X Met P 7.5 mg/1000 mg Tablet

Pioglitazone has been shown to inhibit Liver Cancer (HCC) recurrence in overweight Hepatitis C Virus-infected diabetic patients. It also improved insulin resistance (a state where the body is resistant to the effects and functions of the insulin hormone) in them.

Studies indicate that Vitamin-D combined with Pioglitazone may be more effective in improving Bone Mineral Density and Bone Metabolism than Vitamin-D or Pioglitazone alone in the treatment of Diabetes Mellitus patients with kidney dysfunction (Diabetic Nephropathy).

Combination therapy with Sitagliptin and Pioglitazone leads to a substantial and sustained improvement in glycemic (blood sugar) control compared to the treatment with Pioglitazone alone. This is useful for patients who cannot tolerate Metformin or Sulfonylureas.

Recent evidence suggests that Pioglitazone may be beneficial in Alzheimer's disease (AD), decreasing the cognitive decline early in the disease process. However, larger studies are now in progress to establish the same.

For patients who previously failed oral antidiabetic therapy, the combination of Repaglinide and Pioglitazone have acceptable safety, with greater reductions of glycemic parameters (blood sugar levels) than using either agent alone.

Large population studies indicate that Pioglitazone is associated with an increased risk of bladder cancer. The absence of an association of bladder cancer with the other drug of the same class, Rosiglitazone, suggests that the increased risk is drug specific and not a class effect.

Pioglitazone & Rosiglitazone both belong to a class of antidiabetics called Thiazolidinediones. Rosiglitazone has been removed from the market because using this drug was associated with increased risk of cardiovascular events like heart attack and stroke. This is not seen with Pioglitazone.

Pioglitazone when added to Glimepiride in Patients with Diabetes Mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood pressure control related to a reduction in the insulin resistance.

No. Pioglitazone is not a steroid. It is an anti-diabetic medication which belongs to the class of thiazolidinediones.

Pioglitazone is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Pioglitazone acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.

Pioglitazone cardiovascular safety profile compares favourably with that of Rosiglitazone. Pioglitazone has been found to be associated with bladder tumours but causality assessment has not been proved yet.

Pioglitazone increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Pioglitazone causes increased sodium and water reabsorption from the kidney that contributes to the oedema.

The mechanism behind the link between Pioglitazone use and bladder cancer is still unknown. Studies have suggested that use of Pioglitazone for more than one year results in increased risk of development of tumour of the urinary bladder.

Pioglitazone can cause fluid retention and edema. Consequently, there is a lot of fluid in the body (fluid overload). As a result, it may precipitate heart failure (which worsens with fluid overload in those at risk).

Studies in animals have concluded that Pioglitazone improves the elasticity of the aortic wall ( the aorta is a large blood vessel that arises from the heart and supplies oxygenated blood to the rest of the body). This may be a mechanism by which it protects against atherosclerosis, but more studies are needed to confirm this.

The addition of Pioglitazone reduces daily insulin dosages, but study findings have not been consistent. Improvement of lipid profiles has also been weak with this combination therapy. Long-term studies are needed before any conclusions can be reached. Combination therapy should be primarily used for patients who achieve an insufficient reduction in blood sugar with insulin alone.

Pioglitazone & Rosiglitazone both belong to a class of antidiabetics called Thiazolidinediones. Rosiglitazone has been removed from the market because using this drug was associated with increased risk of cardiovascular events like heart attack and stroke. Pioglitazone can cause heart failure too, but the risk is less that that with Rosiglitazone. Both the medicines should be avoided in heart failure.

Fortunately, there are many alternatives to Pioglitazone- Metformin, Acarbose, Sitagliptin, Exenatide, Insulin or combination therapies of these medicines can be used.

Findings indicate that Pioglitazone treatment is associated with a reduced dementia risk in Diabetes mellitus patients. Prospective studies are needed to evaluate a possible neuroprotective effect in these patients in an ageing population.

