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10 Jul 2019 | 02:54 PM (IST)
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Trasturel 440 mg Injection


Overview

Uses of Trasturel Injection

Trasturel Injection side effects

Common
  • Nausea
  • Headache
  • Rash
  • Insomnia (difficulty in sleeping)
  • Infection
  • Upper respiratory tract infection
  • Fatigue
  • Fever
  • Anemia (low number of red blood cells)
  • Chills
  • Diarrhea
  • Cough
  • Weight loss
  • Taste change
  • Mucosal inflammation
  • Stomatitis (Inflammation of the mouth)
  • Heart failure
  • Decreased blood cells (red cells, white cells, and platelets)
  • Common cold

How to use Trasturel Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Trasturel Injection works

Trasturel 440 mg Injection is a monoclonal antibody specifically designed to target HER2 receptors on breast cancer and stomach cancer cells. It flags the cancer cells for destruction by the body's immune system.

Trasturel Injection related warnings

Alcohol
Interaction with alcohol is unknown. Please consult your doctor.
Pregnancy
WEIGH RISKS VS BENEFITS
Trasturel 440 mg Injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Lactation
CAUTION
Trasturel 440 mg Injection is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Driving
It is not known whether Trasturel 440 mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
Trasturel 440 mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Trasturel 440 mg Injection may not be needed in these patients. Please consult your doctor.
Liver
There is limited information available on the use of Trasturel 440 mg Injection in patients with liver disease. Please consult your doctor.

What if you miss a dose of Trasturel Injection?

If you miss a dose of Trasturel 440 mg Injection, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Trasturel 440 mg Injection
₹58633.92/Injection
save 4%
₹59981.6/ml of Injection
save 2%
Hertraz 440mg Injection
Mylan Pharmaceuticals Pvt Ltd
₹57500/Injection
save 6%
₹75000/Injection
23% costlier
Herclon 440mg Injection
Roche Products India Pvt Ltd
₹66156.25/Injection
8% costlier

Expert Advice

  • It is given as an injection into your vein or under the skin, usually over 1 hour.
  • Use effective contraception method to prevent pregnancy while taking this medicine and for 7 months after you stop the treatment. 
  • Your doctor will monitor your heart regularly while taking this medicine. Inform your doctor if you notice symptoms such as breathlessness, cough, shivering, swelling of legs and arm.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. 

Patient Concerns

Questions Related to Trasturel

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Any medicine to treat stage 4 breast cancer and strengthen immunity
Dr. Saurav Arora
Homeopathy
Dear mam you can safely take homeopathic treatment in your case, but as your case is chronic the treatment should be under monitoring of a physician
She has breast cancer at 4 sta
Dr. Rohan Khandelwal
Cancer Specialist
Dear PATIENT 4 Breast Cancer means that the cancer has spread to other parts of the body. The management of such cancers depends on the site where the cancer has spread and on the receptor status of the breast cancer. If you can share the details with me, I will be happy to let you know the potential management
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Do you have any questions related to Trasturel 440 mg Injection?

User Feedback


FAQs

Q. What are the serious side effects of Trasturel?

There are various side effects related to Trasturel such as sore throat, fever, chills, excessive tiredness, pale skin, nosebleeds, and other unusual bruising or bleeding. One can also experience stomach pain, seizures, hallucinations, muscle cramps, and spasms. Along with that, nausea or vomiting, loss of appetite, fatigue, rapid heart beat, discoloration of urine; decreased amount of urine, difficulty in urinating, pain when urinating, and other signs of infection can also be observed with the use of Trasturel. You should call your doctor immediately if you notice any such symptoms.

Q. How long after Trasturel therapy can I get pregnant?

Women of child-bearing age should use effective contraception during Trasturel therapy and for 7 months after completing the treatment. You can plan your pregnancy after 7 months of treatment with Trasturel.

Q. How long should Trasturel be taken?

Patients with early breast cancer should take Trasturel for 1 year or until disease recurs, whichever occurs first. It is not advised to extend the treatment beyond 1 year in patients of early breast cancer.

Q. Is fasting required before administering Trasturel?

No, fasting is not required before administering Trasturel. It should be given under the guidance of a doctor who is experienced in giving cancer chemotherapy and should be given only by a healthcare professional.

Q. How is Trasturel given, intravenously or intramuscularly?

There are 2 different formulations available for administration of Trasturel, one is given as an infusion into a vein (intravenous infusion) and the other is given as an injection under the skin (subcutaneous injection). It is important to check the product labels to ensure that the correct formulation is being given as prescribed. Trasturel intravenous formulation is not for subcutaneous use and should be given as an intravenous infusion only. Your doctor may consider switching your Trasturel intravenous treatment to Trasturel subcutaneous treatment (and vice versa) if considered appropriate for you.

Q. Can Trasturel be given to HER2 negative cancer patients?

No, Trasturel cannot be given in patients with HER2 negative cancer cells. Trasturel belongs to class of monoclonal antibody. It binds selectively to a protein called human epidermal growth factor receptor 2 (HER2). HER2 is found, in large amounts, on the surface of some cancer cells. When Trasturel binds to HER2, it stops the growth and spread of the cancer cells. Therefore, it is only effective in HER2 positive patients (in which HER2 is present) and will not be beneficial for HER2 negative patients (in which HER2 is not present).

Q. Why has my doctor advised for investigations of heart?

Trasturel when used with anthracycline class of anti-cancer medicines (eg doxorubicin) may adversely affect your heart. Hence, your doctor needs to check the health of your heart initially before starting treatment and during treatment.

Q. How frequently heart investigations are required?

Heart investigations should be performed at the starting of the treatment. It should be repeated every 3 months during treatment and every 6 months after the discontinuation of treatment until 24 months from the last administration of Trasturel. Those patients who already have heart-related problems will require investigations every 12 weeks.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 978.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1390-91.
  4. Trastuzumab. South San Francisco, California: Genentech, Inc.; 1998 [revised Oct. 2010]. [Accessed 27 Mar. 2019] (online) Available from:External Link
  5. U.S. National Library of Medicine. Trastuzumab. [Accessed 27 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Dhirubhai Ambani Life Sciences Centre, R-282, TTC Area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai 400 701
Best Price
₹48905.7
MRP61132.12  Get 20% OFF
1 Injection in 1 vial
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