ALK By IHC & ROS - 1 By IHC
What is ALK By IHC & ROS - 1 By IHC?
ALK stands for the term anaplastic lymphoma receptor tyrosine kinase gene. This test detects particular rearrangements in the ALK gene present in cancer cells and tissue. The presence of these gene alterations makes it more likely that a person suffering from non-small cell lung cancer will respond well to treatments such as targeted drug therapy.
ROS-1 test is done for identifying c-ROS oncogene 1 (ROS1) gene rearrangements in patients suffering from late-stage, lung cancer, or adenocarcinomas that show negative results for negative for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. The ROS1 gene is a receptor tyrosine kinase, a cell surface receptor that has been shown not only to be a key regulator of normal cellular processes, but it also has a crucial role to play in the development and progression of many types of cancer, including lung cancer.
What does ALK By IHC & ROS - 1 By IHC Measure?
1. An ALK or ROS-1 mutation test is usually done after an individual has been diagnosed with non-small cell lung cancer, particularly adenocarcinoma.
2. These tests are also ordered in case of rare ALK or ROS-1 gene mutations that are not detected by routine testing which is only done in case of common mutations.