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Composition for SIBOLONE

Tibolone(12.5 mg)

food interaction for SIBOLONE

alcohol interaction for SIBOLONE

pregnancy interaction for SIBOLONE

lactation interaction for SIBOLONE

It can be taken with or without food, but it is better to take Sibolone 12.5 mg tablet at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Sibolone 12.5 mg tablet is highly unsafe in women who are or may become pregnant.
Human and animal studies have shown significant adverse effects on the fetus and should not be given under any circumstances. Please consult your doctor.
Sibolone 12.5 mg tablet is probably unsafe to use during breastfeeding. Please consult your doctor.


Tibolone(12.5 mg)


Sibolone 12.5 mg tablet is used in the treatment of estrogen deficiency symptoms in postmenopausal women. It is also used in the prevention of osteoporosis (thinning and weakening of the bone) in postmenopausal women or in women whose ovaries have been surgically removed or have stopped functioning, who are at high risk of future fractures who cannot take other medicinal products.

How it works

Sibolone 12.5 mg tablet belongs to class of medicines called synthetic steroids. It substitutes estrogen whose production is stopped in postmenopausal period. Replacement of estrogen alleviates menopausal symptoms, and also prevents bone loss following menopause or ovarian removal.

Common side effects

Painful nipples or breasts, Abdominal pain lower, Acne, Unusual hair growth, Breast pain, Cervical thickening, Fungal infection, Irritation, Itching, Limb swelling, Stomach upset, Vaginal bleeding, Vaginal discharge, Vaginal spotting, Vaginal infection, Weight gain


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Expert advice for SIBOLONE

  • You should undergo regular breast screening and cervical smear tests while on tibolone therapy.
  • Ensure that you regularly check your breasts for any changes such as dimpling of the skin, changes in the nipple, or formation of any lumps.
  • Take precaution to not take tibolone until 12 months after your last natural period, if you have undergone menopause as doing so may lead to irregular bleeding.
  • Seek immediate medical attention if you notice any signs of liver disease such as yellowing of your skin or the whites of your eyes (jaundice) or a rise in your blood pressure (symptoms may be headache, tiredness, dizziness), migraine-like headaches, if you notice signs of a blood clot, such as painful swelling and redness of the legs, sudden chest pain, difficulty in breathing.
  • You may have irregular bleeding or drops of blood (spotting) during the first 3-6 months of taking tibolone. Seek immediate medical attention if this carries on for > 6 months or starts after 6 months or continues even after stopping the medicine.
  • Exercise caution as you may be at increased risk of cancer of the lining of the womb, ovarian cancer, blood clot in a vein, heart disease or stroke.

Frequently asked questions for SIBOLONE


Q. Is tibolone safe?
Tibolone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is tibolone hormone replacement therapy (HRT)?
Yes, tibolone is a hormone replacement therapy that replaces estrogen in postmenopausal women, or women with estrogen deficiency due to ovarian failure or surgical ovarian removal.
Q. Is tibolone a steroid?
Tibolone is a synthetic steroid that has actions similar to estrogen, progesterone, and weakly similar androgens (male sex hormones) naturally present in the body.
Q. How long can I take tibolone/livial for?
Tibolone should be taken as prescribed by your doctor. Please follow your doctor’s advice regarding the same.
Q. Does tibolone cause weight gain/ hair loss/increase libido/insomnia?
Tibolone does cause weight gain. However, hair loss/increased sexual drive/ insomnia do not commonly occur with tibolone. 
Q. Does tibolone contain testosterone?
No, tibolone does not contain testosterone.
Q. Does tibolone stop periods?
Tibolone is used in postmenopausal women with at least 12 months (1 year) since their last natural period. It has no indication for use in women who are menstruating. However, if used, it can stop and cause irregularity in periods.


Content on this page was last updated on 28 June, 2016, by Dr. Varun Gupta (MD Pharmacology)