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MDS (Oral Pathology & Microbiology), BDS
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MD (Pharmacology), MBBS
Last updated on:
16 Jul 2019 | 04:52 PM (IST)
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Plazole 20 mg Capsule

Prescription Required

Overview

Plazole Capsule side effects

Common
  • Headache
  • Stomach pain
  • Nausea
  • Flatulence
  • Diarrhea

How to use Plazole Capsule

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Plazole 20 mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Plazole Capsule works

Plazole 20 mg Capsule is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Plazole Capsule related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Plazole 20 mg Capsule.
Pregnancy
WEIGH RISKS VS BENEFITS
Plazole 20 mg Capsule may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
CAUTION
Plazole 20 mg Capsule is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Driving
Do not drive unless you are feeling well.
Plazole 20 mg Capsule may cause dizziness and visual disturbances. This may affect your driving ability.
Kidney
SAFE
Plazole 20 mg Capsule is safe to use in patients with kidney disease. No dose adjustment of Plazole 20 mg Capsule is recommended.
Liver
Plazole 20 mg Capsule should be used with caution in patients with severe liver disease. Dose adjustment of Plazole 20 mg Capsule may be needed. Please consult your doctor.
A lower dose may be advised in patients with liver disease and who have to take this medicine for a long time.

What if you miss a dose of Plazole Capsule?

If you miss a dose of Plazole 20 mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Plazole 20 mg Capsule
₹3.9/Capsule
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Eldeom 20mg Capsule
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₹1/Capsule
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Omesec 20 Capsule
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Omee Capsule
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Expert Advice

  • Take it one hour before meal, preferably in the morning.
  • It is a well-tolerated medicine and provides relief for a long time.
  • Some healthy tips to prevent acidity from happening:
    • Avoid taking hot tea, coffee, spicy food, and chocolate. Instead, have cold milk and cold coffee as these help neutralize the acid in the stomach.
    • Avoid alcohol and smoking.
    • Avoid eating late at night or before bedtime.
       
  • Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
  • Long-term use can cause weak bones and deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
  • Do not stop taking medication without talking to your doctor. 

Interaction with Drugs

Taking Plazole with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Konit
SERIOUS
Brand(s): Dizapam
SERIOUS
Brand(s): Risure
SERIOUS
Brand(s): Psycopan, Anxionil
SERIOUS
Brand(s): Eurolam, Alwel, Tenzo
SERIOUS
Brand(s): Panik
SERIOUS
Brand(s): Stoin
MODERATE
Brand(s): Methosis
MODERATE
Brand(s): Zuroxy, Roxilim, Rox Thro
MINOR
Brand(s): Clopinorm
MINOR

Patient Concerns

Questions Related to Plazole

arrow
Suffering from acid reflux disease due to which pain in throat and right side of lower abdomen
Dr. Saurav Arora
Homeopathy
Dear sir for the time being you can take Robinia 30, 04 drops in half cup water and Nixocid tab 2 tab thrice daily for a month, but as this case needs supervision, discussion and examination you need to visit a homeopath so that he can discuss your case in detail, get some investigations, do examination and guide you accordingly,
I grind my teeth in sleep. What should i do?
Dr. Jyoti Kapoor Madan
Psychiatrist
Grinding your teeth or bruxism is a sleep related movement disorder.Doctors don't completely understand what causes bruxism. Possible physical or psychological causes may include: Emotions, such as anxiety, stress, anger, frustration or tension Aggressive, competitive or hyperactive personality type Abnormal alignment of upper and lower teeth (malocclusion) Other sleep problems, such as sleep apnea Response to pain from an earache or teething (in children) Stomach acid reflux into the esophagus An uncommon side effect of some psychiatric medications, such as phenothiazines or certain antidepressants A coping strategy or focusing habit Complication resulting from a disorder such as Huntington's disease or Parkinson's diseaseIn case it is causing damage to your teeth , visit a dentist.In case you have headache, facial pain, get a psychiatric evaluation
arrow
Do you have any questions related to Plazole 20 mg Capsule?

FAQs

Q. Can I take Plazole with domperidone?

Plazole can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Plazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Q. What are the various conditions in which the use of Plazole is contraindicated?

Use of Plazole is contraindicated if you are allergic to this medicine or any other medicine belonging to the same class of drugs. Also, do not take Plazole if you are already taking a medicine containing nelfinavir (used for the treatment of HIV infection).

