R-Loc 25 mg Injection

Prescription Required


Uses of R-Loc Injection

R-Loc 25 mg Injection is used in the treatment of gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

R-Loc Injection side effects

  • Sleepiness
  • Headache
  • Tiredness
  • Constipation
  • Diarrhea

How to use R-Loc Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How R-Loc Injection works

R-Loc 25 mg Injection is a H2 blocker (antacid). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

R-Loc Injection related warnings

Alcohol use can increase acid secretion, acid reflux in food pipe causing heartburn and decreasing effect of this drug. R-Loc 25 mg Injection can also decrease alcohol breakdown and increase its level in blood.
R-Loc 25 mg Injection is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
R-Loc 25 mg Injection is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
R-Loc 25 mg Injection does not usually affect your ability to drive.
R-Loc 25 mg Injection should be used with caution in patients with kidney disease. Dose adjustment of R-Loc 25 mg Injection may be needed. Please consult your doctor.
R-Loc 25 mg Injection should be used with caution in patients with liver disease. Dose adjustment of R-Loc 25 mg Injection may be needed. Please consult your doctor.

What if you miss a dose of R-Loc Injection?

If you miss a dose of R-Loc 25 mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
R-Loc 25 mg Injection
Rantac 25mg Injection
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Zinetac 25mg Injection
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₹1.98/ml of Injection
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Aciloc Injection
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Expert Advice

  • R-Loc 25 mg Injection is a well tolerated and safe medicine with a very low incidence of side effects.
  • Take R-Loc 25 mg Injection before going to bed if you are taking this medicine once a day as it is very effective in controlling stomach acid released in the midnight.
  • If you are also taking an antacid, take it two hours before or after taking R-Loc 25 mg Injection.
  • Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
  • Inform your doctor if you do not feel better after taking R-Loc 25 mg Injection for two weeks or 14 days as you may be suffering from some other problems.
  • Inform your doctor if you have ever been diagnosed with kidney or liver disease. Dose of your medicine may need to be adjusted.

Interaction with Drugs

Taking R-Loc with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Exeed, Metcalf, Estimet
Brand(s): Indizole, Itraspan, Itzo
Brand(s): Diadose
Brand(s): Vogmax
Brand(s): Euroglip, Pridex MG, Glimpee
Brand(s): Stoin
Brand(s): Diabic, Glicla
Brand(s): Fungis, EF Z

Patient Concerns

Questions Related to R-Loc

upper abdominal problem with gastric history. using RabletD tablet regularly but the pain is chronic since yesterday till now. please help Doctor
Dr. Anshul Varshney
General Physician
Hello, Welcome to 1mg. I am Anshul Varshney for your help. I would advice you to go for an Upper GI Endoscopy and Ultrasound Abdomen for the same. You might be having Gall bladder issues or Peptic ulcer disease.
Do you have any questions related to R-Loc 25 mg Injection?


Q. Does R-Loc interfere with H. pylori test results?

A significant number of patients infected with Helicobacter pylori can have negative test results if they are using R-Loc as it interferes with the urea breath test, which is done to identify H. Pylori infection.

Q. Does R-Loc cause glaucoma?

R-Loc itself does not cause glaucoma. However, there are some rare reports that R-Loc can increase the intraocular pressure in patients who have glaucoma. Inform your doctor in case you have glaucoma or high intraocular pressure before taking this medicine.

Q. Can R-Loc be used to treat gastritis?

Yes, R-Loc can be used for the short-term treatment of gastritis. It helps by decreasing the amount of acid released into the stomach and relieving stomach pain and acid reflux.

Q. Is R-Loc safe?

Yes, R-Loc is safe if used at prescribed doses for the prescribed duration as advised by the doctor. However, there are some very common side effects that you can experience at the doses advised like nausea, abdominal pain, constipation, diarrhea, and flatulence.

Q. Is R-Loc an over the counter (OTC) drug?

No, R-Loc is not an over-the-counter product. It is a prescription medicine and is available only when prescribed by a physician.

Q. Can Vitamin B along with R-Loc?

Yes, Vitamin B can be taken along with R-Loc. No drug-drug interactions have been reported between this medicine and vitamin B.

Q. Why R-Loc is given along with vitamin B12?

Long term use of R-Loc can cause vitamin B12 deficiency as it decreases the acid secretion in the stomach which is required for the absorption of Vitamin B12. To prevent this deficiency, vitamin B12 may be advised by your doctor along with this medicine.

Q. Can a patient with hepatitis C take R-Loc?

Yes, a patient of hepatitis C can take R-Loc, however, this should be taken under medical supervision. R-Loc belongs to the group of drugs called H2 blockers which have been seen to increase the risk of hepatic encephalopathy in hepatitis C patients. So, this group of medicines should be used with caution in patients with underlying liver disease.

Q. Can I take Vitamin D along with R-Loc?

Yes, Vitamin D can be taken with R-Loc.

Q. Can the use of R-Loc cause headache?

Headache is reported as one of the common side effects of R-Loc. Inform your doctor in case you experience headache for a prolonged duration while taking R-Loc.

