What is T3?
Triiodothyronine (T3) is a hormone secreted by the thyroid gland (small, butterfly-shaped gland located in front of the neck). The T3 hormone is essential for growth and metabolism. T3 circulates in the blood in two forms: Free form (FT3) and Bound form. Triiodothyronine (T3) Total Test measures the total levels (both free and bound forms) of Triiodothyronine (T3) hormone in the blood.
Why is T3 done?
To diagnose thyroid diseases (Hypothyroidism or Hyperthyroidism)
To monitor treatment in patients with thyroid diseases
What does T3 Measure?
Triiodothyronine (T3) Total Test measures the total levels (both free and bound forms) of Triiodothyronine (T3) hormone in the blood.
The thyroid gland secretes the following hormones:
Thyroid Stimulating Hormone (TSH) is a hormone secreted into the blood by a gland present in the brain (Pituitary gland) and it tells your thyroid gland to make and release the thyroid hormones (T3 & T4) into your blood. The thyroid gland uses iodine from food to make the thyroid hormones.
The thyroid hormones are essential for growth and metabolism. If the thyroid gland produces very high amounts of these hormones (T3 and T4), you may experience symptoms of weight loss, rapid heartbeat, tremors, sweating, anxiety, increased sensitivity to heat etc. and this is known as Hyperthyroidism.
Also, the decreased production of thyroid hormones (T3 and T4) results in Hypothyroidism which may cause symptoms like weight gain, fatigue, slow heart rate, increased sensitivity to cold, depression, dry and thin hair etc.
There is a feedback system in the body to maintain stable amounts of the thyroid hormones (T3 and T4) in the blood. When thyroid hormone levels decrease, the pituitary gland is stimulated to release TSH. This high TSH in turn leads to the release of more thyroid hormones (T3 & T4) from the thyroid gland and vice-versa.
Majority of the T3 hormone is formed from T4 hormone and a smaller fraction is produced directly by the thyroid gland. T3 hormone circulates in the blood in two forms:
1) Bound form - It is bound to proteins present in blood and this prevents it from entering body tissues. The two main proteins in the blood that the T3 hormone is bound to are albumin and Thyroxine-binding globulin (TBG), also called Thyroid hormone Binding Globulin (THBG).
2) Free form - It enters the body tissues where it is needed and this is the active form. Free Triiodothyronine (FT3) constitutes only 0.3% of the total T3 hormone.
The total T3 includes both bound and free forms circulating in the blood and can be affected by the amount of protein available in the blood to bind to them. The T3 hormone can be measured as Free T3 or Total T3. Triiodothyronine (T3) Total Test measures the total levels (both free and bound forms) of Triiodothyronine (T3) hormone in the blood and is usually done as a part of the Thyroid Profile Total test which includes two more tests: Thyroid Stimulating Hormone (TSH) and Thyroxine Total (T4) hormone.
Interpreting T3 results
T3 (Triiodothyronine), Total Reference Range(s)