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Composition for TIZAFLEX

Nimesulide(100 mg),Tizanidine(2 mg)

food interaction for TIZAFLEX

alcohol interaction for TIZAFLEX

pregnancy interaction for TIZAFLEX

lactation interaction for TIZAFLEX

There is no data available. Please consult doctor before consuming the drug.
Tizaflex 100mg/2mg tablet may cause excessive drowsiness and calmness with alcohol.
Tizaflex 100mg/2mg tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Tizaflex 100mg/2mg tablet is probably unsafe to use during breastfeeding. Please consult your doctor.


Nimesulide(100 mg)


Nimesulide is used to treat acute pain, osteoarthritis (pain and swelling of joints due to degeneration) and pain during periods.

How it works

Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

Common side effects

Nausea, Rash, Abnormal blood cell count, Anemia, Constipation, Diarrhoea, Dizziness, Shortness of breath, Gastritis, Hypersensitivity reaction, Increased blood pressure, Swelling, Increased sweating, Itching, Liver enzyme increased, Vomiting
Tizanidine(2 mg)


Tizanidine is used to treat rigidity of muscles (spasticity) associated with various brain and nerve disorders (like cerebral palsy, meningitis, multiple sclerosis, motor neuron disease, cerebrovascular accidents), diseases of the spinal cord, other injuries which affect the brain and other parts of nervous system in adults.

How it works

Tizanidine belongs to group of medicines called centrally acting muscle relaxants. It acts by blocking the nerve impulses which excites the muscles reducing their tone. As a result, the muscle relaxes and there is reduction of pain and spasms.

Common side effects

Vomiting, Nausea, Abdominal pain, Skin rash, Allergic reaction, Altered vision, Back pain, Bruise, Bleeding, Dizziness, Depression, Drowsiness, Nervousness, Dry mouth, Fatigue, Heartburn, Altered heart rate, Bradycardia, Increased sweating, Influenza like symptoms, Loss of appetite, Muscle cramp, Tingling sensation, Auditory hallucination, Visual hallucination, Weakness, Yellow discoloration of skin, Yellow discoloration of eye, Constipation, Diarrhoea


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Expert advice for TIZAFLEX

Do not take this medicine:
  • if you are allergic to Nimesulide, or any of the other ingredients of this medicine.
  • if you have or had gastric ulceration/bleeding in the past.
Do not consume more than one pain-relieving medication at a time.Caution is advised with the use of Nimesulide if you have bleeding disorder. Nimesulide may cause infertility in women, and should not be consumed by women planning to become pregnant This medicine should not be given to a child under 12 years of age.
Treatment with Nimesulide should be of short duration and discontinued if it is of no help.

Frequently asked questions for TIZAFLEX


Q. Is Nimesulide an antibiotic?
No, Nimesulide is non-steroidal anti-inflammatory drug (NSAIDs; pain-relieving drug) which relieves acute pain in conditions like joint pain and period pain. However, it may be used with antibiotics to relieve pain associated with certain infections.
Q. Can I take Nimesulide with paracetamol or ibuprofen?
Nimesulide, paracetamol and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs; pain-relieving drugs). Taking two NSAID drugs together is not advisable as it may increase the potential for gastric ulceration and bleeding.
Q. Does Nimesulide contain aspirin or sulphur?
No. Nimesulide is a non-steroidal anti-inflammatory drug (NSAIDs; pain-relieving drug) doesn’t contain aspirin or sulphur.
Q. Is Nimesulide safe?
Nimesulide is safe at prescribed dose and duration as advised by your doctor.


Q. Does tizanidine contain sulfa or asprin?
Tizanidine does not contain sulfa and aspirin.
Q. Is tizanidine an opiate, NSAID, blood thinner, controlled substance, or muscle relaxer?
Tizanidine is not an opiate, NSAID, blood thinner or a controlled substance. It is a muscle relaxant.
Q. Is tizanidine like valium?
Valium is a brand name for drug diazepam. It is also used as a muscle relaxant, but both have different functions. Please consult your doctor before taking the drug.
Q. Is tizanidine stronger than Flexeril?
Flexeril is a brand name for drug cyclobenzaprine, which is also used as a muscle relaxant. Effect of the drug may vary upon individual response. Please consult your doctor before taking the drug.
Q. Is tizanidine water soluble?
Tizanidine is a lipid-soluble drug; it is only slightly soluble in water and methanol.
Q. Is tizanidine gluten free?
Tizanidine is gluten free. However, please refer to package insert of the prescribed brand before use.
Q. Can I take tizanidine or Zanaflex for menstrual cramps, headaches, or anxiety?
No, you cannot take tizanidine or Zanaflex (which contains tizanidine) for menstrual cramps, headaches, or anxiety. Please consult your doctor before taking the drug.
Q. Does tizanidine cause weight loss or keep you awake (insomnia)?
You may experience insomnia or weight loss with the use of tizanidine. Few people may experience excessive sleepiness. If you experience such side effects, consult your doctor.
Q. Can I take tizanidine with Aleve (naproxen), Ambien (zolpidem), Norco (acetaminophen and hydrocodone), Tylenol (paracetamol), Valium (diazepam), or Xanax (alprazolam)?
You may take Aleve and Tylenol with tizanidine, but Ambien, Norco, Valium, and Xanax should not be given with tizanidine. Consult your doctor before simultaneous use.
Q. Can I take tizanidine with prednisone, ibuprofen, tramadol, or oxycodone?
Tizanidine may be taken with prednisone or ibuprofen, but tramadol or oxycodone with tizanidine may increase their side effects. Consult your doctor before simultaneous use.
Q. Does tizanidine show on a drug test?
No, tizanidine does not show on a drug test. Only narcotic drugs show up on a drug test.


Content on this page was last updated on 03 January, 2014, by Dr. Varun Gupta (MD Pharmacology)