Test Detail
Overview
Interpreting Results
FAQ's

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Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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High Sensitive CRP

(hsCRP)
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High Sensitive CRP
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation required

Overview


What is hsCRP?

C-reactive protein (CRP) is an acute phase reactant, mainly synthesized by the liver. The CRP concentration increases in the blood following the heart attack, inflammation, infection, surgery, trauma, etc. High-sensitivity CRP (Hs-CRP) test measures lower levels of CRP in the blood to predict the risk of Cardiovascular diseases and stroke.

Why is hsCRP done?

  • To evaluate a person's risk for cardiovascular disease and stroke.

What does hsCRP Measure?

High-sensitivity CRP (Hs-CRP) test measures lower levels of CRP in the blood to predict the risk of Cardiovascular diseases and stroke.

Hs-CRP can implicate low level of inflammation. A persistent low level of inflammation can result in a build-up of cholesterol and other lipids and can cause atherosclerosis and narrowing of blood vessels, which is often associated with Cardiovascular diseases (CVD). The hs-CRP test accurately measures low levels of C-reactive protein to identify low but persistent levels of inflammation and thus helps predict a person's risk of developing CVD. High-sensitivity CRP along with lipid profile can be a useful test for screening the risk of CVD, heart attacks, and strokes. Studies have suggested that this test is best suited for people who have a moderate risk of heart attack over the next 10 years.

Therefore, Hs-CRP is generally advised along with other tests such as lipid profile and lipoprotein-associated phospholipase A2 (Lp-PLA2) to provide added information about the risk of heart disease.

Interpreting hsCRP results


Interpretations

A desirable blood level of Hs-CRP is less than 1 mg/ml.

Low risk: less than 1.0 mg/L

Average risk: 1.0 to 3.0 mg/L

High risk: above 3.0 mg/L

Above 10 mg/mL: indicates acute inflammation

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about hsCRP


Frequently Asked Questions about High Sensitive CRP

Q. How is this test performed?
This test is performed on a blood sample. A syringe with a fine needle is used to withdraw blood from a blood vessel in your arm. The healthcare provider will tie an elastic band around your arm to make the blood vessels swell with blood. This makes it easier to withdraw blood. You may be asked to tightly clench your fist. Once the veins are clearly visible, the area is cleaned with an antiseptic solution and then the needle is inserted into the blood vessel to collect the sample. You will feel a tiny pinprick during the procedure. Blood sample once collected will then be sent to the laboratory.
Q. Is there any risk associated with this test?
There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
Q. Is there any preparation required before the test?
Inform the doctor about the medications you may be taking. No other specific preparations are usually required before this test.
Q. Who should get tested for Hs-CRP?
Checking CRP level of entire adult population is not recommended. Adult patients with a risk of heart diseases or family history of heart disease should be advised hs-CRP along with other screening tests.
Q. What does the test result of Hs-CRP mean?
Hs-CRP is a CVD risk screening test and the higher the hs-CRP the higher is the risk of developing heart disease and its complications such as heart attacks, strokes, peripheral vascular disease, and sudden cardiac death. Sometimes, lipid lowering medications may be prescribed in patients with high hs-CRP levels even if their cholesterol levels are not high to reduce their risk of heart disease.
Q. What are symptoms of high C-reactive protein?
There are no specific symptoms of high CRP level as it is not a disease-specific test, instead, the signs and symptoms, if present, will be of any underlying disease condition.
Q. Is Hs-CRP specific for predicting heart diseases?
No, hs-CRP is not specific for predicting heart disease. It is a marker of inflammation and can increase in various other medical conditions such as chronic inflammatory conditions (rheumatological disease, lupus, vasculitis), inflammatory bowel disease, infection (such as pneumonia, tuberculosis), surgery, drug reaction, burns, oral contraceptive pill use, or trauma. Recent studies have studies shown that having CRP in the high normal range may also be associated with other diseases such as colon cancer, complications of diabetes, and obesity.
Q. What is the difference between CRP test and Hs-CRP test ?
The standard CRP test measures markedly high levels of CRP to detect diseases that cause significant inflammation. It measures CRP within the range of 10 to 1000 mg/L. The high-sensitivity CRP test detects lower levels of CRP than the standard CRP test and thus helps in evaluating an individual’s risk of cardiovascular disease (CVD). It measures CRP within the range of 0.5 to 10 mg/L.
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