Zambri 5mg Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Zambri 5mg Tablet may be taken with or without food but, it is better to take it in a dose and duration as advised by the doctor. In case, you have missed any dose than it is better to take another one as soon as you remember it.

The most common side effects of this medicine are peripheral edema, nasal congestion, sinusitis, and flushing. Let your doctor know if any of these side effects bothers you or persists for a longer duration. Dizziness may also occur in some people, so do not drive or do anything that requires mental focus if you experience such symptom.

Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. Patients with liver or kidney disease must be cautious while receiving the prescription, and they must receive regular follow-ups as per the doctor’s advice.

Uses of Zambri Tablet

Pulmonary arterial hypertension (PAH)

Benefits of Zambri Tablet

In Pulmonary arterial hypertension (PAH)

Pulmonary arterial hypertension can cause shortness of breath, tiredness, dizziness, chest pain and swelling in your ankles and legs. It is caused by thickening of walls of the arteries that supply your lungs making it hard for blood to get through. Zambri 5mg Tablet relaxes the blood vessels and can help lower the blood pressure in the arteries of your lungs. You will be able to carry out your daily activities more easily and feel less tired or dizzy.

Side effects of Zambri Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zambri

Peripheral edema
Nasal congestion (stuffy nose)
Sinus inflammation
Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Zambri Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zambri 5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zambri Tablet works

Zambri 5mg Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Zambri 5mg Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zambri 5mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Zambri 5mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Zambri 5mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Zambri 5mg Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Zambri 5mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Zambri 5mg Tablet may be needed. Please consult your doctor.
Limited information is available on use of Zambri 5mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

CAUTION

Zambri 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Zambri 5mg Tablet may be needed. Please consult your doctor.

What if you forget to take Zambri Tablet?

If you miss a dose of Zambri 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Zambri 5mg Tablet

₹140.6/Tablet

Pulmonext 5 Tablet

MSN Laboratories

₹192.2/tablet

37% costlier

Endobloc 5 Tablet

Cipla Ltd

₹175.8/tablet

25% costlier

Ambrican 5 Tablet

Lupin Ltd

₹241/tablet

71% costlier

Quick tips

Your doctor has prescribed Zambri 5mg Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Zambri 5mg Tablet affects you.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Zambri 5mg Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.

Fact Box

Chemical Class

Diphenylmethanes Derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin receptor blocker

Interaction with drugs

Taking Zambri with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Ciclosporin

Brand(s): Imudrops, Neoral, Aurosporine

Life-threatening

Acenocoumarol

Brand(s): Altrom, Cenorol, Cgtrom

Serious

Warfarin

Brand(s): Cofarin, Warf, Uniwarfin

Serious

Phenindione

Brand(s): Dindevan

Serious

View all interactions

Patient concerns

Having high Pulmonary Atrial Hypertension

Dr. Nabajit Talukdar

Cardiology

What medicines r u on

Hiii my wife having hurt patient ( pulmonary hypertension ) she's taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price

Dr. Sfurti Mann

Internal Medicine

This can't be decided online Your doctor is the best judge about your patients pulmonary hypertension

Hello Dr. My Dad is facing High Pulmonary Hypertension of 63 and average is 32. He has liver cirrhosis as well, he is advised for liver transplant. As the PAH is high cannot proceed with the surgery. Can you please advise if there is any way out. Age : 49yrs. Medicines for heart taken at present is : Ambrisentan 5mg Assurance 20mg Trimium Inhaler.

Dr. Nabajit Talukdar

Cardiology

Currently no other treatment apart from ambrisantan n assurance will have to wait n see response to medicines if pulmonary pressure comes down only then surgery possible

User feedback

What are you using Zambri Tablet for?

Pulmonary art*

100%

*Pulmonary arterial hypertension (PAH)

How much was the improvement?

Poor

56%

Average

44%

What were the side-effects while using Zambri 5mg Tablet?

No Side Effec*

67%

Dizziness

33%

*No Side Effect

How do you take Zambri Tablet?

With food

67%

Empty stomach

33%

Please rate Zambri 5mg Tablet on price

Expensive

67%

Not Expensive

22%

Average

11%

FAQs

Q. Can Zambri 5mg Tablet cause liver problems?

Yes, Zambri 5mg Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

Q. How should Zambri 5mg Tablet be taken?

Usually, the doctors advise to take one dose of Zambri 5mg Tablet. You can take it with or without food but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Q. Can I stop taking Zambri 5mg Tablet on my own?

No, you should not stop taking Zambri 5mg Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

Q. What is the most important thing that I should know about Zambri 5mg Tablet?

Zambri 5mg Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Zambri 5mg Tablet. Additionally, during treatment with Zambri 5mg Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.

Q. What are the serious side effects of Zambri 5mg Tablet?

The serious side effects of Zambri 5mg Tablet are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Q. Why have I been prescribed Zambri 5mg Tablet?

Zambri 5mg Tablet is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Zambri 5mg Tablet lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

Q. What are the symptoms of overdose of Zambri 5mg Tablet?

Taking more than the recommended dose of Zambri 5mg Tablet may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 39-50.
Name of medicine. Citywest Business Campus Dublin: GlaxoSmithKline (Ireland) Limited; 2008 [revised 31 Oct. 2018]. [Accessed 01 Apr. 2019] (online) Available from:
Ambrisentan. Uxbridge, Middlesex: GlaxoSmithKline UK; 2008 [revised 31 Oct. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
CiplaMed. Ambrisentan [Prescribing Information]. [Last reviewed: May 2018] [Accessed 09 Jun, 2023] (online) Available from:
(ambrisentan) [Product Information]. [Accessed 09 Jun, 2023] (online) Available from:

Marketer details

Name: Zydus Cadila

Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Country of origin: India

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