Pregnancy-Associated Plasma Protein-A
What is PAPP-A?
Pregnancy associated plasma protein A (PAPP-A) is a protein which is formed by the placenta and its levels increase with the duration of pregnancy. Variety of tissues express PAPP-A at very lower levels. Plaques which are not stable in coronary arteries also express PAPP-A in high levels. This test measures the levels of Pregnancy Associated Plasma Protein A (PAPP-A) in blood. It is used for prenatal screening in the first trimester of pregnancy.
Why is PAPP-A done?
For prenatal screening in the first trimester of pregnancy
To detect Down syndrome
To detect Trisomy 18
What does PAPP-A Measure?
PAPP-A test measures the levels of Pregnancy Associated Plasma Protein A (PAPP-A) in blood. PAPP-A is a protein which binds to zinc that acts as an enzyme. It is used in prenatal screening in the first trimester of pregnancy and atherosclerosis. If PAPP-A levels are low in pregnant women at 8 - 14 weeks of pregnancy, there is a risk of restriction of intrauterine growth, premature delivery, trisomy 21, preeclampsia (pregnancy induced hypertension) and stillbirth.
This test assesses the risks of disorders like Down's Syndrome (trisomy 21) and Edward's syndrome (trisomy 18). In these syndromes, the levels of PAPP-A decrease and the space at the neck of the fetus is larger than normal.
Interpreting PAPP-A results
High Levels may indicate the following:
Low Levels may indicate the following:
Answers to Patient Concerns & Frequently Asked Questions (FAQs) about PAPP-A
Frequently Asked Questions about Pregnancy-Associated Plasma Protein-A