Test Detail
Overview
Interpreting Results
FAQ's

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Written by
Dr. Betina Chandolia
BDS, MDS - Oral Pathology and Microbiology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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NT-Pro BNP

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You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation required

Overview


What is NT-Pro BNP?

NT-Pro BNP Test refers to N-terminal pro b-type natriuretic peptide Test. This test measures the levels of the protein BNP in blood. The NT-Pro BNP is a substance produced by the left ventricle of the heart which helps to relax the blood vessels for maintaining smooth blood flow. 


Why is NT-Pro BNP done?

The NT-Pro BNP test is done to help in the detection, diagnosis, and evaluation of the severity of congestive heart failure (CHF).


What does NT-Pro BNP Measure?

The NT-Pro BNP Test measures the levels of the protein BNP in blood. The NT-Pro BNP (N-terminal pro b-type natriuretic peptide) is a substance secreted by the left ventricle of the heart due to the stretching of the heart chamber while pumping blood. It helps in the relaxation of blood vessels for smooth blood flow. The heart continuously secretes a precursor substance called pro-BNP which is converted to BNP to maintain a low constant level in blood. In case of congestive heart failure, the heart works harder to pump blood causing extra pressure in the heart muscles. This leads to an increase in the production of BNP to help stimulate the blood vessels to relax and reduce the pressure on the heart. This increased production of BNP could be due to other conditions which affect the circulatory system like blockages in blood vessels.

The B-Type Natriuretic Peptide was initially named the Brain Type Natriuretic Peptide since it was first detected in the brain tissues. Later, it was renamed to B-Type to distinguish it from Atrial or A-Type Natriuretic Peptide (ANP), which is another substance with similar function also produced in the heart.


Interpreting NT-Pro BNP results


Interpretations


AGE IN YEARS

97.5th PERCENTILE IN pg/mL

1-3

320

4-6

190

7-9

145

10

112

11

317

12

186

13

370

14

363

15

217

16

206

17

135

18-44

115

45-54

172

55-64

263

65-74

349

>=75

738


Reference range may vary from lab to lab*


In case of congestive failure in first hour or in case of ventricular inflow obstruction, there is lack of rise of N-terminal pro-BNP levels.


Answers to Patient Concerns & Frequently Asked Questions (FAQs) about NT-Pro BNP


Frequently Asked Questions about NT-Pro BNP

Q. What other tests can be prescribed by your doctor in case the results of NT-pro BNP Test are not normal?
The doctor may suggest other tests if the result of Nt-pro BNP Test comes above or below the normal range. These tests include ANP test, lipid profile test, chest X-ray, electrocardiogram, and echocardiogram.
Q. In what conditions can levels of NT-pro BNP increase?
The levels of NT-pro BNP can increase in conditions such as heart failure, asymptomatic left ventricular dysfunction, arterial and pulmonary hypertension, cardiac hypertrophy, valvular heart disease, arrhythmia, and acute coronary syndrome. Along with that, conditions like acute and chronic renal failure, liver cirrhosis, hyperaldosteronism, and Cushing’s syndrome can show increased levels of NT-pro BNP.
Q. How is the blood sample taken?
The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.
Q. Is there any risk associated with the withdrawal of blood sample procedure?
As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.
Q. What are the common symptoms of heart failure?
Heart failure can be indicated by symptoms such as difficulty in breathing, shortness of breath, feeling tired, and swelling (edema) in the feet, ankles, legs, and abdomen.
Q. What is congestive heart failure?
Congestive heart failure is a progressive condition (increase in intensity with time). In this, the heart muscles are unable to efficiently pump blood in sufficient quantities required for the rest of the body. Congestive heart failure can be caused by a number of factors such as high blood pressure (hypertension) and coronary artery diseases, where cholesterol deposition occurs on the inner wall of the blood vessels, causing a blockage in blood supply. It is observed that there are certain conditions which affect the heart valves and make them ineffective, which as a result lead to congestive heart failure. It should be noted that congestive heart failure can also be seen in conditions which are not directly related to the heart such as diabetes, obesity, severe infections, etc.
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