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Composition FOR TVAPTAN


food interaction for TVAPTAN

alcohol interaction for TVAPTAN

pregnancy interaction for TVAPTAN

lactation interaction for TVAPTAN

It can be taken with or without food, but it is better to take Tvaptan 30 mg tablet at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Tvaptan 30 mg tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.




Tvaptan 30 mg tablet is used in the treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH)

How it works

Tvaptan 30 mg tablet works by increasing the amount of water released from the body by increasing the amount of urine. Removing fluid from the body helps to maintains the level of sodium in the blood.

Common side effects

Headache, Dizziness, Frequent urge to urinate, Nocturia (increased urge to urinate during the night), Dry mouth, Fatigue, Polyuria, Diarrhoea, Increased thirst


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Expert advice FOR TVAPTAN

  • Do not eat grapefruit or drink grapefruit juice while taking this medication. If you stop taking tolvaptan for any length of time, do not start taking it again at home. You will need to be in a hospital under observation any time you start or restart treatment with tolvaptan.
  • Consult your doctor immediately if you have any of these signs: problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, mood changes, and seizure (convulsions).
Do not start or continue tolvaptan:
  • if you are allergic to tolvaptan, or to any of the other ingredients of this medicine.
  • if your kidneys do not work (no urine production).
  • if you have a condition which increases the salt in your blood (“hypernatraemia”).
  • if you have a condition which is associated with a very low blood volume.
  • if you do not realise when you are thirsty.
  • if you are pregnant or breastfeeding.
Talk with your doctor before taking tolvaptan:
  • if you cannot drink enough water or if you are fluid restricted.
  • if you have difficulties in urination or have an enlarged prostate.
  • if you suffer from liver disease.
  • if you have diabetes.

Frequently asked questions FOR TVAPTAN



Is tolvaptan / samsca a diuretic?
Samscais brand name of tolvaptan and it is a diuretic


Does tolvaptan work in pkd-Polycystic kidney disease?
Yes. Recently it is found that tolvaptan can slow the development and progression of polycystic kidney disease in animal models.


Content on this page was last updated on 03 February, 2017, by Dr. Varun Gupta (MD Pharmacology)