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Candidiasis, colitis, diarrhoea, indigestion.

How it works

S. boulardii secretes enzymatic proteins, including a protease that degrades Clostridium difficile toxins and a phosphatase that inactivates endotoxins such as the lipopolysaccharide produced by E. coli. It also strengthens tight junctions between enterocytes (reducing chloride secretion), promotes maturation of the intestinal brush border membrane and stimulates production of glycoproteins (including secretory IgA). S. boulardii also promotes production of disaccharidases such as lactase, sucrase, maltase, and N-aminopeptidase in the brush border allowing increased carbohydrate degradation and absorption in patients with diarrhea, and restores normal levels of short chain fatty acids in the colon which are necessary for absorption of water and electrolytes.

Common side effects

Gastrointestinal discomfort


Content on this page was last updated on 17 May, 2016, by Dr. Varun Gupta (MD Pharmacology)