Do not have any immunizations/vaccinations while using this medication without the consent of your doctor.
Contact your doctor immediately if you experience symptoms such as persistent nausea, vomiting, feeling of discomfort (malaise) or jaundice (abnormal liver function causing yellowing of skin and eyes) while taking pyrazinamide. It indicates that you are developing liver disease.
Constant monitoring of liver function (especially levels of enzymes aspartate transferase [AST] and alanine transferase [ALT]) and blood uric acid levels is advised while on treatment with pyrazinamide.
Do consult your doctor before taking pyrazinamide if you are pregnant or planning to become pregnant.
Do not use pyrazinamide, if you are breast-feeding.
Do not stop taking pyrazinamide without consulting your doctor.
If you forget to take a dose of pyrazinamide, take it as soon as you remember. Do not double the dose to make up for the missed dose.
Do consult your doctor if you are taking oral contraceptive medications (hormonal birth control pills) for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking pyrazinamide.
Interaction with alcohol is unknown. Please consult your doctor.
WEIGH RISKS VS BENEFITS
Pyriza 750mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Pyriza 750mg Tablet is probably safe to use during lactation
Limited human data suggests that the drug does not represent a significant risk to the baby.
It is not known whether Pyriza 750mg Tablet alters the abili
ty to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Pyriza 750mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Pyriza 750mg Tablet may be needed. Please consult your doctor.
Kidney function tests are advised before you start taking this medicine.
Pyriza 750mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Pyriza 750mg Tablet may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised before and after the start of the treatment.
Pyriza is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Following oral intake of Pyriza, it gets converted in the body to pyrazinoic acid (active chemical form of Pyriza). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
Information last updated by Dr. Varun Gupta, MD Pharmacology on 8th Mar 2017.