Phenytoin

520364
30% Coupon
4.7
NABL, ISO
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Overview
Interpretations
FAQ's

Overview of Phenytoin

What is Phenytoin?

Phenytoin is a drug used in the treatment of seizures as in epilepsy, complex partial seizures, and seizures that occur during or after a neurosurgical procedure. The Phenytoin Test is performed to measure the levels of phenytoin in blood.

Sample Type

The sample type collected for Phenytoin is: Blood

Preparation for Phenytoin

  • No special preparation required

Why Get Tested for Phenytoin?

The Phenytoin Test is performed:

·         To establish the therapeutic dosage for phenytoin in the blood

·         To monitor phenytoin levels at regular intervals to maintain therapeutic concentration after starting treatment

·         To check for phenytoin toxicity if toxicity symptoms appear

Understand more about Phenytoin

Phenytoin is a drug used mainly for the treatment of epileptic seizures. It is also used to treat convulsions and seizures caused due to neurosurgery. It may be prescribed in combination with other anticonvulsant medications like phenobarbital.

Phenytoin taken orally is absorbed in the intestinal tract and goes into the blood. In blood, most of it gets bound to plasma proteins like albumin and only a small portion remains free. Only the free phenytoin remains metabolically active and the phenytoin-protein complex remains inactive. Phenytoin blocks the excessive electrical conductivity between the neurons in the brain during seizures.

Phenytoin levels are affected by a number of factors including liver function, other drugs, levels of plasma proteins that form complex with it, and the age of the patient. Since phenytoin levels need to be maintained within a very narrow therapeutic range in blood, they are monitored regularly during treatment.


What Results of Phenytoin mean?

Interpretations

Therapeutic Range:

Total phenytoin:

10 to 20 µg/ml (Children and adults)

8 to 15 µg/ml (Newborns)

Free phenytoin: 1 to 2 µg/ml


The therapeutic range of phenytoin may vary from person to person and due to a number of other factors. Hence, the therapeutic range is established for the patient at the beginning of treatment.

Lower phenytoin concentration than the therapeutic range makes the drug ineffective in treatment.

Higher phenytoin concentration than the therapeutic range induces symptoms associated with phenytoin toxicity.


Patient Concerns about Phenytoin

Frequently Asked Questions about Phenytoin

Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle attached is used to withdraw blood sample from a blood vessel in your arm generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood and hence makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample once collected is then sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, as this test involves a needle prick to withdraw the blood sample, rarely, a patient may experience increased bleeding, hematoma (blood collection under the skin) formation, bruising or infection at the site of needle prick.
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Provided By

NABL

ISO

Thyrocare Technologies Limited is India's first and most advanced Totally Automated Laboratory having its strong presence in more than 2000 cities / towns in India and internationally. Thyrocare is India's first fully automated diagnostic laboratory with a focus on providing quality at affordable costs to laboratories and hospitals in India and other countries. Thyrocare operates with a Centralized Processing Laboratory (CPL) in Mumbai - India for esoteric tests; and Regional Processing Laboratory in major metro cities of India and other parts of Asia. We have focus on strong technologies, strong brands and strong systems that enable all laboratories to give their clients the best of science and technology at an affordable cost. With a belief that 'Quality' is the heart of any intelligent management, Thyrocare became one of the first Indian diagnostic laboratories to obtain internationally renowned quality accreditations like ISO 9001-2000 rating as early as 2001, which is now escalated to ISO 9001:2008; NABL (National Accreditation Board for Testing and Calibration Laboratories) in 2005 and CAP (College of American Pathologists) certification in 2007.
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