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Composition for TIXYLIX

Promethazine(1.5 mg),Pholcodine(1.5 mg)

food interaction for TIXYLIX

alcohol interaction for TIXYLIX

pregnancy interaction for TIXYLIX

lactation interaction for TIXYLIX

There is no data available. Please consult doctor before consuming the drug.
Tixylix new syrup may cause excessive drowsiness and calmness with alcohol.
Tixylix new syrup may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Promethazine(1.5 mg)


Promethazine is used for treatment of allergies to the upper respiratory tract and skin including symptoms of sneezing, runny and itchy nose and eye irritation and red, raised, itchy skin rash. It is also used to prevent and control nausea, vomiting and pain which may occur after surgery; to prevent motion sickness. It also used as a short-term sedative.

How it works

Promethazine belongs to the group of medicines called antihistamines. It also has additional anti-emetic, central sedative and anti-cholinergic properties. It acts by blocking a natural substance called histamine that your body produces during an allergic reaction.

Common side effects

Nightmare, Pale red skin, Itchy rash, Rash, Abdominal cramp, Abnormal liver function tests, Altered heart rate, Blurred vision, Confusion, Decreased blood pressure, Diarrhoea, Disorientation (alteration of mental status), Dizziness, Drowsiness, Dry mouth, Gastric irritation, Headache, Hypersensitivity reaction, Inability to empty the urinary bladder, Itching, Loss of appetite, Muscle cramp, Nausea, Restlessness, Vomiting, Fatigue
Pholcodine(1.5 mg)


Pholcodine is used to suppress cough for temporary relief from dry cough (cough without any mucus or phlegm production).

How it works

Pholcodine belongs to class of drugs called cough suppressants. It works by suppressing the center for cough reflex in the brain (centrally acting) thereby providing relief.

Common side effects

Nausea, Allergic reaction, Chest congestion, Confusion, Constipation, Dizziness, Drowsiness, Shortness of breath, Excitement, Rash, Vomiting

Common Dosage

Patients taking this medicines

  • 53%
    Three Times A Day
  • 32%
    Two Times A Day
  • 16%
    One Time A Day


2 Substitutes
Sorted By

Top General Physicians

  • Dr. M. K. Singh
    MBBS, MD
  • Dr. Prabhat Kumar Jha
    MBBS, MD
  • Dr. Sushila Kataria
    MBBS, MD, Diploma
  • Dr. R. S. Rawat
    MBBS, MD
  • Dr. R. R. Dutta
    MBBS, MD

Expert advice for TIXYLIX

  • Do not start or continue the promethazine tablets if you are allergic (hypersensitive) to promethazine or any of the other ingredients of promethazine tablet.
  • Do not drive or operate machinery after taking promethazine if you feel drowsy.
  • Do not use promethazine for more than 7 days without doctor’s advice.
  • Do not use in patients in coma or suffering from depression.
  • Doctor’s advice should be considered in case of following disease conditions: severe coronary artery disease, narrow angle glaucoma, epilepsy (fits) or liver or kidney problem, block in the junction of stomach and intestine (pyloro-duodenal obstruction) or in the bladder neck.

Frequently asked questions for TIXYLIX


Q. Is promethazine or Promethazine DM syrup a narcotic/opiate/pain killer?
Promethazine is antihistaminic drug and not a narcotic/opiate/pain killer. Patient should follow the advice of doctor regarding its use.
Q. Is promethazine over the counter?
No, it is available with doctor’s prescription only.
Q. Can I take promethazine for a hangover/sore throat/ nausea/stomach flu/cramps/toothache/ headache/ cough/pain?
Promethazine is used for treatment of symptoms of allergies, but not used for  hangover, sore throat, stomach flu, cramps, toothache, headache and cough. Patient should follow the advice of doctor regarding its use.
Q. Can I take promethazine with Nyquil/ codeine and ibuprofen/ Tylenol/ oxycodone/ Benadryl/ Dayquil/ Zofran/codeine and Nyquil/Xanax?
Yes, but taking other medicines may alter the effects of promethazine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.
Q. Does promethazine/Promethazine VC have codeine in it?
No, it does not contain codeine in it.
Q. Does promethazine or Promethazine DM make you sleepy/ get you high/make you tired?
Promethazine may cause these side effects which are not serious. However, always consult your doctor if you experience any of these side effects.


Q. Is pholcodine the same as codeine?
No. Pholcodine and codeine are two different drugs that have similar uses (treatment of dry cough) and mechanism of action. Pholcodine has a lower tendency for drug dependence (addiction) and may be preferred in certain cases over codeine. 

Does pholcodine make you drowsy?
Yes. Drowsiness is a side effect of pholcodine use.


Content on this page was last updated on 10 September, 2016, by Dr. Varun Gupta (MD Pharmacology)