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food interaction for RGM

alcohol interaction for RGM

pregnancy interaction for RGM

lactation interaction for RGM

There is no data available. Please consult doctor before consuming the drug.
Taking metformin with alcohol may cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
Taking rosiglitazone with alcohol may affect blood glucose levels in patients with diabetes.
Rgm 5mg/500mg/2mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Glibenclamide(5 mg)


Glibenclamide is used to lower the blood sugar level in patients with type 2 diabetes mellitus that is not controlled by diet and exercise alone.

How it works

Glibenclamide also known as glyburide is one of a group of medicines called sulphonylurea and it acts by promoting insulin secretion in the body, so that the blood sugars are utilized by various organs, leading to a fall in blood levels of sugar. 

Common side effects

Nausea, Anxiety, Bruise, Bleeding, Dark colored urine, Diarrhoea, Fever, Dizziness, Flatulence, Loss of appetite, Rash, Itching, Skin redness, Sore throat, Stomach pain / epigastric pain
Metformin(500 mg)


Metformin is an antidiabetic medicine that helps to control blood sugar in people with type 2 diabetes mellitus.

How it works

Metformin belongs to class of medications called antidiabetics.It decreases the amount of glucose absorbed from the food and the amount ofglucose made by liver. Metformin also increases the body's response to insulin(a natural substance that controls the amount of glucose in the blood).

Common side effects

Flatulence, Muscle pain, Abdominal bloating, Chest pain, Skin rash, Flushing, Abdominal pain, Nail disorder, Diarrhoea, Headache, Indigestion, Bitter taste, Constipation, Allergic reaction, Heartburn
Rosiglitazone(2 mg)


Type 2 diabetes mellitus.

How it works

Rosiglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

Common side effects

Vomiting, Nausea, Back pain, Cardiac disorder, Cold symptoms, Nasal congestion, Fluid retention, Limb swelling, Headache, Loss of appetite, Running nose, Sore throat, Stomach pain


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Expert advice for RGM

Make sure you follow all exercise and dietary recommendations made by your doctor or dietitian. Swallow the whole tablet with or immediately after breakfast or the first main meal.Take glibenclamide exactly as directed by your doctor. Do not stop taking glibenclamide without consulting your doctor. Do not take glibenclamide;
  • If you are allergic to glibenclamide or any of the other ingredients of this medicine.
  • If you have type 1 diabetes mellitus or have had impaired consciousness due to severe diabetes, liver or kidney disease, or deficiency of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).
  • If you are pregnant or breast-feeding.
Do inform your doctor if you are about to have major surgery or have had a recent injury (trauma) or develop a fever or severe infection.

Frequently asked questions for RGM


Q. Is glibenclamide/Daonil/Euglucon same as glyburide?
Yes. Daonil/ Euglucon are the trade names for the active substance (generic) glibenclamide/ glyburide; thus, they all are same.
Q. Is glibenclamide same as glipizide?
No. Glibenclamide and glipizide are different medicines; however, they belong to same family of drugs called sulfonylureas.
Q. Why is glibenclamide avoided in the elderly?
Glibenclamide should be avoided in elderly patients because they are at high risk of getting low blood sugar (hypoglycemic event).
Q. What is glibenclamide/Daonil/ Euglucon used for?
Glibenclamide/Daonil/ Euglucon is used for the treatment of type 2 diabetes.
Q. Does Daonil/ glibenclamide cause weight gain/ weight loss?
Yes Daonil/ glibenclamide are known to cause weight gain but not weight loss. Always consult your doctor if you experience such side effects.


Q. Is Metformin a birth control pill/ insulin / statin/ banned drug?
Metformin (also available as glyciphage, glycomet, glycomet SR) is an antidiabetic drug used in treatment of type 2 diabetes mellitus, particularly in overweight patients, as an adjunct to the diet and exercise.
Q. Is metformin safe?
Metformin is generally safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Can I take metformin forever?
Metformin should be taken at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is metformin good for weight loss / weight loss in non-diabetics?
Metformin is used for the treatment of type 2 diabetes mellitus, particularly in overweight patients. 


Content on this page was last updated on 12 February, 2016, by Dr. Varun Gupta (MD Pharmacology)