Safe-T Kit
Prescription RequiredProduct introduction
Safe-T Kit is a combination of two medicines, which is used for medical abortion (terminating a pregnancy). This medicine blocks the action of progesterone, a female hormone required to maintain pregnancy and induce contractions in the uterus, which further helps in abortion.
Safe-T Kit should be taken with food or as per your doctor's advice. You must start with a dose of Mifepristone. It should be taken orally, by swallowing the tablets whole with a glass of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24- 48 hours to show its action and you might experience spotting or bleeding. After a period of 36-48 hours, you have to take Misoprostol tablet, either orally or vaginally. You are suggested to have proper rest after this dose intake as it may cause severe stomach pain or vaginal bleeding thus leading to abortion.
The most common side effects of this medicine include nausea, vomiting, diarrhea and stomach cramps. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should inform your doctor immediately include heavy vaginal bleeding or abdominal pain.
Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using an intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion.
Uses of Safe-T Tablet Combikit
Benefits of Safe-T Tablet Combikit
In Medical abortion
Safe-T Kit is used to cause an abortion during the early part of a pregnancy. It is used up to week 10 of pregnancy (up to 70 days after the first day of your last menstrual period). This medicine effectively blocks the natural female hormone, called progesterone, that is needed for your pregnancy to continue. Please use it only as advised by the doctor.
Side effects of Safe-T Tablet Combikit
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Safe-T
- Nausea
- Vomiting
- Diarrhea
- Stomach cramp
- Uterine contractions
- Menorrhagia (heavy menstrual bleeding)
How to use Safe-T Tablet Combikit
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Safe-T Kit should be taken with or after food.
How Safe-T Tablet Combikit works
Safe-T Kit is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone that is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Misoprostol increases contractions of the uterus to cause abortion.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Safe-T Kit
Pregnancy
UNSAFE
Safe-T Kit is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding
UNSAFE
Safe-T Kit is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Safe-T Kit may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Safe-T Kit in patients with kidney disease. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Safe-T Kit is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
What if you forget to take Safe-T Tablet Combikit?
If you miss a dose of Safe-T Kit, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Safe-T Kit helps terminate a pregnancy.
- Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
- It does not affect fertility. Use contraception to avoid pregnancy.
- For pregnancy termination:
- Take it no later than 63 days after the first day of your last menstrual period.
- Take Misoprostol 36 – 48 hours after taking Mifepristone.
- Rest for at least 3 hours after taking the Misoprostol.
- Take it only as prescribed by the doctor. Miscarriages, if incomplete, may result in serious medical complications leading to hospitalization, surgery and possible infertility.
- Vaginal bleeding lasting for approximately 12 days may occur after taking this medicine. Inform your doctor immediately if excessive bleeding occurs or if you suffer from severe abdominal pain.
Fact Box
Habit Forming
No
Therapeutic Class
GYNAECOLOGICAL
Patient concerns
FAQs
What is Safe-T Kit and what is it used for?
Safe-T Kit contains two medicines, Mifepristone, and Misoprostol. Safe-T Kit is used for medical termination of pregnancy. It is only used to terminate a pregnancy which should not be more than 63 days old, counting from the first day of the last menstrual period.
How and in what dose should I take Safe-T Kit?
Safe-T Kit should only be taken as per the advice of the doctor. The course is started with Mifepristone. Misoprostol is advised after 36-48 hours of taking Mifepristone. However, Misoprostol should only be taken under the supervision of a gynecologist, at a clinic or hospital setting.
What should I expect after completing my course of Safe-T Kit?
After taking Mifepristone, you may or may not experience vaginal bleeding. However, you may experience abdominal cramping, diarrhea, stomach pain, and nausea immediately after taking Misoprostol. You may also have vaginal bleeding within 4 hours of taking Misoprostol. You may also be asked to stay at the clinic or healthcare center for at least 3 hours after taking this medicine. After 14 days of taking Mifepristone (pill you took before Misoprostol), your gynecologist may run some blood tests or perform ultrasonography to confirm whether pregnancy has been terminated or not.
Can Safe-T Kit affect my future chances of getting pregnant?
No, studies have shown that this medicine does not impair the fertility of the women. Your future chances of getting pregnant are as equal as those who have not taken this medicine.
What are the common side effects of taking Safe-T Kit?
The common side effects of using Safe-T Kit are abdominal pain, abdominal cramping, nausea, diarrhea, dizziness, uterine contractions, pelvic pain, and shivering. If you experience a very heavy vaginal bleeding or if any of these side effects bother you please consult with your gynecologist.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Shaw KA, Topp NJ, Shaw JG, et al. Mifepristone-misoprostol dosing interval and effect on induction abortion times: a systematic review. Obstet Gynecol. 2013 ;121(6):1335-1347. [Accessed 29 Nov. 2025]. Available from:
- Esposito L, Kornfield MS, Rubin E, et al. Mifepristone-misoprostol combination treatment for early pregnancy loss after embryo transfer: a case series. F S Rep. 2023;4(1):93-97. [Accessed 29 Nov. 2025]. Available from:
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