hyperthyroidism is a condition in which the thyroid gland is overactive and there is an increased production of thyroid hormones by the thyroid gland. Causes of Hyperthyroidism include Graves’ disease, multinodular goiter, thyroid nodules, toxic adenoma, inflammation of the thyroid, eating too much iodine, and too much synthetic thyroid hormone. Diagnosis of this condition can help to relieve the symptoms and prevent long term complications.
Q. What are the symptoms of Hyperthyroidism?
Symptoms of Hyperthyroidism include: Rapid heartbeat (tachycardia) — commonly more than 100 beats/minute — irregular heartbeat (arrhythmia) or pounding of your heart (palpitations), sudden weight loss, nervousness, anxiety, irritability, tremor (usually a fine trembling in your hands and fingers), changes in menstrual patterns, increased sensitivity to heat, changes in bowel patterns (especially more frequent bowel movements), an enlarged thyroid gland (goiter) which may appear as a swelling at the base of your neck, increased appetite, sweating, fatigue, muscle weakness, sleep disturbances, skin thinning, fine and brittle hair
+ more

Tests Included in Thyroid profile Total(3 tests)

  • Thyroid Stimulating Hormone
  • Thyroxine - Total
  • TriIodothyronine Total

Provided By

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Wellness Pathcare
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