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MRP: Rs. 236.91 for 1 tube(s) (3 GM gel each)
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Composition for PRIMIGYN

Dinoprostone Topical(0.5 mg)

food interaction for PRIMIGYN

alcohol interaction for PRIMIGYN

pregnancy interaction for PRIMIGYN

lactation interaction for PRIMIGYN

It can be taken with or without food, but it is better to take Primigyn 0.5 mg gel at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Primigyn 0.5 mg gel may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Primigyn 0.5 mg gel is probably safe to use during breastfeeding. Please consult your doctor.


Dinoprostone Topical(0.5 mg)


Primigyn 0.5 mg gel is used to induce labor in pregnant women who are at or near term (38 weeks).

How it works

Dinoprostone belongs to the class of medications called as prostaglandins. It is similar to a naturally occurring substance called prostaglandin E2 in body. It helps to initiate the birth process by relaxing the muscles of cervix and promoting contractions of uterus thereby inducing the labor.

Common side effects

Vomiting, Nausea, Diarrhoea, Increased uterine contractions


2 Substitutes
Sorted By
    (3 GM gel in tube)
    Astra Zeneca
    Rs. 86.83/GM of gel
    Rs. 260.50
    pay 10% more per GM of gel
    (3 GM gel in tube)
    Neon Laboratories Ltd
    Rs. 81/GM of gel
    Rs. 243
    pay 3% more per GM of gel

Expert advice for PRIMIGYN

  • During dinoprostone topical administration, you may be asked to remain in lying down position for 20-30 minutes to keep the medication in place. Your doctor may decide to give a second dose of medicine if contractions are not strong enough.
  • You may be monitored closely after administration of dinoprostone topical to check if the birth canal is opening, the contractions are not too strong and to ensure the baby does not get distressed. 
  • Inform your doctor if you are asthmatic and if you develop difficulty in breathing after the medication, as dinoprostone topical could cause an asthma attack.
  • Inform your doctor if you have an eye problem (glaucoma), fits (epilepsy), diabetes, high blood pressure (hypertension) in the current or any previous pregnancies, have undergone caesarean or any uterine surgery or if you have had abnormally strong contractions or scarring of your womb during previous labor or are taking medicines for pain and/or inflammation (e.g. aspirin).
  • Do not use if you are allergic to dinoprostone or any of its ingredients.
  • Do not use if you have severe heart, lung, kidney or liver disease.
  • Do not use if you had a caesarean section, major surgery of the womb or have had six full-term pregnancies.
  • Do not use by the patients in whom the size of the baby’s head is too large or there is evidence that baby is short of oxygen (fetal distress).
  • Do not use by the patients in whom the baby is not in the correct position in the womb, to be born naturally or waters have broken or the placenta is obstructing the birth canal.
  • Do not use if you have a history of difficult labor in a previous pregnancy or existing untreated infection of womb, ovaries or tubes (pelvic inflammatory disease).
  • Do not use if you have unexplained bleeding from vagina during pregnancy.
  • Children and elderly must not use.

Frequently asked questions for PRIMIGYN

Dinoprostone Topical

 Q. What is dinoprostone topical made from/does dinoprostone work? 
Dinoprostone is a naturally occurring substance called prostaglandin. It softens and opens the part of the birth canal known as the cervix thereby inducting the labor (a process in which the womb starts contracting).


Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)