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16 Oct 2019 | 01:31 PM (IST)
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Rifacil 450mg Tablet


Overview

Introduction

Rifacil 450mg Tablet is an antibiotic. It is used in the treatment of tuberculosis and leprosy.

Rifacil 450mg Tablet should be taken in the dose and duration as advised by the doctor. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.

Some people may develop side effects like low blood platelets, headache, dizziness, vomiting, nausea and chills. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Your urine, tears and other secretions may become orange-red in colour due to Rifacil 450mg Tablet. You should avoid using contact lenses since they may become discolored.

Before starting treatment with this medicine, you should tell doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests for liver function test while using Rifacil 450mg Tablet.

Uses of Rifacil Tablet

Side effects of Rifacil Tablet

Common
  • Low blood platelets
  • Headache
  • Dizziness
  • Vomiting
  • Nausea
  • Fever
  • Altered liver function test
  • Chills

How to use Rifacil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifacil 450mg Tablet is to be taken empty stomach.

How Rifacil Tablet works

Rifacil 450mg Tablet is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Rifacil 450mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Rifacil 450mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Rifacil 450mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Rifacil 450mg Tablet may cause side effects which could affect your ability to drive.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.
Kidney
CAUTION
Rifacil 450mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Rifacil 450mg Tablet may be needed. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Rifacil 450mg Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Rifacil Tablet?

If you miss a dose of Rifacil 450mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Rifacil 450mg Tablet
₹6.2/Tablet
₹5.8/Tablet
save 6%
Monocin 450mg Tablet
Overseas Healthcare Pvt Ltd
₹3.95/Tablet
save 36%
Ticin 450mg Tablet
Themis Medicare Ltd
₹4.65/Tablet
save 25%
RF 450mg Tablet
Sunij Pharma Pvt Ltd
₹4.14/Tablet
save 33%
Rimactane 450mg Tablet
Novartis India Ltd
₹4.24/Tablet
save 32%

Quick Tips

  • Your doctor has prescribed Rifacil 450mg Tablet to cure your infection and improve symptoms.
  • It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food. 
  • Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
  • Tell your doctor about all other medicines you are taking as Rifacil 450mg Tablet can interact with many medicines.
  • Avoid taking hormone-based birth control methods as Rifacil 450mg Tablet may decrease their effectiveness.
  • Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.

Interaction with Drugs

Taking Rifacil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Aprepit, Aprepep, Fos-Aprepitant
LIFE-THREATENING
Brand(s): Atazor, Atavir, Virataz
LIFE-THREATENING
Brand(s): Hypnite, Zopimin S, Zolnite
LIFE-THREATENING
Brand(s): Inbec
LIFE-THREATENING

Patient Concerns

arrow
Extra pulmonary tuberculosis mdr tb for spinal card treatment
Dr. Sunil Sekhri
Diabetes Specialist
This needs to be examined and treated in the clinic
Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment?
Dr. Anshum Aneja Arora
Lungs Specialist
If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis
arrow
Do you have any questions related to Rifacil 450mg Tablet ?

FAQs

Q. Is rifampin a penicillin/amoxicillin/sulfa drug?

No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Q. Is rifampin bacteriostatic or bactericidal?

Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Q. Is rifampin an inducer or inhibitor?

Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Q. What is R-cin 600 used for?

R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

Q. What is R-cinex/Macox plus/R-cinex 600?

R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Q. Does rifampin cause headaches?

Yes. Headache is a possible side effect of rifampin

Q. Does rifampin change urine color/turn urine orange?

Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Q. Does rifampin cause liver damage?

Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1213-14.
  3. Drugs.com. Rifampicin. [Accessed 01 Apr. 2019] (online) Available from:External Link
  4. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from:External Link
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