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RIMTHREE FDC 150MG/75MG/275MG TABLET

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MRP: Rs. 41.53 for 1 strip(s) (10 tablets each)
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Composition for RIMTHREE FDC

Rifampicin(150 mg),Isoniazid(75 mg),Ethambutol(275 mg)

food interaction for RIMTHREE FDC

alcohol interaction for RIMTHREE FDC

pregnancy interaction for RIMTHREE FDC

lactation interaction for RIMTHREE FDC

food
alcohol
pregnancy
lactation
Avoid Rimthree fdc 150mg/75mg/275mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
UNSAFE
Rimthree fdc 150mg/75mg/275mg tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
UNSAFE
Rimthree fdc 150mg/75mg/275mg tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Rimthree fdc 150mg/75mg/275mg tablet is probably safe to use during breastfeeding. Please consult your doctor.
SAFE

SALT INFORMATION for RIMTHREE FDC

Rifampicin(150 mg)

Uses

Rifampicin is used in treatment of tuberculosis (TB) and leprosy.

How it works

Rifampin is an antibiotic and kills a wide range of infection causing bacteria (broad spectrum). It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which is essential for important life processes in the bacteria, thereby killing the bacteria.

Common side effects

Vomiting, Nausea, Abnormal liver function tests, Acute renal failure, Irritation of ear, Allergic skin rash, Diarrhoea, Hemolytic anemia, Jaundice, Loss of appetite, Reduced blood platelets, Fever, Drowsiness, Headache
Isoniazid(75 mg)

Uses

Isoniazid is used in the treatment and prevention of tuberculosis (TB).

How it works

Isoniazid belongs to a class of antituberculosis drugs. It suppresses the growth of tuberculosis causing bacteria (Mycobacterium tuberculosis). It interferes with the formation of the outer protective covering (cell wall) of the bacteria by inhibiting the synthesis of a chemical called mycolic acid an essential component of cell wall.

Common side effects

Vomiting, Nausea, Inflammation of the optic nerve of the eye, Peripheral neuropathy, Agranulocytosis (deficiency of granulocytes in the blood), Aplastic anemia, Diarrhoea, Dry mouth, Gastrointestinal disorder, Haemolytic anemia, Hepatitis (viral infection of liver)
Ethambutol(275 mg)

Uses

Ethambutol is used in the treatment of tuberculosis (TB).

How it works

Ethambutol belongs to a class of anti-tuberculosis drugs. It suppresses the growth of tuberculosis causing bacteria (Mycobacterium tuberculosis). Ethambutol enters the growing bacteria and kills the bacteria by inhibiting an important enzyme arabinosyl tranferases involved in the formation of the outer protective covering of the bacteria called cell wall.

Common side effects

Tingling sensation of extremity, Numbness of extremity, Abnormal liver function tests, Altered vision, Blurred vision, Color blindness, Rash, Itching, Loss of appetite, Stomach upset, Vomiting

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Top Physicians

  • Dr. Khoobsurat Najma
    MBBS
    4.9
  • Dr. Prabhat Kumar Jha
    MBBS, MD
    4.7
  • Dr. Sushila Kataria
    MBBS, MD, Diploma
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  • Dr. R. S. Rawat
    MBBS, MD
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  • Dr. R. R. Dutta
    MBBS, MD
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Expert advice for RIMTHREE FDC

  • Rifampin interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do consult your doctor before taking rifampin if you wear contact lenses. Using rifampin may permanently stain your contact lenses.
  • Taking rifampin may produce a brownish-red coloration of the urine, sweat, sputum and tears. This is not a harmful effect.
  • Do consult your doctor before taking rifampin if you are pregnant or planning to become pregnant.
  • Do consult your doctor if you are taking oral contraceptive medications for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking rifampin.
  • Do consult your doctor before taking rifampin if you are breast-feeding.
  • Do consult your doctor before taking rifampin if you are aged 65 years or above.
  • If you take rifampin irregularly or if daily administration is resumed after a drug free interval, you may experience ‘flu syndrome’ (includes episodes of fever, chills, headache, dizziness, and bone pain).
  • Rifampin should preferably be taken in the morning before breakfast. Taking rifampin with food is known to delay its absorption (process by which the active drug reaches the affected site in the body via blood circulation) thereby, hampering its effectiveness.
  • Do not stop taking rifampin without consulting your doctor.

Frequently asked questions for RIMTHREE FDC

Rifampicin

Q.Is rifampin and rifampicin same?
Yes. Rifampin (nomenclature in the United States) and rifampicin (nomenclature in Britain) is the same antibiotic commonly used in the treatment of tuberculosis and leprosy

Q.Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Q.Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Q.Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Q.What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

Q.What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Q.Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Q.Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin

Q.Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Q.Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Isoniazid

Q.Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)

Q.Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer

Q.Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth

Q.Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor

Q.Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)

Q.Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs

Q.Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Q.Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis

Q.Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q.Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Ethambutol

Q.Does ethambutol cause blindness?
Optic neuritis (inflammation of nerve fibers that transmit visual information from your eye to the brain) is one of the side effects of ethambutol which causes several forms of eye defect. Although these conditions are reversible upon discontinuation of the drug, rare cases of irreversible blindness have also been reported. Please contact your doctor immediately if you notice any of these symptoms: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain

Q.Does ethambutol induce hyperuricemia/how does ethambutol induce hyperuricemia?
Yes. Increase in blood levels of uric acid is a side effect of ethambutol. It increases the retention of uric acid in the body by decreasing the excretion of urates (uric acid) by the kidneys

Q.How does ethambutol work in the body?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It suppresses the growth of the bacteria by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening the bacteria

Q.What is ethambutol toxicity/How does ethambutol cause optic neuritis/how does ethambutol affect vision?
Ethambutol toxicity involves toxic effects on the eyes (optic neuritis/optic neuropathy) which are related to the dose and duration of ethambutol treatment. It causes optic neuritis (inflammation of nerve fibers in the eye) by interfering with important cellular activities (mitochondrial toxicity) in the nerve cells and inducing nerve damage (neuropathy) thereby affecting the transmission of visual information from the eye to brain. The symptoms of ethambutol induced optic neuritis include: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain

Q.What does ethambutol treat?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It is used in the prevention, treatment and second time treatment of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)

Q.Is ethambutol bacteriostatic or bactericidal?
Ethambutol is both a bacteriostatic and a bactericidal antibiotic. It suppresses the growth of bacteria (bacteriostatic) by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening it and causing cell death in certain cases (bactericidal)

Q.Is ethambutol hepatotoxic?
Liver toxicities are among the known side effects of ethambutol. Inflammation of liver (hepatitis), abnormal liver function causing yellowing of skin and eyes (jaundice), abnormal liver function tests (blood tests to assess health of liver) and very rarely liver failure have been noted in patients receiving multi drug (including ethambutol) treatment for tuberculosis. Please contact your doctor before taking ethambutol if you have any liver problems

Q.Is ethambutol toxicity reversible?
In most cases ethambutol toxicities are related to dose (depends upon the quantity of ethambutol you take) and duration of treatment and are reversible upon discontinuation. However, serious irreversible damage to eye and liver has been reported in rare cases

Q.Is ethambutol chemotherapy?
Ethambutol is an antibiotic used in the treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer

Q.Ethambutol is effective against?
Ethambutol is effective against most tuberculosis causing bacteria belonging to Mycobacterium family (M. tuberculosis, M. avium complex, M. kansasii, M. marinum).

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Content on this page was last updated on 26 September, 2014, by Dr. Varun Gupta (MD Pharmacology)