Pioglitazone may be of use in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as by drugs like Clomiphene, Dexamethasone, or Metformin.

The use of Pioglitazone for plaque psoriasis treatment is controversial. Some studies revealed no effect of Pioglitazone 30 mg daily neither on the clinical response of moderate-to-severe psoriasis whereas others demonstrate that it could be considered as an efficacious and safe agent for the treatment of plaque psoriasis.

In a research study in a small number of autistic children, daily treatment with 30 or 60 mg Pioglitazone for 3–4 months induced apparent clinical improvement. Pioglitazone should be considered for further testing of therapeutic potential in autistic patients but as of now, autism is not an approved indication for Pioglitazone use.

Pioglitazone, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study.

A recent study shows that although Pioglitazone causes a significant decrease in blood sugar, HbA1C and lipid levels, it is associated with weight gain, which would limit its utility. It has not been shown to cause weight loss.

Pioglitazone has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.

Pioglitazone reduces recurrent stroke and major vascular events in stroke patients with insulin resistance, prediabetes, and diabetes mellitus. However, its use as a preventive therapy requires more research.

Metformin can lower blood sugar level (hypoglycemia). It happens more often if you delay or miss your food, do more than your routine exercise, drink alcohol or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important and be cautious of symptoms of hypoglycemia and always keep glucose tablets, honey or fruit juice with you.

Metformin is generally a safe and well-tolerated drug even on long-term use. However, its long-term use can cause vitamin B12 deficiency leading to anemia and peripheral neuropathy (nerve damage). so, it should be taken only at prescribed doses for the duration as advised by the doctor.

No, Metformin is not a sulfonylurea. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.

No, Metformin is not a steroid. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modifications in diet and exercise.

Metformin commonly causes stomach upset like bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea. To avoid these side effects, it is advised to be taken after meals, preferably started at a low dose and then increased slowly over weeks, or by using slow-release tablets.

Metformin is seen to be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). One of the underlying cause of NAFLD is insulin resistance. Metformin improves insulin resistance and liver enzymes in these patients. It is not seen to benefit patients of alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.

Coenzyme Q10 is an antioxidant that helps in energy production and is found in heart, liver, kidney, and pancreas (which produces insulin). It can repair the damage caused to these organs by free radicals. Low levels of CoQ10 are seen in patients with diabetes. So, some researchers suggest it be given from outside. It can be taken with Metformin as no drug-drug interactions or harmful effects have been seen between the two.

Yes, Metformin does improve menstrual cycle (periods) regularity in women with polycystic ovarian syndrome (PCOS). It is associated with insulin resistance, decreased ovulation, and high androgen levels which cause menstrual irregularities like delayed periods and scanty bleeding. Metformin helps in regularizing menstrual cycles by improving insulin sensitivity, ovulation rate, and decreasing androgen levels.

Yes, Metformin can be taken with atorvastatin. There are no reported harmful effects when they are used together. Rather some studies suggest beneficial effects in diabetics as they may prevent a very high increase in blood glucose after food, decrease some inflammation markers and protect the patients from liver injury.

Metformin can be taken with phentermine. These are sometimes given together in obese patients who are also diabetic and are taking Metformin along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, phentermine can decrease the effect of Metformin leading to very high blood glucose levels. So, a dose adjustment of Metformin may be needed.

Metformin can be taken with levothyroxine but the dose of Metformin may need to be adjusted. Levothyroxine can decrease the effect of Metformin leading to very high blood glucose levels. These are used together in patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS).

Metformin can be taken with prednisolone but the dose of Metformin may need to be adjusted. Prednisolone can decrease the effect of Metformin leading to very high blood glucose levels. Continuous use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Metformin is recommended in these patients.

Metformin can be taken with metoprolol. There are no reported drug interactions or harmful effects in humans when they are used together. However, some animal studies suggest that metoprolol can decrease the blood levels of Metformin and on long-term use can increase lactic acid and uric acid levels.

Metformin is not indicated for clearing acne due to just any condition. It only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.

