Test Detail
Overview
Interpreting Results
FAQ's

Content created by

Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
Want to know more?
Read our Editorial Policy

Pregnancy-Associated Plasma Protein-A

(PAPP-A)
ADD TO CART
Pregnancy-Associated Plasma Protein-A
You need to provide
Blood
This test is for
Female
Test Preparation
  1. No special preparation required

Overview


What is PAPP-A?

Pregnancy associated plasma protein A (PAPP-A) is a protein which is formed by the placenta and its levels increase with the duration of pregnancy. Variety of tissues express PAPP-A at very lower levels. Plaques which are not stable in coronary arteries also express PAPP-A in high levels. This test measures the levels of Pregnancy Associated Plasma Protein A (PAPP-A) in blood. It is used for prenatal screening in the first trimester of pregnancy.

Why is PAPP-A done?

  • For prenatal screening in the first trimester of pregnancy

  • To detect Down syndrome

  • To detect Trisomy 18


What does PAPP-A Measure?

PAPP-A test measures the levels of Pregnancy Associated Plasma Protein A (PAPP-A) in blood. PAPP-A is a protein which binds to zinc that acts as an enzyme. It is used in prenatal screening in the first trimester of pregnancy and atherosclerosis. If PAPP-A levels are low in pregnant women at 8 - 14 weeks of pregnancy, there is a risk of restriction of intrauterine growth, premature delivery, trisomy 21, preeclampsia (pregnancy induced hypertension) and stillbirth.

This test assesses the risks of disorders like Down's Syndrome (trisomy 21) and Edward's syndrome (trisomy 18). In these syndromes, the levels of PAPP-A decrease and the space at the neck of the fetus is larger than normal.

Interpreting PAPP-A results


Interpretations

High Levels may indicate the following:

  • Pregnancy

  • Myocardial infarction

  • Unstable angina


Low Levels may indicate the following:

  • Trisomy 18

  • Down Syndrome

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about PAPP-A


Frequently Asked Questions about Pregnancy-Associated Plasma Protein-A

Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle is used to withdraw blood from a blood vessel in your arm. The healthcare provider will tie an elastic band around your arm to make the blood vessels swell with blood. This makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You will feel a tiny pinprick during the procedure. Blood sample once collected will then be sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
Q. Is there any preparation required before the test?
Inform the doctor about the medications you may be taking. No other specific preparations are usually required before this test.
Q. What is Trisomy 18?
It is also known as Edwards Syndrome which is caused by development of extra chromosome 18 which disturbs the normal pattern of development in the baby even before its birth. The effects caused by Trisomy 18 are very complicated as compared to Down syndrome. The effects are so severe that it can cause stillbirth (death at the time of birth) of the child.
Q. Can PAPP-A test found positive in men also?
Yes, it can be found positive in men having acute coronary heart diseases like unstable angina, myocardial infarction or in men having ruptured or unstable plaques in the arteries.
Q. What is Down's syndrome?
It is a genetic disorder in which extra genetic material from chromosome 21 is transferred to the fetus. This transfer affects the development of the fetus leading to abnormal development both physically and mentally. The affected baby will have a small head and short neck, obliquely positioned eyes looking in an upward direction, large tongue coming out of the mouth, flat face, wide hands with short fingers, and lack of muscle tone.
Q. Are there any other tests required with PAPP-A test?
Before going for PAPP-A test, the doctor advises for the ultrasound. Other tests which may be advised are the b-hCG test or Double marker test.
Q. Is PAPP-A test only used for pregnancy?
No, apart from pregnancy, PAPP-A test is found positive in patients of Acute coronary heart disease such as unstable angina, myocardial infarction or in patients having ruptured or unstable plaques in the arteries.
+ more

NABL

ISO

Bioline has a dedicated team of professionals exclusively for quality testing & its maintenance. Bioline has implemented a quality management system that includes right from pre-examination stage with measures on appropriate storage conditions, internal quality control to the process of examination of sample and then to post examination procedures including sample storage, disposal and verifying its integrity. Bioline Laboratory focuses on Quality that offers a rapid, reliable and accurate...
Know More
User Reviews

S
Sushant Suresh More
brilliant
G
Guest
Good
+more

Available at Other Labs



INDIA’S LARGEST HEALTHCARE PLATFORM

150M+
Visitors
25M+
Orders Delivered
1000+
Cities
Get the link to download App
+91
Reliable

All products displayed on 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Enjoy 20% off on allopathy medicines, up to 50% off on health products, up to 80% off on lab tests and free doctor consultations

India's only LegitScript and ISO/IEC 27001 certified online healthcare platform
Know More About 1mg
Access medical and health information

1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1000 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.