Q. What if I miss my dose of Plazole?

If you miss a dose of Plazole, take it as soon as you remember and the next dose as scheduled. However, if it is almost the time for your next dose, skip the missed dose and take your next dose and then follow the regular schedule. Do not take double the dose.

Q. Can I take Plazole along with oral contraceptive pills (birth control pills)?

Plazole can be safely taken with oral contraceptive pills (birth control). They do not affect each other's action and no harmful effects have been seen when they are used together.

Q. What is Plazole?

Plazole belongs to the group of medicines known as proton pump inhibitors (PPIs). This drug decreases the acid production in your stomach and is indicated for the treatment of conditions caused by excess acid secretion in the stomach.

Q. Can Plazole cause subacute cutaneous lupus erythematosus?

Plazole has been reported to cause subacute cutaneous lupus erythematosus in many studies. Common signs and symptoms of this disease include painful joints, tiredness, weakness, rash, fever, anemia, mouth ulcers, hair loss, and many others and these may get aggravated again and again. Talk to your doctor if you experience these side effects as you may need to discontinue this medicine.

Q. Can I take Plazole with ondansetron?

Ondansetron is an anti-emetic medicine which helps in relieving nausea (feeling sick) or vomiting. No harmful effects have been seen when Plazole is used with ondansetron. So, these two medicines can be taken together.

Q. Can Plazole cause lactose intolerance?

Lactose intolerance has been reported with the use of Plazole in some patients. Many Plazole preparations contain lactose as an ingredient. This is a digestive problem in which the patient cannot digest lactose, a type of sugar mainly found in milk and dairy products. The patient may complain of symptoms like flatulence (gas), diarrhea, bloating, stomach pain and feeling of being sick (nausea). Read the ingredients mentioned on the pack before taking the medicine.

Q. Can I take Plazole with Vitamin E?

Plazole can be taken with vitamin E. The combinations seems to have a beneficial effect in terms of better maintenance of moderate to severe esophagitis. However, there are not many studies or reports on this subject. Talk to your doctor for more information on this.

Q. Can I take Plazole with levosulpiride?

Plazole can be safely taken with levosulpiride as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Levosulpiride works by increasing the gut motility and Plazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Q. Does Plazole use increase the risk of clostridium difficile infection?

Use of proton pump inhibitors (PPIs) like Plazole may be associated with an increased risk of Clostridium difficile–associated diarrhea (CDAD) as reported in few studies and informed by the US FDA as well. A possibility of CDAD can be there in patients taking PPIs and developed diarrhea that does not improve.

Q. Can Plazole be used in cancer patients?

Plazole can be taken by cancer patients as prescribed by a doctor. Since cancer patients may also take many other medicines for the primary cancer treatment or for other symptoms and infections, there are chances of drug interactions with Plazole.

Q. For how long can Plazole be taken?

Take Plazole for as long as advised by your doctor. The duration of taking Plazole would vary depending on your condition. Do not stop taking this medicine without talking to your doctor.

Q. Can Plazole cause calcium deficiency and osteoporosis?

Plazole can cause osteoporosis (thinning of bones) as it decreases the calcium absorption leading to calcium deficiency. This leads to an increased risk of bone fractures on long-term use, like hip, wrist or spine fractures. Inform your doctor if you have osteoporosis or if you are taking corticosteroids (these can increase the risk of osteoporosis) before starting your therapy. Take enough calcium and vitamin D to reduce the risk.

Q. What are the rare side effects of Plazole?

Rare side effects seen with the use of Plazole includes a decrease in white cells or platelets, allergic reactions, problems like blurred vision, wheezing, shortness of breath (bronchospasm), dry mouth, thrush, liver problems like jaundice, hair loss (alopecia), skin rash on exposure to sunshine, joint pains (arthralgia) or muscle pains (myalgia), severe kidney problems (interstitial nephritis), increased sweating and inflammation of the gut causing diarrhoea.

Q. How does Plazole work?

Proton (acid) pumps are found on the stomach mucosa and they are responsible for secreting acid in the stomach. Plazole works by blocking this gastric acid pump and this unique mechanism of action helps in decreasing the acid secretion in the stomach.

Q. Does Plazole cause hepatitis B and can a patient of hepatitis take Plazole?

Plazole can rarely cause hepatitis with or without jaundice and very rarely it can lead to hepatic failure and encephalopathy in patients with the underlying liver disease. Plazole does not cause hepatitis B or any other viral hepatitis. However, there are studies showing an increased occurrence of hepatic encephalopathy in hepatitis B patients using PPIs. These medicines should be used with caution in patients with the underlying liver disease.

