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Leucovorin Calcium



Leucovorin calcium is used to prevent harmful effects of drugs like methotrexate, pyrimethamine, or trimethoprim when it is used to treat certain types of cancer. It is also used to treat anemia (lack of red blood cells) caused by chemotherapy (treatment with cancer medications).

How it works

Leucovorin calcium belongs to the class of medications called as folic acid analogues. It works by protecting healthy cells from the effects of methotrexate, while allowing it to enter and kill cancerous cells. 

Common side effects

Nausea, Acute toxicity, Rash, Stomach upset, Urticaria


Expert advice

  • Administer leucovorin calcium 24 hours after beginning of methotrexate infusion.
  • Do not take more than 25 mg of oral dose.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if patient is allergic to leucovorin calcium or any of its ingredients.
  • Do not given to patient with history of anemia due to vitamin B12 deficiency.
  • Do not given to patient with build-up of fluid in the chest cavity or the stomach area or kidney disease. 
  • Do not given to patient taking fluorouracil.

Frequently asked questions

Leucovorin Calcium

Q. What is leucovorin calcium, its use and its mechanism of action?
Leucovorin calcium is a form of folic acid, a vitamin, which is used as antidote to toxic effects of drugs such as methotrexate, pyrimethamine, or trimethoprim. Leucovorin is also used to treat anemia caused by chemotherapy by helping body to produce and maintain new cells.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)