Q. What is the role of R-Loc in critically ill patients?

R-Loc may be used in critically ill patients to decrease stomach acid secretion and lower the risk of acid aspiration into the lungs. It also helps in decreasing stomach ulcers and gastrointestinal bleeding in these patients.

Q. What foods should be avoided when you are taking R-Loc?

You should preferably avoid foods that cause acidity and heartburn as they would aggravate your disease condition, for example: fried foods, prepared in butter or oil, fat rich foods, tomato-based foods and juices, caffeinated drinks like cola, tea, drinks from citrus fruits like lemon water or orange juice and alcohol-containing drinks.

Q. Can R-Loc be used for reflux esophagitis?

Yes, R-Loc is effective in the treatment of reflux esophagitis.

Q. Does R-Loc treat irritable bowel syndrome (IBS)?

R-Loc is not routinely used for the treatment of irritable bowel syndrome (IBS). It is given if there is associated dyspepsia or increased stomach acid secretion. IBS is managed with a combination of antispasmodics (to relieve stomach pain), laxatives (to relieve constipation), and anti motility drugs (to relieve diarrhea).

Q. Why is R-Loc given with cancer drugs?

R-Loc may be used for multiple reasons in cancer patients. It can lower stomach acid volume in patients undergoing chemotherapy to prevent aspiration and lower the risk of stomach ulceration and bleeding. According to some studies, R-Loc can potentiate white blood cell against cancer cells and can be helpful in the treatment of cancer.

Q. Is R-Loc used to treat nausea?

R-Loc is used for the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers and can help in providing relief in nausea that may happen due to acid reflux. It is not used to treat nausea due to any other cause. Rather, nausea is one of the most common side effects of R-Loc.

Q. What is the benefit of taking R-Loc with pantoprazole?

Both R-Loc and pantoprazole lower gastric acid secretion, however, they work by different mechanisms. If you have been advised to take pantoprazole, you can also take R-Loc initially for rapid relief of heartburn and acid reflux as pantoprazole may take a few days to show its effect and provide relief.

Q. Can I take R-Loc with pain killers?

Yes, R-Loc can be taken with painkillers. R-Loc can help to prevent painkillers induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. Moreover, there are no clinically significant interactions of R-Loc with painkillers.

Q. What are the serious side effects associated with the use of R-Loc?

Some serious side effects associated with the use of R-Loc are bone marrow hypoplasia (decreased formation of blood cell components), anaphylactic shock (severe allergic reactions) sinus bradycardia (lowering of heart rate) and acute pancreatitis (inflammation of the pancreas).

Q. Why does R-Loc cause diarrhea?

Use of R-Loc lowers the natural stomach acid which normally helps to kill bacteria. So, use of R-Loc leads to overgrowth of the harmful bacteria like clostridium difficile which can cause diarrhea. This is known as clostridium difficile–associated diarrhea (CDAD). Inform your doctor if you have loose stools many times in a day and for many days with stomach cramps and fever.

Q. Is R-Loc effective?

R-Loc would be effective only if used for the right indication in the dose and for the duration as advised by the doctor. In case you do not find any change in your disease condition while taking this medicine, please talk to your doctor. Do not change the dose or stop taking the medicine without consulting your doctor.

Q. Can I smoke while taking R-Loc?

It is better to avoid cigarette smoking when you are taking R-Loc. As studies have shown that the effectiveness of R-Loc is lower in smokers compared to non-smokers. Moreover, smoking may add to gastric problems leading to more production of gastric acid.

Q. Can the use of R-Loc cause iron deficiency?

Yes, use of R-Loc can cause iron deficiency and a decrease in hemoglobin levels as it decreases the acidic environment of the stomach needed for the absorption of iron. However, there are no recommendations on the regular monitoring of iron levels or taking iron supplements when the patient is taking R-Loc but you can maintain good dietary nutrition so that no deficiency occurs.

Q. Is there any known role of R-Loc before surgery?

R-Loc is given as a part of pre-anesthetic medication before surgery to decrease the stomach acid secretion so that stomach acid is not aspirated into the lungs during surgery as this may complicate or delay the procedure.

Q. Does R-Loc cause flatulence (gas or bloating)?

Flatulence (gas) has been reported as a common side effect of R-Loc. Although it would be mild to moderate in nature and it goes away once you stop taking R-Loc.

Q. Is R-Loc an antihistaminic drug?

Yes, R-Loc is an antihistaminic drug. It acts on histamine receptors in the stomach and blocks the action of a chemical messenger histamine (causes acid secretion in stomach) and hence decreases the acid production in the stomach.

Q. Can the use of R-Loc cause constipation?

Yes, the use of R-Loc can cause constipation. It is one of the common side effect seen with R-Loc. Taking high fiber diet and plenty of fluids can help in relieving constipation and can also help in decreasing acidity.

Q. Is R-Loc useful in the prevention of painkiller (NSAID) induced gastric ulcers?

Yes, R-Loc is useful for the prevention of painkiller (non-steroidal anti-inflammatory drug - NSAID) induced gastric ulcers. These may cause dull pain in the stomach, sudden weight loss, loss of appetite, nausea, vomiting or bloating. Avoid stress and spicy foods as they can make your symptoms worse.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 8th Mar 2017.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.
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