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Anti Thyroperoxidase Antibody

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Overview of Anti Thyroperoxidase Antibody

What is Anti Thyroperoxidase Antibody?

Anti thyroperoxidase antibody (TPO) are seen in thyroid diseases. The anti TPO antibody test measures the levels of antibodies directed against thyroid peroxidase, an enzyme found in the thyroid gland. This enzyme plays an important role in the production of thyroid hormones. This test is also known as thyroid peroxidase (TPO) antibody (TPOAb) test, thyroid peroxidase autoantibody test, the antimicrosomal antibody test, and antithyroid microsomal antibody test. The presence of these antibodies would help in diagnosing the reason for low levels of thyroid hormones.

Sample Type

The sample type collected for Anti Thyroperoxidase Antibody is: Blood

Preparation for Anti Thyroperoxidase Antibody

  • No special preparation required

Why Get Tested for Anti Thyroperoxidase Antibody?

  • To diagnose autoimmune disorders of thyroid like Hashimoto's thyroiditis (swelling of thyroid gland resulting in decreased thyroid function), Grave's disease (overactive thyroid gland resulting in overproduction of thyroid hormones) or idiopathic myxedema (associated with low levels of thyroid hormones)

  • To differentiate between autoimmune disorders of thyroid from non-autoimmune disorders such as goiter or hypothyroidism.

  • To diagnose chronic thyroiditis

  • To diagnose subclinical hypothyroidism

Understand more about Anti Thyroperoxidase Antibody

TPO is also known as thyroid peroxidase or iodide peroxidase which is an enzyme mainly expressed in the thyroid gland. The thyroid gland is positioned at the lower part of the neck. TPO is found in the cells of the thyroid follicle where it helps in the production of the thyroid hormones. Its basic function is to oxidize iodide ions to form iodine atoms which assist in the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. TPO is an antigenic determinant of autoantibodies in diseases like autoimmune disorders of the thyroid. These antibodies are called as anti-TPO antibodies (anti-Thyroid peroxidase antibodies) which activates complement and might be associated with dysfunction of thyroid and its pathogenesis. To assess these antibodies, Anti-TPO antibody test is carried out.

What Results of Anti Thyroperoxidase Antibody mean?


Positive tests may indicate the following:

  • Hashimoto’s thyroiditis
  • Grave’s disease
  • Idiopathic Myxedema
  • Postpartum thyroiditis
  • Nontoxic Nodular Goiter
  • Thyroid cancer

Patient Concerns about Anti Thyroperoxidase Antibody

Frequently Asked Questions about Anti Thyroperoxidase Antibody

Q. What is Hypothyroidism?
Hypothyroidism, also called underactive thyroid or low thyroid is a condition in which the thyroid gland does not produce enough thyroid hormones. It can be commonly caused by intake of low iodine diet or Hashimoto's thyroiditis (an autoimmune disease). Less common causes include previous treatment with radioactive iodine, injury to the pituitary gland which secretes TSH, intake of certain medicines, previous thyroid surgery or a lack of a functioning thyroid gland at birth.
Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle attached is used to withdraw blood sample from a blood vessel in your arm generally from the inner side of the elbow area. The doctor, nurse or the phlebotomist will tie an elastic band around your arm which will help the blood vessels to swell with blood and hence makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You may feel a tiny pinprick during the procedure. Blood sample once collected is then sent to the laboratory.
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Clinitech Laboratory Private Limited was registered at Registrar of Companies Mumbai on 19 March, 2010 and is categorised as Company limited by Shares and an Non-govt company. Clinitech Laboratory Private Limited's Corporate Identification Number (CIN) is U85195MH2010PTC201078 and Registeration Number is 201078. Clinitech Laboratory Private Limited registered address on file is AL - 1 / 545 & 546, SECTOR 16, AIROLI, NAVI MUMBAI MH 400708 IN, Navi Mumbai - 400708, Maharashtra, India. Clinitech Laboratory Private Limited currently have 2 Active Directors / Partners: Jagdish Umakant Nayak, Jyoti Jagdish Nayak, and there are no other Active Directors / Partners in the company except these 2 officials. Clinitech Laboratory Private Limited is involved in Community, Personal & Social Services Activity

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