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Caffeine is used in combination with pain killers (aspirin and paracetamol) to ease pain that includes headache, migraine, neuralgia, toothache, sore throat, period pains, relief of sprains, strains, rheumatic pain, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds. As caffeine citrate, it is used to treat absence of breathing seen in newborns (primary apnea of premature newborns).

How it works

Caffeine is a drug which belongs to a group of medicines called methylxanthines. Caffeine acts against a chemical called adenosine in the body, and thereby reduces pain. Caffeine also stimulates the brain (central nervous system), heart, and muscles and improves the drive to breathe.

Common side effects

restlessness, can cause tremors and fluttering sensation in the chest . In higher doses, abdominal pain, caffeine causes CNS stimulation, confusion, stomach pain, swelling and redness at the site of infusion.Rare: Severe allergic reaction.Frequency not known: serious intestinal disease with bloody stools and all other side-effects mentioned with the tablet formulation., muscle twitching, however, When caffeine is taken as a combination tablet with pain-killers, anxiety, most of the side-effects are attributable to the pain-killers. Caffeine, it can cause the following side-effects:Common: pain, fits, irregular heartbeats, sleeplessness, increased urination and facial flushing. When given as an intravenous solution to treat primary apnea of premature infants, nervousness, increased heart rate, excitement



Mesalazine (also known as mesalamine) is used for the treatment and prevention of short episodes of ulcerative colitis (inflammatory disease of colon) and Crohn’s ileocolitis (inflammation of lining of ileum and colon).

How it works

Mesalazine belongs to a class of drugs called as amino salicylate drugs. It acts locally in the intestine to reduce the inflammation and prevents further swelling, ulcers or abscess (puss filled swelling).

Common side effects

inflammation of heart muscles, muscle, Nausea, abdominal pain, abnormal blood counts, inflammation of liver, vomiting, skin rashes, changes in levels of liver enzyme and kidney failure., diarrhea, constriction of air passages, hair loss, headache, inflammation of heart lining, joint or bone pain and stiffness or myalgia, inflammation of pancreas


No substitutes found

Expert advice

  • For relief of pain, consume the medicine only at recommended doses. Immediately consult doctor in case you take more than the prescribed/ recommended dose even if you feel well. Also consult the doctor if the symptoms last for more than 3 days despite taking the medicine.
  • Preparations of caffeine and ergot derivatives have been discontinued in view of patient safety.
  • When caffeine citrate solution is used for premature apnea of newborns, remember to use one vial of the drug for one dose. Throw away the left-over solution after required amount is used.

Frequently asked questions


Q. What is caffeine? 
Caffeine is a drug which belongs to a group of medicines called methylxanthines. It is also present in tea, coffee, some chocolates and soft drinks, in addition to some medicines. It acts on the brain to increase alertness and energy levels. However, too much caffeine is harmful.

Q. Is caffeine alcohol? 
No, caffeine is not alcohol; it belongs to a group of medicines called methylxanthines. It acts on the brain to increase alertness and energy levels. However, it must be remembered that too much caffeine is harmful.

Q. Is caffeine good or bad?
Caffeine; if taken as medicine for recommended indications and in adequate dosage it provides beneficial effects. Too much caffeine is harmful. Always consult your doctor if you get any of the bad effects or side effects after use of caffeine.

Q. Is caffeine good for hair?
There is no report available on the use of caffeine and hair growth. Patients should follow the advice of the doctor regarding its use.

Q. Is caffeine addictive?
No, caffeine is not in the list of addictive drugs. Addiction is said to occur when there is persistent, compulsive dependence on a behavior or substance; without treatment or engagement in recovery activities, addiction is progressive and can result in disability or premature death. Caffeine does not meet this definition. However, people who have taken it for long may experience "caffeine withdrawal" symptoms like headache, anxiety, fatigue, drowsiness or depression, 12–24 hours after the last dose of caffeine but resolves within 24–48 hours. 

Q. Is caffeine good for heart?
Caffeine is a central nervous system stimulant, and is used in combination with pain-relieving medication to ease headache, migraine pain, neuralgia, toothache, sore throat and period pains. Increased doses may have side effects like increased heart rate (tachycardia), abnormal heart beats (cardiac arrhythmias). Always consult your doctor for the recommended indications, doses and side effects, if any.


Q. Is mesalazine a steroid, NSAID, immunosuppressant, blood-thinner or sulfa drug?
Mesalazine is not a steroid, NSAID, immunosuppressant, blood-thinner or sulfa drug. It is an anti-inflammatory drug.

Q. Can I take mesalazine forever?
No. Mesalazine should only be taken for the duration prescribed by your doctor.

Q. Is mesalazine safe?
Yes. Mesalazine is relatively safe if used as recommended. In case of any side-effects, consult your doctor.

Q. Can I take Asacol with Advil, Nyquil, tylenol, aspirin, Gaviscon, Imodium?
Asacol (mesalazine) can be taken with Nyquil, Tylenol (paracetamol), Gaviscon (sodium alginate) and Imodium (loperamide) only if prescribed by your doctor. It should not be taken with Advil (ibuprofen) or aspirin.

Q. Does mesalazine cause bleeding, weight gain, hair loss, immune suppression or liver problems?
Mesalazine may cause liver problems, immune suppression, hair loss, or bleeding. If you experience any such symptoms, please consult your doctor.

Q. Does mesalazine affect fertility or sperm count?
There is no evidence of mesalazine affecting fertility, but it may very rarely and reversibly reduce sperm count. If you experience any such problems, please consult your doctor.

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