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Composition for PROTHIADEN-M

Dosulepin(50 mg),Methylcobalamin(1500 mcg)

food interaction for PROTHIADEN-M

alcohol interaction for PROTHIADEN-M

pregnancy interaction for PROTHIADEN-M

lactation interaction for PROTHIADEN-M

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Prothiaden-m 50 mg/1500 mcg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Dosulepin(50 mg)


Dosulepin also called as dothiepin is used to treat major depressive disorders and neuropathic pain.

How it works

Dosulepin belongs to a class of medication call tricyclic anti-depressants. It acts on the central nervous system by blocking release of certain chemicals thus producing an anti-depressive effect. It is a serotonin-norepinephrine reuptake inhibitor (SNRI).

Common side effects

Flushing, Gastrointestinal disturbance, Decreased white blood cell count
Methylcobalamin(1500 mcg)


Methylcobalamin is an active form of vitamin B12, which is used to treat anemia as well as nerve damage with numbness, tingling, pain in various neurological disorders.

How it works

Methylcobalamin plays a key role in recovery process of damaged nerve cells and also it maintainins proper function of nerve cells.

Common side effects

Gastrointestinal disturbance, Allergic skin rash


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Expert advice for PROTHIADEN-M

Do not take the medicine, If you are allergic to dosulepin, take it as single dose preferably at night.
Consult your doctor before taking dosulepin:
  • If you are an elderly patient.
  • If you have problems of bed wetting at night.
  • If you have ever had a heart attack.
  • If you are pregnant or planning to become pregnant or breast-feeding a baby.
Do not drive or operate machines after taking dosulepin as it may cause dizziness or tiredness.

Frequently asked questions for PROTHIADEN-M


Q. What is dosulepin?
Dosulepin is and SNRI (serotonin-norepinephrine reuptake inhibitor) and its chemical structure class is tricyclic antidepressant.

Q. Is it an SSRI (selective serotonin reuptake inhibitor)/ tricyclic antidepressant/ MAOI (monamine oxidase inhibitors)/muscle relaxant?
 It is not an SSRI/MAOI/muscle relaxant.
Q. How does dosulepin work?
Dosulepin belongs to a class of medication call tricyclic anti-depressants. It acts on the central nervous system by blocking release of certain chemicals thus producing an anti-depressive effect.
Q. Is dosulepin the same as doxepin?
Dosulepin has some structural similarity with doxepin, but it is not the same as doxepin.
Q. Is dosulepin safe or addictive?
Dosulepin is safe if used for an indication and a dose prescribed by your doctor. It may be addictive and hence should be taken only under the supervision of a doctor.
Q. Can I take Tramadol, Sertraline, Diazepam/Amitriptyline/Paracetamol/Zopiclone/ Gabapentin/Ibuprofen?
Dosulepin is known to interact with sertaline (SSRI anti-depressant), Diazepam (benzodiazepine-anti anxiety), amitriptyline (tricyclic antidepressant), zopiclone (cyclopyrrolone) /Gabapentin (Neurontin for seizure). It is not known to interact with Tramadol (pain-killer)/Paracetamol/Ibuprofen. Doctor’s permission must be clearly sort for taking any other drug along with dosulepin.
Q. Can dosulepin cause weight gain/anxiety/sleep loss/headache/low or high blood pressure/decrease in sperm count?
Dosulepin is known to have side effects like anxiety, sleep loss/headache/low or high blood pressure. It is not clearly known to cause weight gain or decrease sperm count. It may cause an increase or decrease in sexual desire.


Q. What is methylcobalamin/ mecobalamin/Neurokind/ Nurokind OD?
Methylcobalamin (mecobalamin/Neurokind/ Nurokind OD) is an active form of vitamin B12. It is water soluble and orally absorbed. It  is found in animal-based foods and in supplement form.

Q. Is methylcobalamin the same as cyanocobalamin?
No.Cyanocobalamin is different form of vitamin B12.

Q. What is Nurokind G, Nurokind plus, Nurokind Next, Nurokind LC, Nurokind Gold?
Nurokind G contains methylcobalmine and gabapentin. Nurokind plus contains methylcobalamin, folic acid, vitamin B1, vitamin B6 and alfa lipoic Acid. Nurokind Next contains methlcobalamin, alphalipoic acid, benfotiamine, pyridoxine hydrochloride, biotin, folic acid, chromium. NurokindL C contains L-carnitine, L-tartrate, methylcobalamin, folic acid. Nurokind Gold contains ginseng extract, mixed carotene 10%, niacinamide, vitamin B6, methylcobalamin, vitamin D3, refined wheat germ oil, folic acid, elemental calcium, elemental phosphorus, ferrous fumarate, zinc sulfate mono hydrate, elemental magnesium, elemental manganese, elemental copper, elemental iodine, elemental potassium.


Content on this page was last updated on 18 October, 2016, by Dr. Varun Gupta (MD Pharmacology)