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Venlafaxine(37.5 mg)


Venlafaxine(37.5 mg)


Venlafaxine is used to treat major depressive episodes and to prevent repeated occurrence of such episodes.

How it works

Venlafaxine belongs to a group of medicines called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing signal transmission (neurotransmitter activity) in the central nervous system of brain.

Common side effects

Yawning, Impotence, Decreased libido, Loss of appetite, Headache, Insomnia, Increased blood pressure, Nervousness, Nightmare, Weight loss, Chills, Sedation, Increased cholesterol level in blood, Dilatation of the pupil of the eye, Ejaculation disorder, Tremor, Abnormal sensation in skin, Dry mouth, Anorgasmia (decreased orgasm), Confusion, Dizziness, Vomiting, Vasodilation, Increased sweating, Impaired urination, Irregular menstrual cycle, Abnormal visual accomodation, Nausea, Constipation, Weakness, Visual impairment, Depersonalisation (feelings of being outside the body), Increased muscle contractions, Palpitations, Abnormal urination during the day, Suicidal thoughts


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Expert advice

  • Seek immediate medical attention if you develop any suicidal tendency at initial stages of recovery.
  • Do not use in children and adolescents below 18 years of age.
  • Taking venlafaxine may increase risk of dilatation of pupil of eye (mydriasis). Seek medical advice from your doctor.
  • Stop taking venlafaxine if you develop fits.
  • Care should be taken if you are an elderly patient, taking diuretics, and if you have volume-depletion, because there may be a greater risk of hyponatremia (low sodium in blood).
  • Use with caution if you are prone to bleeding, if you are taking anticoagulants and platelet inhibitors, or if you have heart disease, high blood pressure, high cholesterol, liver disease, kidney disease, narrow-angle glaucoma.
  • If you are on antidiabetic therapy you may advised to adjust the dose of the medication. 

Frequently asked questions


Q. Is venlafaxine safe during pregnancy?
Venlafaxine should only be used if the potential benefits justify the potential risk to the baby. Please follow your doctor's advice regarding its use.

Q. Is it safe to use venlafaxine safe during breastfeeding?
Venlafaxine should be given only if the potential benefit justifies the potential risk to the infant. Please follow your doctor's advice regarding its use.

Q. Is venlafaxine an SSRI/MAOI/narcotic/ antipsychotic/ sedating/benzodiazepine?
Venlafaxine is an antidepressant drug. In animal studies, it is found to have serotonin reuptake inhibitor (SSRI) activity. It is not a narcotic/ antipsychotic/ sedating/ benzodiazepine.

Q. Is venlafaxine safe?
Venlafaxine is safe if used at prescribed dose and duration as advised by your doctor for a particular disease condition.

Q. Is venlafaxine the same as Effexor?
Yes, Effexor is a brand name of drug containing venlafaxine.

Q. Can I take Effexor/venlafaxine forever?
No, patient should take Effexor/venlafaxine for prescribed duration as advised by your doctor.

Q. Can I take Effexor (venlafaxine) with Mucinex (guaifenesin)?
Taking Effexor (venlafaxine) with Mucinex (guaifenesin) does not cause any harmful effects. Please follow your doctor's advice regarding its use.

Q. Can I take venlafaxine or Effexor with Xanax (alprazolam)/diazepam/ mirtazapine/ tramadol/ hydrocodone/ Wellbutrin (bupropion)?
Taking Effexor (venlafaxine) with Xanax (alprazolam)/ diazepam/ mirtazapine/ tramadol/ hydrocodone/ Wellbutrin (bupropion) may cause harmful effects such as fits, dizziness, and serotonin syndrome. Please follow your doctor's advice regarding its use.

Q. Can I take venlafaxine with alcohol?
No, alcohol consumption should be avoided when taking venlafaxine treatment.

Q. Can I take Effexor without food?
Effexor (venlafaxine) should be taken with food.

Q. Does venlafaxine contain MAOI?
No, it does not contain monoamine oxidase inhibitors (MAOIs).

Q. Does venlafaxine affect birth control/ affect libido/ cause memory loss?
These side effects are observed with venlafaxine use. Consult your doctor if you experience one or more such symptoms.

Q. Does venlafaxine help with anxiety/ pain/to lose weight?
Venlafaxine is used to treat major depressive episodes and to prevent recurrence of such episodes. Its use in anxiety, pain and to lose weight is not established. Please follow doctor’s advice regarding its use.


Content on this page was last updated on 21 April, 2014, by Dr. Varun Gupta (MD Pharmacology)