Myasthenia gravis (MG) is characterised by muscle weakness & easy fatigabilitymost commonly due to autoantibody mediated loss of functional acetylcholinereceptors in the postsynaptic membrane of skeletal muscle. ACHR antibodies arenot found in Congenital MG. This assay is used to diagnose Acquired forms of MG(90% positive), for detecting subclinical MG in recipients of D-penicillamine,Thymoma without clinical evidence of MG & Graft versus Host disease. It may alsobe positive in Lambert-Eaton myasthenic syndrome, Autoimmune liver disease &Paraneoplastic autoimmune neurological disorders.
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