No, hair loss has not been reported with Metformin. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.

No, weight gain has not been reported with Metformin. Rather it helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.

Metformin is not known to cause constipation. Some common side effects associated with the use of Metformin includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.

Metformin is a safe and well-tolerated drug even on long-term use when taken strictly as advised by the doctor. However, there are some very common side effects like nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite you may experience even at therapeutic doses.

Metformin is not known to increase blood pressure. Some common side effects associated with the use of Metformin includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.

No, Metformin is not an insulin. Metformin is an oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better. Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.

No, Metformin is not a banned drug. It is a prescription medicine and is available when prescribed by registered medical practitioner.

No, Metformin is not a birth control pill. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.

No, Metformin is not a statin. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.

Both Metformin and saxagliptin are anti diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.

Metformin is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.

Lactic acidosis is a rare, but serious complication associated with the use of Metformin. Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor.

Metformin is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Metformin.

No, Metformin does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metformin include anxiety and depression.

Usually, Metformin is not associated with back pain. However, it can be a presentation of stomach upset, a common side effect caused by Metformin which includes bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Metformin.

Yes, Metformin causes vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.

Yes, Metformin is seen to be useful in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist. Metformin is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight.

Both Metformin and glimepiride are anti diabetic drugs and can be used together. They work by different mechanisms and can control the blood sugar levels in a much better way when used together as compared to either drug taken alone. However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.

Yes, Metformin can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.

Metformin can be taken with ranitidine. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Metformin from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well and the dose of Metformin may need adjustment.

Both Metformin and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.

Yes, some research studies have shown that Metformin can decrease the multiplication and growth of hepatitis B virus when given along with other antiviral drugs. However, this is indication is still under research and not yet approved.

Metformin should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Metformin along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Metformin. However, do not stop taking any medicine without talking to your doctor.

Metformin can cause sleepiness which could be an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is a serious condition caused by Metformin seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor.

Use of Metformin is not associated with joint pain. However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is also associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.

Metformin may be of help in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines. Metformin improves insulin sensitivity and prevents weight gain, both of these factors are affected by the use of antipsychotics.

Both Metformin and gliclazide are antidiabetic drugs but work in different ways. Metformin works by decreasing glucose production from liver and decreasing glucose absorption from the gut and increasing insulin sensitivity. Gliclazide works by increasing insulin release from the pancreas. Both control blood sugar levels effectively but Metformin causes more of stomach upset, like nausea, vomiting, diarrhea and bloating while gliclazide causes low blood sugar levels and weight gain.

Metformin has shown promising results in some animal research studies in the treatment of fragile X syndrome. It may help in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients. But these results are very preliminary and it is still not approved for the treatment of fragile X syndrome.

Metformin and liraglutide are antidiabetic drugs and both control blood sugar levels effectively. Metformin is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. While liraglutide is an injectable and it increases insulin release from the pancreas. Both cause stomach upset, like nausea, vomiting, diarrhea and bloating while liraglutide also increases the risk of pancreatitis.

No, Metformin does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metformin include anxiety and depression.

Yes, sweating is one of the known side effects of Metformin. The exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your doctor as your dose of Metformin may need to be adjusted.

Metformin can be taken with clomiphene citrate. They are advised together in patients with infertility along with polycystic ovarian syndrome (PCOS). Clinical studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.

Metformin is seen to be useful in the treatment and prevention of cancers especially breast cancer in research studies. As high insulin levels are known to increase the risk of cancer, Metformin decreases cancer cell growth by decreasing insulin and blood glucose levels. However, its use in treating breast cancer is not yet approved.

No, Metformin is not associated with an increased risk of Helicobacter pylori infection. Diabetes itself increases the risk of H.pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Metformin.

Metformin may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.

Metformin is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Metformin makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metformin.

Yes, Metformin can be taken with teneligliptin. It is a good add-on treatment if the blood sugars are very high even after taking Metformin. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.