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Composition for SEMI XILIA MP

Glimepiride(2 mg),Metformin(500 mg),Pioglitazone(7.5 mg)

food interaction for SEMI XILIA MP

alcohol interaction for SEMI XILIA MP

pregnancy interaction for SEMI XILIA MP

lactation interaction for SEMI XILIA MP

There is no data available. Please consult doctor before consuming the drug.
Taking glimepiride with alcohol may affect blood glucose levels in patients with diabetes.
Taking metformin with alcohol may cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
Semi xilia mp 2 mg/500 mg/7.5 mg tablet sr may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Glimepiride(2 mg)


Glimepiride is used to lower the blood sugar levels in type 2 diabetes mellitus when diet, physical exercise and weight reduction alone are not adequate.

How it works

Glimepiride belongs to a blood sugar lowering group of medicines called sulfonylurea. Glimepiride increases the amount of insulin released by the pancreas, and thereby decreases the blood sugar level.

Common side effects

Nausea, Diarrhoea, Bruise, Bleeding, Blood in stool, Dark colored urine, Dizziness, Sore throat, Stomach pain / epigastric pain, Yellow discoloration of skin, Yellow discoloration of eye, Weakness, Fever
Metformin(500 mg)


Metformin is an antidiabetic medicine that helps to control blood sugar in people with type 2 diabetes mellitus.

How it works

Metformin belongs to class of medications called antidiabetics.It decreases the amount of glucose absorbed from the food and the amount ofglucose made by liver. Metformin also increases the body's response to insulin(a natural substance that controls the amount of glucose in the blood).

Common side effects

Flatulence, Muscle pain, Abdominal bloating, Chest pain, Skin rash, Flushing, Abdominal pain, Nail disorder, Diarrhoea, Headache, Indigestion, Bitter taste, Constipation, Allergic reaction, Heartburn
Pioglitazone(7.5 mg)


It is used in combination with diet and exercise to lower blood glucose in adults with type 2 diabetes mellitus.

How it works

Pioglitazone belongs to class of thiazolidinedione. Pioglitazone decreases insulin resistance in the periphery and in the liver that helps the body make better use of insulin it produces and also decreases the glucose output from the liver.

Common side effects

Numbness, Abnormal liver function tests, Bladder cancer, Bone fracture, Insomnia, Nasal infection, Visual impairment, Weight gain


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Expert advice for SEMI XILIA MP

  • Take glimepiride just before or with the first main meal of the day.
  • Do not skip any meal while taking glimepiride.
  • Swallow the glimepiride tablet without crushing or chewing with at least half a glass of water.
  • Do not take glimepiride if you are allergic to  glimepiride, other sulfonylureas, sulfonamides
  • Glimepiride tablets should not be given to children and adolescents under 18 years of age.

Frequently asked questions for SEMI XILIA MP


 Q. Is glimepiride a generic drug?
Yes, glimepiride is a generic drug sold under several pharmaceutical brand names (Amaryl, Zoryl, etc.).
Q. Can I take glimepiride with metformin or insulin?
Glimepiride may be given in combination with metformin and/or insulin depending on your medical condition and as prescribed by the doctor.
Q. Does glimepiride cause fluctuations in weight,diarrhea, hair loss, erectile dysfunction, swelling, constipation?
Glimepiride is reported to cause low blood sugar level,weight gain, and swelling, but is not reported to cause diarrhea, constipation, hair loss, or erectile dysfunction.
Q. Is glimepiride a fast acting sulfa drug?
Glimepiride is a medium- to long-acting sulfonylurea drug against type 2 diabetes mellitus (action lasts for 24 hours). Its maximum effect is seen after 2-3 hours of drug intake.
Q. Is glimepiride same as glipizide, glyburide, metformin, or insulin?
They are not same. Glimepiride, glipizide and glyburide belong to the same class of drugs called sulfonylureas. Metformin belong to class called biguanides.Glimepiride causes release of insulin but it is not insulin.It should only be used if no other alternative drug is available. Please follow your doctor's advice regarding its use.


Q. Is Metformin a birth control pill/ insulin / statin/ banned drug?
Metformin (also available as glyciphage, glycomet, glycomet SR) is an antidiabetic drug used in treatment of type 2 diabetes mellitus, particularly in overweight patients, as an adjunct to the diet and exercise.
Q. Is metformin safe?
Metformin is generally safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Can I take metformin forever?
Metformin should be taken at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is metformin good for weight loss / weight loss in non-diabetics?
Metformin is used for the treatment of type 2 diabetes mellitus, particularly in overweight patients. 


Q. Does pioglitazone cause hair loss?
No, pioglitazone does not cause hair loss. However, if you experience such side effects, consult your doctor.

Q. Does pioglitazone cause bladder cancer or any other cancer?
In clinical studies, more people who took pioglitazone for more than one year developed bladder cancer as compared to those who did not take pioglitazone. It is recommended to consult your doctor about the risk of taking this medication if you have had bladder cancer in the past or have a history of passing blood in urine. No other cancer type has been linked with use of pioglitazone.

Q. Does pioglitazone cause heart failure?
Pioglitazone can cause fluid retention, which may worsen or precipitate heart failure.

Q. Is pioglitazone safe?
Pioglitazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Content on this page was last updated on 10 March, 2015, by Dr. Varun Gupta (MD Pharmacology)