Q. Does Plazole increase chromogranin levels?

Use of proton pump inhibitors like Plazole has been seen to be associated with an increase in chromogranin levels. This increase in chromogranin levels can be due to the effect of these drugs on enterochromaffin cells and this could also falsely increase the levels in patients with neuroendocrine tumours.

Q. Does Plazole cause dementia?

Use of proton pump inhibitors like Plazole has been recently linked with the development of dementia in elderly patients. As this risk of developing dementia is not confirmed, talk to your doctor for more information on this effect.

Q. Does Plazole cause vitamin deficiencies?

Plazole may cause vitamin B12 and vitamin C deficiency. When taken orally, vitamin B12 requires an acidic environment for its absorption from the stomach while Plazole causes a decrease the gastric acid secretion. You may need to take vitamin B12 supplements from outside. The clinical significance of the decrease in vitamin C levels is not known, so vitamin C supplementation is not recommended.

Q. Does Plazole have an expiry date?

Yes, Plazole does expire. Please check the expiry date written on the pack and it refers to the last day of that month. Do not use Plazole after the expiry date.

Q. What is the role of Plazole before endoscopy in patients with gastrointestinal bleeding?

Plazole before endoscopy in patients with gastrointestinal bleeding reduces the need for endoscopic therapy, the rate of post-endoscopy bleeding, and shortens hospital stays. Hence Plazole is given before endoscopy in patients with gastrointestinal bleeding.

Q. Are there any withdrawal symptoms associated with the use of Plazole?

There are no withdrawal symptoms seen when patients stop using Plazole as it has no habit forming tendencies.

Q. Can Plazole cause magnesium deficiency?

Plazole can cause magnesium deficiency in the blood. Low magnesium levels is a rare side effect seen in patients treated with Plazole for at least three months and in most cases after a year of therapy. The patient may have symptoms like tetany, arrhythmias, and seizures and may need to stop this medicine and take magnesium from outside. Magnesium levels should be tested at regular intervals in the patients taking Plazole for a long duration.

Q. Is Plazole a controlled substance?

Plazole is not a controlled substance. It is available when prescribed by a doctor.

Q. Can Plazole be used in cardiac patients?

Patients with cardiac disease can take Plazole. However, Plazole can interact with certain drugs (e.g clopidogrel, digoxin) which might be used by a patient with an underlying cardiac disease. Patients taking Plazole and digoxin may need to be monitored for digoxin toxicity. Plazole decreases the activation of clopidogrel, thus reducing its effects. Patients taking these medicines together needs to be monitored closely by a doctor.

Q. Can the use of Plazole cause iron deficiency?

Use of Plazole can cause iron deficiency and a decrease in hemoglobin levels as it decreases the acidic environment of the stomach needed for the absorption of iron. However, there are no recommendations on the regular monitoring of iron levels or taking iron supplements when the patient is taking Plazole.

Q. Is Plazole a narcotic substance?

Plazole is a not a narcotic substance and has not been reported to have any abuse potential. Plazole does not get you high and does not cause any addiction as no withdrawal symptoms have been reported when you stop taking this drug.

Q. Is Plazole available without a prescription as an over the counter product?

Plazole is a prescription medicine and you can buy this drug by providing a doctor's prescription. Plazole is not available as an over the counter (OTC) product.

Q. How is Plazole metabolised in the body?

Plazole is metabolized in the liver by the cytochrome P450 enzymes mainly CYP2C19. There could be an increase in the level of Plazole in patients with underlying liver disease because of a decrease in its metabolism. However, the amount of drug does not increase if given once a day.

Q. Can Plazole be used in stroke patients?

Plazole can be used in stroke patients. There are studies suggesting that proton-pump inhibitors (PPIs) as a class are not associated with an increased short-term risk of recurrent stroke or death among older adults treated with clopidogrel after stroke.

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References
  1. Wallace JL, Sharkey KA. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 24 Jan. 2019] (online) Available from:External Link
  2. Omeprazole. Nottingham, NG: The Boots Company PLC; 2017. [Accessed on 28 Mar. 2019] (online) Available from:External Link
  3. Omeprazole. Wilmington, Delaware: AstraZeneca LP; 1989. [Accessed 28 Mar. 2019] (online) Available from:External Link
  4. U.S. National Library of Medicine. Omeprazole. [Accessed 28 Mar. 2019] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Malad West, Mumbai, Maharashtra
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