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Composition for SPANDRIL

Dicyclomine(20 mg),Mefenamic Acid(250 mg)

food interaction for SPANDRIL

alcohol interaction for SPANDRIL

pregnancy interaction for SPANDRIL

lactation interaction for SPANDRIL

It is better to take Spandril 20mg/250mg tablet with food.
Taking Mefenamic acid with alcohol increases the risk of stomach bleeding.
Spandril 20mg/250mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Spandril 20mg/250mg tablet is probably safe to use during breastfeeding. Please consult your doctor.


Dicyclomine(20 mg)


Dicyclomine is used to treat periodic spasms and pain in abdomen and stomach, intestinal cramps, irritable bowel syndrome (disorder of the intestines that leads to cramps in the abdomen, gas, bloating and changes in bowel habits) and inability to control urine (urinary incontinence).

How it works

Dicyclomine belongs to antispasmodic and anticholinergic (antimuscarinic) class of medicines that act by relieving the smooth muscle tightening (contraction) of the gastrointestinal tract via dual action: (i) by a specific action (anticholinergic), which reduces muscle contractions and (ii) by a direct effect on muscles of the stomach and intestine (musculotropic) leading to muscle relaxations, and decrease in contraction and pain.

Common side effects

Flatulence, Abdominal bloating, Blurred vision, Gastrointestinal discomfort, Constipation, Dizziness, Drowsiness, Weakness, Dry mouth, Difficulty in urination, Headache, Loss of appetite, Stomach pain, Vomiting
Mefenamic Acid(250 mg)


It is used to treat joint pain (arthritis), headache (migraine), dental pain and pain during periods (dysmenorrhoea). It is also used to reduce fever in various infections.

How it works

Mefenamic acid belongs to the class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance (prostaglandins) that causes pain, fever, and inflammation.

Common side effects

Drowsiness, Diarrhoea, Abdominal pain, Dizziness, Headache, Heartburn, Nausea, Stomach upset, Vomiting


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Expert advice for SPANDRIL

  • This medication may impair your thinking or alertness. Be careful if you drive or do anything that requires you to be alert.
  • Avoid becoming overheated or dehydrated during exercise and in hot weather. Dicyclomine can decrease your sweating, which can lead to heat stroke in a hot environment.
  • Avoid taking alcohol as it can increase certain side effects of dicyclomine.
  • Stop using dicyclomine and call your doctor right away if you have serious side effects such as confusion, hallucinations, unusual thoughts or behavior, fast or uneven heart rate, or if you urinate less than usual or not at all.

Frequently asked questions for SPANDRIL


Q. Is Dicyclomine safe?
Dicyclomine is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is Dicyclomine gluten free?
Dicyclomine active drug does not contain gluten. Read the label instruction of the brands your doctor prescribes you, for gluten content.
Q. Is Dicyclomine an over-the-counter medicine?
Dicyclomine is available over-the-counter. However, always consult your doctor before taking dicyclomine for your disease.
Q. Does dicyclomine help nausea?
Dicyclomine is not known to relieve nausea. Nausea is a common side effect of dicyclomine.
Q. Does dicyclomine help constipation or trigger constipation?
Dicyclomine may cause constipation.
Q. Is dicyclomine an opiate/steroid/antacid/NSAID/benzodiazepine?
Dicyclomine is not an opiate, steroid, or an antacid. It is neither a NSAID not a benzodiazepine.
Q. Is dicyclomine a muscle relaxer?
Yes, dicyclomine is a smooth muscle relaxant. It has a direct effect on muscles of the stomach and intestine. It does not relax the skeletal/voluntary muscles.
Q. Can I take dicyclomine for diarrhea?
Dicyclomine has no known effects in treating diarrhea.
Q. Can I take dicyclomine for menstrual cramps?
Dicyclomine mainly acts on the smooth muscles of the intestine. Hence, it is used to relieve cramps or spasms of the stomach and intestines (gut). It is not known whether it can be used for menstrual cramps.
Q. Does dicyclomine cause constipation?
Dicyclomine may cause constipation.
Q. Does dicyclomine make you drowsy?
Dicyclomine may cause drowsiness and make you feel sleepy.
Q. Does dicyclomine cause hair loss?
Dicyclomine does not have hair loss as a known side-effect.
Q. Can I take dicyclomine with Advil (ibuprofen)/ amoxicillin/ Pepto (bismuth subsalicylate)/ tramadol/ Vicodin (acetaminophen and hydrocodone)/ oxycodone/ Tylenol (paracetamol)?
There are no known serious drug interactions between dicyclomine and Advil (ibuprofen)/ amoxicillin/ Pepto (bismuth subsalicylate)/ Tramadol/ Vicodin (acetaminophen and hydrocodone)/ oxycodone/ Tylenol (paracetamol). Dicyclomine is often available in combination with pain killers like paracetamol Consult your doctor about all medications currently taken before starting and while on dicyclomine.

Mefenamic Acid

Q. Is mefenamic acid an antibiotic/ contain codeine?
No. Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat mild to moderate pain conditions and fever. It not an antibiotic and does not contain codeine.
Q. Is mefenamic acid a painkiller?
Yes. Mefenamic acid is mild to moderate painkiller drug.
Q. Is mefenamic acid safe?
Mefenamic acid is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is mefenamic acid good for toothache/ for back pain/ headache?
Yes, mefenamic acid can be used to relieve dental pain, back pain and headache.
Q. Does mefenamic acid stop periods/ stop bleeding?
Mefenamic acid is used for relieving pain that happens before or during a menstrual period. It does not stop periods or bleeding. Always consult your doctor regarding its use.
Q. Can I take mefenamic acid with naproxen/ paracetamol/ ibuprofen/ metronidazole/ with tramadol/ with tranexamic acid/ with sertraline/ amoxicillin?
Mefenamic acid may interact with the drugs mentioned above. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Q. Does mefenamic acid make you drowsy?
Mefenamic acid has a rare side effect of causing drowsiness. Always consult your doctor, if you experience such side effects.


Content on this page was last updated on 04 January, 2015, by Dr. Varun Gupta (MD Pharmacology)